PMID- 34436209
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210831
IS  - 2309-608X (Electronic)
IS  - 2309-608X (Linking)
VI  - 7
IP  - 8
DP  - 2021 Aug 19
TI  - Cunninghamella arunalokei a New Species of Cunninghamella from India Causing 
      Disease in an Immunocompetent Individual.
LID - 10.3390/jof7080670 [doi]
LID - 670
AB  - Mucormycosis due to Cunninghamella spp. is a rare disease, especially in 
      immunocompetent individuals. Here, we describe the isolation and characterization 
      of a new species of Cunninghamella, causing chronic rhino-orbital-cerebral 
      disease, and review cases of mucormycosis due to Cunninghamella spp. in 
      immunocompetent individuals. The Basic Local Alignment Search Tool (BLAST) 
      analysis of the internal transcribed spacer region (ITS) sequence of isolate 
      NCCPF 890012 showed 90% similarity with Cunninghamella bigelovii, while the large 
      ribosomal subunit (28S) and translation elongation factor-1 alpha (EF-1 alpha) 
      gene sequences showed 98% identity. Further, the phylogenetic analysis with 
      concatenated sequences clustered isolate (NCCPF 890012) closely with C. 
      bigelovii. The ITS sequence showed the maximum variation among three genes 
      analyzed and helped in the new species' delineation. Comparison of the assembled 
      whole genome of NCCPF 890012 with other Mucorales using 123 single-copy 
      orthologous genes showed clustering within the genus Cunninghamella. Based on 
      these findings, the isolate is considered to be a new species of Cunninghamella 
      and designated as Cunninghamella arunalokei sp. nov. Despite repeated debridement 
      and antifungal treatment, the patient had multiple recurrences with intracranial 
      extension and succumbed to the illness.
FAU - Hallur, Vinaykumar
AU  - Hallur V
AUID- ORCID: 0000-0002-1001-7717
AD  - Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar 
      751019, India.
FAU - Prakash, Hariprasath
AU  - Prakash H
AD  - Medical Microbiology, Department of Public Health, International Higher School of 
      Medicine, Issyk-Kul Regional Campus, Cholpon-Ata 722125, Kyrgyzstan.
FAU - Sable, Mukund
AU  - Sable M
AD  - Department of Pathology and Laboratory Medicine, All India Institute of Medical 
      Sciences, Bhubaneswar 751019, India.
FAU - Preetam, Chappity
AU  - Preetam C
AD  - ENT and Head and Neck Surgery, All India Institute of Medical Sciences, 
      Bhubaneswar 751019, India.
FAU - Purushotham, Prashanth
AU  - Purushotham P
AUID- ORCID: 0000-0001-6615-7973
AD  - Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar 
      751019, India.
FAU - Senapati, Rabindra
AU  - Senapati R
AD  - Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar 
      751019, India.
FAU - Shankarnarayan, Shamanth Adekhandi
AU  - Shankarnarayan SA
AD  - Department of Medical Microbiology, Postgraduate Institute of Medical Education 
      and Research, Chandigarh 160012, India.
FAU - Bag, Nerbadyswari Deep
AU  - Bag ND
AD  - Department of Radiodiagnosis, All India Institute of Medical Sciences, 
      Bhubaneswar 751019, India.
FAU - Rudramurthy, Shivaprakash Mandya
AU  - Rudramurthy SM
AUID- ORCID: 0000-0002-9097-9253
AD  - Department of Medical Microbiology, Postgraduate Institute of Medical Education 
      and Research, Chandigarh 160012, India.
LA  - eng
PT  - Journal Article
DEP - 20210819
PL  - Switzerland
TA  - J Fungi (Basel)
JT  - Journal of fungi (Basel, Switzerland)
JID - 101671827
PMC - PMC8401845
OTO - NOTNLM
OT  - Cunninghamella
OT  - India
OT  - fungal infection
OT  - human
OT  - immunocompetent host
OT  - mucormycosis
OT  - new species
OT  - review
OT  - rhino-orbital-cerebral mucormycosis
OT  - taxonomy
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/08/27 06:00
MHDA- 2021/08/27 06:01
PMCR- 2021/08/19
CRDT- 2021/08/26 12:25
PHST- 2021/06/23 00:00 [received]
PHST- 2021/08/11 00:00 [revised]
PHST- 2021/08/12 00:00 [accepted]
PHST- 2021/08/26 12:25 [entrez]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2021/08/27 06:01 [medline]
PHST- 2021/08/19 00:00 [pmc-release]
AID - jof7080670 [pii]
AID - jof-07-00670 [pii]
AID - 10.3390/jof7080670 [doi]
PST - epublish
SO  - J Fungi (Basel). 2021 Aug 19;7(8):670. doi: 10.3390/jof7080670.