PMID- 34438202 OWN - NLM STAT- MEDLINE DCOM- 20211102 LR - 20211102 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 143 DP - 2021 Nov TI - High neutrophil-lymphocyte ratio upon admission is associated with better response in psychotic depression. PG - 38-42 LID - S0022-3956(21)00520-3 [pii] LID - 10.1016/j.jpsychires.2021.08.021 [doi] AB - Recent evidence relates the inflammatory system to the aetiology and evolution of mood disorders. The Neutrophil-Lymphocyte Ratio (NLR) is an affordable and reproducible biomarker of inflammation. The aim of the study is to retrospectively evaluate the association between NLR and response to treatment in 50 patients aged over 50 with a diagnosis of Psychotic Depression (PD) who were admitted to an acute psychiatric unit between 2010 and 2018. They were stratified according to sex and treatment received: antidepressants, antipsychotics and electroconvulsive therapy (ECT). The NLR was collected on admission and the clinical response was quantified by the Global Assessment of Functioning (GAF) scale. In the simple linear regression, high NLR upon admission was associated with better clinical response during hospitalization as measured by GAF. When stratifying the patients, this association was maintained in women, in patients who received antidepressant treatment with tricyclics and SNRIs, antipsychotic treatment with olanzapine/quetiapine and those who did not receive ECT. NLR is an accessible biomarker in clinical practice, and in PD patients it could guide the therapeutic strategy and be a predictor of response. CI - Copyright (c) 2021 Elsevier Ltd. All rights reserved. FAU - Llorca-Bofi, Vicent AU - Llorca-Bofi V AD - Psychiatry Department, Hospital Universitari Santa Maria, Lleida, Spain. Electronic address: vicentllorcabofi@gmail.com. FAU - Palacios-Garran, Roberto AU - Palacios-Garran R AD - Psychiatry Department, Hospital Universitari Santa Maria, Lleida, Spain. Electronic address: rpalacios@gss.cat. FAU - Rey Routo, Diana AU - Rey Routo D AD - Psychiatry Department, Hospital Universitari Santa Maria, Lleida, Spain. Electronic address: drey@gss.cat. FAU - Buil-Reine, Esther AU - Buil-Reine E AD - Psychiatry Department, Hospital Universitari Santa Maria, Lleida, Spain. Electronic address: ebuil@gss.cat. FAU - Adrados-Perez, Marina AU - Adrados-Perez M AD - Psychiatry Department, Hospital Universitari Santa Maria, Lleida, Spain. Electronic address: madrados@gss.cat. FAU - Gich, Ignasi AU - Gich I AD - CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Clinical Epidemiology and Public Health, HSCSP, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain. Electronic address: igichs@santpau.cat. FAU - Bioque, Miquel AU - Bioque M AD - Barcelona Clinic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clinic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en red en salud Mental (CIBERSAM), Department of Medicine, University of Barcelona, Barcelona, Spain. Electronic address: mbioque@clinic.cat. FAU - Mur, Maria AU - Mur M AD - Psychiatry Department, Hospital Universitari Santa Maria, Lleida, Spain; Institut de Recerca Biomedica de Lleida (IRBLleida), Spain; Medicine Department. Universitat de Lleida (UdL), Spain. Electronic address: mmur@gss.cat. LA - eng PT - Journal Article DEP - 20210819 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Aged MH - *Depression MH - Female MH - Hospitalization MH - Humans MH - Lymphocytes MH - *Neutrophils MH - Retrospective Studies OTO - NOTNLM OT - Antidepressants OT - Antipsychotics OT - Electroconvulsive therapy OT - Neutrophil-lymphocyte ratio OT - Psychotic depression EDAT- 2021/08/27 06:00 MHDA- 2021/11/03 06:00 CRDT- 2021/08/26 20:20 PHST- 2021/03/21 00:00 [received] PHST- 2021/07/21 00:00 [revised] PHST- 2021/08/17 00:00 [accepted] PHST- 2021/08/27 06:00 [pubmed] PHST- 2021/11/03 06:00 [medline] PHST- 2021/08/26 20:20 [entrez] AID - S0022-3956(21)00520-3 [pii] AID - 10.1016/j.jpsychires.2021.08.021 [doi] PST - ppublish SO - J Psychiatr Res. 2021 Nov;143:38-42. doi: 10.1016/j.jpsychires.2021.08.021. Epub 2021 Aug 19.