PMID- 34435331
OWN - NLM
STAT- MEDLINE
DCOM- 20220324
LR  - 20220324
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 58
IP  - 11
DP  - 2021 Nov
TI  - Neuropsychiatric Manifestations of Wilson Disease: Correlation with MRI and 
      Glutamate Excitotoxicity.
PG  - 6020-6031
LID - 10.1007/s12035-021-02525-4 [doi]
AB  - This study aims to identify neuropsychiatric manifestations in neurological 
      Wilson disease (NWD), and their correlation with MRI changes and glutamate 
      excitotoxicity. Forty-three consecutive patients with NWD from a tertiary care 
      teaching hospital were evaluated prospectively who fulfilled the inclusion 
      criteria. The neuropsychiatric evaluation was done using Neuropsychiatric 
      Inventory (NPI) battery that assesses 12 domains including delusion, 
      hallucination, agitation/aggression, dysphoria/depression, anxiety, euphoria, 
      apathy, disinhibition, irritability, aberrant motor activity, appetite change, 
      and abnormal nighttime behavior. Cranial MRI was done using a 3 T machine, and 
      locations of signal changes were noted including the total number of MRI lesions. 
      Serum glutamate level was measured by a fluorescence microplate reader. Abnormal 
      NPI in various domains and total NPI scores were correlated with MRI lesions, 
      serum and urinary copper, and glutamate level. The median age of the patients was 
      16 years. Forty-one (48.8%) patients had cognitive impairment and 37 (86%) had 
      movement disorder. Neurobehavioral abnormality was detected in all-commonest 
      being agitation (90.7%) followed by appetite change (81.4%), elation (74.4%), 
      irritability (69.8%), anxiety (67.4%), depression (65.1%), apathy (44.2%), 
      night time abnormal behavior (32.6%), aberrant motor behavior (20.9%), delusions 
      (16.3%), and hallucination (18.6%). The thalamic lesion was associated with 
      depression, globus pallidus with depression and anxiety, caudate with anxiety and 
      agitation, brainstem with irritability, and frontal cortex with apathy. Serum 
      glutamate level was higher in NWD. NPI sum score correlated with MRI load and 
      glutamate level. Varying severity of neurobehavioral abnormalities are common in 
      the patients with NWD and correlate with the location of MRI lesion and glutamate 
      level.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Kalita, Jayantee
AU  - Kalita J
AUID- ORCID: 0000-0002-6141-3592
AD  - Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226014, India. jayanteek@yahoo.com.
FAU - Kumar, Vijay
AU  - Kumar V
AUID- ORCID: 0000-0002-8035-9181
AD  - Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, 
      Republic of Korea.
FAU - Parashar, Vasudev
AU  - Parashar V
AD  - Department of Neurology, Sawai Man Singh Medical College, Jaipur, 302004, India.
FAU - Misra, Usha K
AU  - Misra UK
AD  - Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226014, India.
LA  - eng
PT  - Journal Article
DEP - 20210826
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Neurotransmitter Agents)
RN  - 2S3PL1B6UJ (Quetiapine Fumarate)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Behavioral Symptoms/blood/diagnostic imaging/*etiology
MH  - Brain Mapping
MH  - Cognition Disorders/blood/diagnostic imaging/*etiology
MH  - Copper/blood/urine
MH  - Feeding and Eating Disorders/blood/etiology
MH  - Female
MH  - Glutamic Acid/*blood
MH  - Hallucinations/diagnostic imaging/drug therapy/etiology
MH  - Hepatolenticular Degeneration/*complications/diagnostic imaging/metabolism
MH  - Humans
MH  - Liver/diagnostic imaging
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Mood Disorders/blood/diagnostic imaging/etiology
MH  - Movement Disorders/blood/diagnostic imaging/*etiology
MH  - *Neuroimaging
MH  - Neurotransmitter Agents/metabolism
MH  - Quetiapine Fumarate/therapeutic use
MH  - Severity of Illness Index
MH  - Young Adult
OTO - NOTNLM
OT  - Anxiety
OT  - Delusion
OT  - Depression
OT  - Glutamate
OT  - Hallucination
OT  - Irritability
OT  - MRI
OT  - Wilson disease; Copper; Neuropsychiatric inventory
EDAT- 2021/08/27 06:00
MHDA- 2022/03/25 06:00
CRDT- 2021/08/26 06:24
PHST- 2021/03/18 00:00 [received]
PHST- 2021/08/05 00:00 [accepted]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2022/03/25 06:00 [medline]
PHST- 2021/08/26 06:24 [entrez]
AID - 10.1007/s12035-021-02525-4 [pii]
AID - 10.1007/s12035-021-02525-4 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2021 Nov;58(11):6020-6031. doi: 10.1007/s12035-021-02525-4. Epub 
      2021 Aug 26.