PMID- 34437943
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220509
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 38
IP  - 4
DP  - 2022 Apr
TI  - Acellular Matrix-Induced Chondrogenesis Technique Improves the Results of 
      Chondral Lesions Associated With Femoroacetabular Impingement.
PG  - 1166-1178
LID - S0749-8063(21)00774-X [pii]
LID - 10.1016/j.arthro.2021.08.022 [doi]
AB  - PURPOSE: The study's main objective was to evaluate, in the short-term, the 
      result of the autologous acellular matrix-induced chondrogenesis (AMIC) technique 
      in a selected group of patients with 2-4 cm(2) full-thickness chondral lesions, 
      undergoing hip arthroscopy for femoroacetabular impingement (FAI). METHODS: A 
      retrospective single-center Level IV case series of 25 patients (28 hips) who 
      underwent an arthroscopic hip surgery with a liquid acellular collagen matrix. 
      Inclusion criteria for implantation were FAI diagnosis (cam or pincer type), 
      grade IV chondral lesions (Outerbridge size 2-4 cm(2)); Tonnis stage 0-II, 
      minimum follow-up of 24 months, and 1 year (12-15 months) evaluation with very 
      high field 3-T MRI arthrography. Exclusion criteria were Tonnis III, joint space 
      <2 mm, center-edge angle <20 degrees , and <24 months of follow-up. Clinical assessments 
      involved symptoms duration until surgery, changes in physical and work activity 
      and range of motion, modified Harris Hip Score, reporting percentages of patient 
      acceptable symptomatic state (PASS) and minimal clinically important difference 
      (MCID), pain with a VAS, and level of satisfaction. Radiological assessments: 
      Tonnis stage, articular space, alpha and lateral center edge angle (Wiberg), and 
      generated tissue characteristics at 1 year (based on the MOCART score), through 
      3-T MRI. RESULTS: 25 patients (28 hips) treated; 19 men and 6 women (mean age: 
      40.5 years; range: 25-55). Two women underwent joint replacement surgery. Thus, 
      23 patients (26 hips) were analyzed. At 29 months following surgery (range: 
      24-48), a significant improvement was obtained in all parameters assessed, 
      focusing on the characteristics of the generated tissue in the MRI (MOCART 
      scores). 95% of the patients met the MCID (improvement >12 points in the modified 
      Harris Hip Score), and 100% scored >74 points, achieving the PASS. Patients' 
      satisfaction was 86.6% (SD 16.4). All patients who practiced sports resumed them. 
      CONCLUSIONS: The liquid AMIC is a safe technique that shows good clinical and 
      radiological outcomes in a 2-year follow-up in patients with femoroacetabular 
      impingement and grade IV acetabular 2-4 cm(2) chondral defects. LEVEL OF 
      EVIDENCE: Level IV, retrospective case series.
CI  - Copyright (c) 2021 Arthroscopy Association of North America. Published by Elsevier 
      Inc. All rights reserved.
FAU - De Lucas Villarrubia, Jose Carlos
AU  - De Lucas Villarrubia JC
AD  - Traumatology and Orthopedic Surgery Department, Hospital Universitario Puerta de 
      Hierro, Majadahonda, Madrid, Spain. Electronic address: jclucasv@hotmail.com.
FAU - Mendez Alonso, Miguel Angel
AU  - Mendez Alonso MA
AD  - Department of Radiology, Hospital Universitario Puerta de Hierro, Majadahonda, 
      Madrid, Spain.
FAU - Sanz Perez, Marta Isabel
AU  - Sanz Perez MI
AD  - Traumatology and Orthopedic Surgery Department, Hospital Universitario Puerta de 
      Hierro, Majadahonda, Madrid, Spain.
FAU - Trell Lesmes, Fernando
AU  - Trell Lesmes F
AD  - Traumatology and Orthopedic Surgery Department, Hospital Universitario Puerta de 
      Hierro, Majadahonda, Madrid, Spain.
FAU - Panadero Tapia, Alberto
AU  - Panadero Tapia A
AD  - Department of Radiology, Hospital Universitario Puerta de Hierro, Majadahonda, 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20210824
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official 
      publication of the Arthroscopy Association of North America and the International 
      Arthroscopy Association
JID - 8506498
SB  - IM
MH  - Adult
MH  - Arthroscopy
MH  - Chondrogenesis
MH  - Female
MH  - *Femoracetabular Impingement/complications/diagnostic imaging/surgery
MH  - Hip Joint/surgery
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - MOCART
OT  - acellular collagen matrix
OT  - cartilage mapping
OT  - chondral lesion
OT  - femoroacetabular impingement
OT  - hip arthroscopy
OT  - magnetic resonance imaging
EDAT- 2021/08/27 06:00
MHDA- 2022/04/06 06:00
CRDT- 2021/08/26 20:14
PHST- 2021/03/25 00:00 [received]
PHST- 2021/08/11 00:00 [revised]
PHST- 2021/08/11 00:00 [accepted]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
PHST- 2021/08/26 20:14 [entrez]
AID - S0749-8063(21)00774-X [pii]
AID - 10.1016/j.arthro.2021.08.022 [doi]
PST - ppublish
SO  - Arthroscopy. 2022 Apr;38(4):1166-1178. doi: 10.1016/j.arthro.2021.08.022. Epub 
      2021 Aug 24.