PMID- 34437604
OWN - NLM
STAT- MEDLINE
DCOM- 20211207
LR  - 20211214
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 8
DP  - 2021
TI  - Associations between relative grip strength and type 2 diabetes mellitus: The 
      Yangpyeong cohort of the Korean genome and epidemiology study.
PG  - e0256550
LID - 10.1371/journal.pone.0256550 [doi]
LID - e0256550
AB  - OBJECTIVE: To investigate the association between relative grip strength and the 
      prevalence of type 2 diabetes mellitus (T2DM) independently and in combination 
      with body mass index (BMI) in Korean adults. METHODS: The cross-sectional study 
      includes 2,811 men and women (age 40 to 92 years old) with no history of heart 
      disease, stroke, or cancer. Relative grip strength was measured by a handheld 
      dynamometer and calculated by dividing absolute grip strength by body weight. 
      Logistic regression analysis was used to calculate the odds ratios (ORs) and 95% 
      confidence intervals (CIs) of T2DM by sex-specific quintiles of relative grip 
      strength. In a joint analysis, participants were classified into 4 groups: "weak 
      (lowest 20% quintile one) and normal weight (BMI <25.0 kg/m2)", "weak and 
      overweight/obese (BMI >/=25.0 kg/m2)", "strong (upper 80% four quintiles) and 
      normal weight" or "strong and overweight/obese". RESULTS: Among the 2,811 
      participants, 371 were identified as having T2DM. Compared with the lowest 
      quintile of relative grip strength (weakest), the ORs (95% CIs) of T2DM were 0.73 
      (0.53-1.02), 0.68 (0.48-0.97), 0.72 (0.50-1.03), and 0.48 (0.32-0.74) in upper 
      quintiles two, three, four, and five, respectively, after adjusting for BMI and 
      other potential confounders. In the joint analysis, compared with the "weak and 
      overweight/obese" reference group, the odds of T2DM [ORs (95% CIs)] was lower in 
      the "strong and overweight/obese" group [0.65 (0.46-0.92)] and the "strong and 
      normal weight" group [0.49 (0.35-0.67)], after adjusting for potential 
      confounders. CONCLUSION: In this cross-sectional study, greater relative grip 
      strength was associated with a lower prevalence of T2DM independent of BMI in 
      Korean adults. Additional prospective studies are needed to determine whether a 
      causal association exists between relative grip strength and T2DM prevalence 
      considering BMI.
FAU - Kim, Geon Hui
AU  - Kim GH
AD  - Department of Physical Education, College of Education, Seoul National 
      University, Seoul, Republic of Korea.
FAU - Song, Bong Kil
AU  - Song BK
AUID- ORCID: 0000-0001-5913-110X
AD  - Department of Physical Education, College of Education, Seoul National 
      University, Seoul, Republic of Korea.
AD  - Department of Kinesiology, College of Human Sciences, Iowa State University, 
      Ames, Iowa, United States of America.
FAU - Kim, Jung Woon
AU  - Kim JW
AD  - Department of Physical Education, College of Education, Seoul National 
      University, Seoul, Republic of Korea.
FAU - Lefferts, Elizabeth C
AU  - Lefferts EC
AD  - Department of Kinesiology, College of Human Sciences, Iowa State University, 
      Ames, Iowa, United States of America.
FAU - Brellenthin, Angelique G
AU  - Brellenthin AG
AD  - Department of Kinesiology, College of Human Sciences, Iowa State University, 
      Ames, Iowa, United States of America.
FAU - Lee, Duck-Chul
AU  - Lee DC
AD  - Department of Kinesiology, College of Human Sciences, Iowa State University, 
      Ames, Iowa, United States of America.
FAU - Kim, Yu-Mi
AU  - Kim YM
AD  - Department of Preventive Medicine, College of Medicine, Hanyang University, 
      Seoul, Republic of Korea.
AD  - Institute for Health and Society, Hanyang University, Seoul, Republic of Korea.
FAU - Kim, Mi Kyung
AU  - Kim MK
AD  - Department of Preventive Medicine, College of Medicine, Hanyang University, 
      Seoul, Republic of Korea.
AD  - Institute for Health and Society, Hanyang University, Seoul, Republic of Korea.
FAU - Choi, Bo Youl
AU  - Choi BY
AD  - Department of Preventive Medicine, College of Medicine, Hanyang University, 
      Seoul, Republic of Korea.
AD  - Institute for Health and Society, Hanyang University, Seoul, Republic of Korea.
FAU - Kim, Yeon Soo
AU  - Kim YS
AD  - Department of Physical Education, College of Education, Seoul National 
      University, Seoul, Republic of Korea.
AD  - Institute of Sports Science, Seoul National University, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210826
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/*physiopathology
MH  - Female
MH  - Hand Strength/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Republic of Korea/epidemiology
PMC - PMC8389482
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/08/27 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/08/26
CRDT- 2021/08/26 17:29
PHST- 2021/03/23 00:00 [received]
PHST- 2021/08/09 00:00 [accepted]
PHST- 2021/08/26 17:29 [entrez]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/08/26 00:00 [pmc-release]
AID - PONE-D-21-08378 [pii]
AID - 10.1371/journal.pone.0256550 [doi]
PST - epublish
SO  - PLoS One. 2021 Aug 26;16(8):e0256550. doi: 10.1371/journal.pone.0256550. 
      eCollection 2021.