PMID- 34438518
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230920
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 8
IP  - 8
DP  - 2021 Jul 23
TI  - Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study.
LID - 10.3390/children8080627 [doi]
LID - 627
AB  - Type 2 Diabetes Mellitus (T2DM) is a main cause of chronic kidney disease (CKD) 
      in adulthood. No studies have examined the occurrence of acute kidney injury 
      (AKI)-that enhances the risk of later CKD-and renal tubular damage (RTD)-that can 
      evolve to AKI-in children with onset of T2DM. We aimed to evaluate the prevalence 
      and possible features of AKI and RTD in a prospectively enrolled population of 
      children with onset of T2DM. We consecutively enrolled 10 children aged 12.9 +/- 
      2.3 years with newly diagnosed T2DM. AKI was defined according to the KDIGO 
      criteria. RTD was defined by abnormal urinary beta-2-microglobulin and/or tubular 
      reabsorption of phosphate (TRP) <85% and/or fractional excretion of Na >2%. None 
      of the patients developed AKI, whereas 3/10 developed RTD with high 
      beta-2-microglobulin levels (range: 0.6-1.06 mg/L). One of these three patients 
      also presented with reduced TRP levels (TRP = 70%). Proteinuria was observed in 
      two out of three patients with RTD, while none of patients without RTD had 
      proteinuria. Patients with RTD presented higher beta-2-microglobulin, acute 
      creatinine/estimated basal creatinine ratio, and serum ketones levels compared 
      with patients without RTD. In conclusion, in our pilot observation, we found that 
      none of the 10 children with T2DM onset developed AKI, whereas three of them 
      developed RTD.
FAU - Marzuillo, Pierluigi
AU  - Marzuillo P
AUID- ORCID: 0000-0003-4682-0170
AD  - Department of Woman, Child and of General and Specialized Surgery, Universita 
      degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 801138 
      Naples, Italy.
FAU - Di Sessa, Anna
AU  - Di Sessa A
AUID- ORCID: 0000-0002-5877-3757
AD  - Department of Woman, Child and of General and Specialized Surgery, Universita 
      degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 801138 
      Naples, Italy.
FAU - Palma, Pier Luigi
AU  - Palma PL
AD  - Department of Woman, Child and of General and Specialized Surgery, Universita 
      degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 801138 
      Naples, Italy.
FAU - Umano, Giuseppina Rosaria
AU  - Umano GR
AUID- ORCID: 0000-0002-5570-6620
AD  - Department of Woman, Child and of General and Specialized Surgery, Universita 
      degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 801138 
      Naples, Italy.
FAU - Polito, Cesare
AU  - Polito C
AD  - Department of Woman, Child and of General and Specialized Surgery, Universita 
      degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 801138 
      Naples, Italy.
FAU - Iafusco, Dario
AU  - Iafusco D
AD  - Department of Woman, Child and of General and Specialized Surgery, Universita 
      degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 801138 
      Naples, Italy.
FAU - Guarino, Stefano
AU  - Guarino S
AD  - Department of Woman, Child and of General and Specialized Surgery, Universita 
      degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 801138 
      Naples, Italy.
FAU - Miraglia Del Giudice, Emanuele
AU  - Miraglia Del Giudice E
AD  - Department of Woman, Child and of General and Specialized Surgery, Universita 
      degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 801138 
      Naples, Italy.
LA  - eng
GR  - 204328/20/Department of Woman, Child and of General and Specialized Surgery/
PT  - Journal Article
DEP - 20210723
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC8392677
OTO - NOTNLM
OT  - acute kidney injury
OT  - children
OT  - renal tubular damage
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/07/23
CRDT- 2021/08/27 01:01
PHST- 2021/05/16 00:00 [received]
PHST- 2021/07/22 00:00 [revised]
PHST- 2021/07/23 00:00 [accepted]
PHST- 2021/08/27 01:01 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/07/23 00:00 [pmc-release]
AID - children8080627 [pii]
AID - children-08-00627 [pii]
AID - 10.3390/children8080627 [doi]
PST - epublish
SO  - Children (Basel). 2021 Jul 23;8(8):627. doi: 10.3390/children8080627.