PMID- 34438355
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20240405
IS  - 1096-0856 (Electronic)
IS  - 1090-7807 (Print)
IS  - 1090-7807 (Linking)
VI  - 331
DP  - 2021 Oct
TI  - Achieving high-resolution (1)H-MRSI of the human brain with compressed-sensing 
      and low-rank reconstruction at 7 Tesla.
PG  - 107048
LID - S1090-7807(21)00137-3 [pii]
LID - 10.1016/j.jmr.2021.107048 [doi]
AB  - Low sensitivity MR techniques such as magnetic resonance spectroscopic imaging 
      (MRSI) greatly benefit from the gain in signal-to-noise provided by ultra-high 
      field MR. High-resolution and whole-slab brain MRSI remains however very 
      challenging due to lengthy acquisition, low signal, lipid contamination and field 
      inhomogeneity. In this study, we propose an acquisition-reconstruction scheme 
      that combines (1)H free-induction-decay (FID)-MRSI sequence, short TR 
      acquisition, compressed sensing acceleration and low-rank modeling with 
      total-generalized-variation constraint to achieve metabolite imaging in two and 
      three dimensions at 7 Tesla. The resulting images and volumes reveal highly 
      detailed distributions that are specific to each metabolite and follow the 
      underlying brain anatomy. The MRSI method was validated in a high-resolution 
      phantom containing fine metabolite structures, and in five healthy volunteers. 
      This new application of compressed sensing acceleration paves the way for 
      high-resolution MRSI in clinical setting with acquisition times of 5 min for 2D 
      MRSI at 2.5 mm and of 20 min for 3D MRSI at 3.3 mm isotropic.
CI  - Copyright (c) 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Klauser, Antoine
AU  - Klauser A
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 
      Massachusetts General Hospital, Harvard Medical School, Boston, MA, United 
      States; Department of Radiology and Medical Informatics, University of Geneva, 
      Switzerland; Center for Biomedical Imaging (CIBM), Geneva, Switzerland. 
      Electronic address: antoine.klauser@unige.ch.
FAU - Strasser, Bernhard
AU  - Strasser B
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 
      Massachusetts General Hospital, Harvard Medical School, Boston, MA, United 
      States.
FAU - Thapa, Bijaya
AU  - Thapa B
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 
      Massachusetts General Hospital, Harvard Medical School, Boston, MA, United 
      States.
FAU - Lazeyras, Francois
AU  - Lazeyras F
AD  - Department of Radiology and Medical Informatics, University of Geneva, 
      Switzerland; Center for Biomedical Imaging (CIBM), Geneva, Switzerland.
FAU - Andronesi, Ovidiu
AU  - Andronesi O
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 
      Massachusetts General Hospital, Harvard Medical School, Boston, MA, United 
      States.
LA  - eng
GR  - J 4124/FWF_/Austrian Science Fund FWF/Austria
GR  - R01 CA211080/CA/NCI NIH HHS/United States
GR  - R01 CA255479/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210811
PL  - United States
TA  - J Magn Reson
JT  - Journal of magnetic resonance (San Diego, Calif. : 1997)
JID - 9707935
SB  - IM
MH  - *Brain/diagnostic imaging
MH  - Head
MH  - Healthy Volunteers
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Phantoms, Imaging
PMC - PMC8717865
MID - NIHMS1764738
OTO - NOTNLM
OT  - Acceleration
OT  - Brain metabolite
OT  - Compressed-sensing
OT  - Magnetic resonance spectroscopic imaging
OT  - SENSE
OT  - Spectroscopy
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/08/27 06:00
MHDA- 2022/01/18 06:00
PMCR- 2022/10/01
CRDT- 2021/08/26 20:30
PHST- 2021/02/05 00:00 [received]
PHST- 2021/06/29 00:00 [revised]
PHST- 2021/08/08 00:00 [accepted]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2021/08/26 20:30 [entrez]
PHST- 2022/10/01 00:00 [pmc-release]
AID - S1090-7807(21)00137-3 [pii]
AID - 10.1016/j.jmr.2021.107048 [doi]
PST - ppublish
SO  - J Magn Reson. 2021 Oct;331:107048. doi: 10.1016/j.jmr.2021.107048. Epub 2021 Aug 
      11.