PMID- 34435583
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20231213
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 99
DP  - 2021 Oct
TI  - Ursolic acid inhibits FcepsilonRI-mediated mast cell activation and allergic 
      inflammation.
PG  - 107994
LID - S1567-5769(21)00630-5 [pii]
LID - 10.1016/j.intimp.2021.107994 [doi]
AB  - BACKGROUND: Mast cells are the primary cells that play a crucial role in the 
      allergic diseases via secretion of diverse allergic mediators. Ursolic acid (UA) 
      is a naturally occurring anti-inflammatory triterpenoid possessing various 
      biological properties such as immune regulation, antioxidant, and anti-fibrotic. 
      The aim of this study was to evaluate the effects of UA in FcepsilonRI-mediated mast 
      cell activation and allergic inflammation. METHODS: In this study, mast cells 
      were stimulated with immunoglobulin E (IgE) and the anti-allergic effects of UA 
      were assessed by measuring the levels of allergic mediators. In vivo effects of 
      UA were observed by generating passive cutaneous anaphylaxis (PCA) and active 
      systemic anaphylaxis (ASA) in mouse model. RESULTS: We found that UA inhibited 
      the degranulation of mast cell by suppressing the intracellular calcium level in 
      a concentration-dependent manner. UA inhibited the expression and the release of 
      pro-inflammatory cytokines in mast cells. Anti-allergic effects of UA were 
      demonstrated via suppression of FcepsilonRI-mediated signaling molecules. In addition, 
      UA inhibited the IgE-mediated PCA and ovalbumin-induced ASA reactions in a 
      dose-dependent manner. CONCLUSIONS: Based on these findings, we suggest that UA 
      might have potential as a therapeutic candidate for the treatment of allergic 
      inflammatory diseases via inhibition of FcepsilonRI-mediated mast cell activation.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Dhakal, Hima
AU  - Dhakal H
AD  - Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, 
      Kyungpook National University, Daegu, Republic of Korea.
FAU - Kim, Min-Jong
AU  - Kim MJ
AD  - Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, 
      Kyungpook National University, Daegu, Republic of Korea.
FAU - Lee, Soyoung
AU  - Lee S
AD  - Immunoregulatory Materials Research Center, Korea Research Institute of 
      Bioscience and Biotechnology, Jeongeup, Republic of Korea.
FAU - Choi, Young-Ae
AU  - Choi YA
AD  - Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, 
      Kyungpook National University, Daegu, Republic of Korea.
FAU - Kim, Namkyung
AU  - Kim N
AD  - Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, 
      Kyungpook National University, Daegu, Republic of Korea.
FAU - Kwon, Taeg Kyu
AU  - Kwon TK
AD  - Department of Immunology, School of Medicine, Keimyung University, Daegu, 
      Republic of Korea.
FAU - Khang, Dongwoo
AU  - Khang D
AD  - Department of Physiology, School of Medicine, Gachon University, Incheon, 
      Republic of Korea. Electronic address: dkhang@gachon.ac.kr.
FAU - Kim, Sang-Hyun
AU  - Kim SH
AD  - Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, 
      Kyungpook National University, Daegu, Republic of Korea. Electronic address: 
      shkim72@knu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20210813
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Triterpenes)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Anaphylaxis/chemically induced/drug therapy
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Calcium/metabolism
MH  - Cell Degranulation/*drug effects
MH  - Cytokines/metabolism
MH  - Inflammation/drug therapy/*metabolism
MH  - Male
MH  - Mast Cell Activation Disorders
MH  - Mast Cells/drug effects/*metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects
MH  - Triterpenes/*pharmacology
MH  - Ursolic Acid
OTO - NOTNLM
OT  - Allergic inflammation
OT  - Histamine
OT  - Mast cell
OT  - Ursolic acid
EDAT- 2021/08/27 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/08/26 08:58
PHST- 2021/05/20 00:00 [received]
PHST- 2021/07/14 00:00 [revised]
PHST- 2021/07/14 00:00 [accepted]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/08/26 08:58 [entrez]
AID - S1567-5769(21)00630-5 [pii]
AID - 10.1016/j.intimp.2021.107994 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2021 Oct;99:107994. doi: 10.1016/j.intimp.2021.107994. Epub 
      2021 Aug 13.