PMID- 34439254
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210830
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 13
IP  - 16
DP  - 2021 Aug 14
TI  - First Comparison between [18f]-FMISO and [18f]-Faza for Preoperative Pet Imaging 
      of Hypoxia in Lung Cancer.
LID - 10.3390/cancers13164101 [doi]
LID - 4101
AB  - Hypoxic areas are typically resistant to treatment. However, the 
      fluorine-18-fluoroazomycin-arabinoside (FAZA) and fluorine 18 misonidazole 
      (FMISO) tracers have never been compared in non small cell lung cancer (NSCLC). 
      This study compares the capability of 18F-FAZA PET/CT with that of 18F-FMISO 
      PET/CT for detecting hypoxic tumour regions in early and locally advanced NSCLC 
      patients. We prospectively evaluated patients who underwent preoperative PET 
      scans before surgery for localised NSCLC (i.e., fluorodeoxyglucose (FDG)-PET, 
      FMISO-PET, and FAZA-PET). The PET data of the three tracers were compared with 
      each other and then compared to immunohistochemical analysis (GLUT-1, CAIX, 
      LDH-5, and HIF1-Alpha) after tumour resection. Overall, 19 patients with a mean 
      age of 68.2 +/- 8 years were included. There were 18 lesions with significant 
      uptake (i.e., SUVmax >1.4) for the F-MISO and 17 for FAZA. The mean SUVmax was 3 
      (+/-1.4) with a mean volume of 25.8 cc (+/-25.8) for FMISO and 2.2 (+/-0.7) with a mean 
      volume of 13.06 cc (+/-13.76) for FAZA. The SUVmax of F-MISO was greater than that 
      of FAZA (p = 0.0003). The SUVmax of F-MISO shows a good correlation with that of 
      FAZA at 0.86 (0.66-0.94). Immunohistochemical results are not correlated to 
      hypoxia PET regardless of the staining. The two tracers show a good correlation 
      with hypoxia, with FMISO being superior to FAZA. FMISO, therefore, remains the 
      reference tracer for defining hypoxic volumes.
FAU - Thureau, Sebastien
AU  - Thureau S
AUID- ORCID: 0000-0001-5772-2336
AD  - Department of Radiation Oncology, Henri Becquerel Cancer Center and Rouen 
      University Hospital, & QuantIF-LITIS [EA (Equipe d'Accueil) 4108], 76000 Rouen, 
      France.
AD  - Department of Nuclear Medicine, Henri Becquerel Cancer Center and Rouen 
      University Hospital, & QuantIF-LITIS [EA (Equipe d'Accueil) 4108-FR CNRS 3638], 
      Faculty of Medicine, University of Rouen, 76000 Rouen, France.
FAU - Piton, Nicolas
AU  - Piton N
AUID- ORCID: 0000-0001-8779-586X
AD  - Department of Pathology, France and Normandie University, UNIROUEN, Inserm U1245, 
      Rouen University Hospital, 76000 Rouen, France.
FAU - Gouel, Pierrick
AU  - Gouel P
AD  - Department of Nuclear Medicine, Henri Becquerel Cancer Center and Rouen 
      University Hospital, & QuantIF-LITIS [EA (Equipe d'Accueil) 4108-FR CNRS 3638], 
      Faculty of Medicine, University of Rouen, 76000 Rouen, France.
FAU - Modzelewski, Romain
AU  - Modzelewski R
AD  - Department of Nuclear Medicine, Henri Becquerel Cancer Center and Rouen 
      University Hospital, & QuantIF-LITIS [EA (Equipe d'Accueil) 4108-FR CNRS 3638], 
      Faculty of Medicine, University of Rouen, 76000 Rouen, France.
FAU - Dujon, Antoine
AU  - Dujon A
AD  - Clinic of Cedre, 76000 Rouen, France.
FAU - Baste, Jean-Marc
AU  - Baste JM
AD  - Unit of General and Thoracic Surgery, Rouen University Hospital, 76000 Rouen, 
      France.
FAU - Melki, Jean
AU  - Melki J
AD  - Unit of General and Thoracic Surgery, Rouen University Hospital, 76000 Rouen, 
      France.
FAU - Rinieri, Philippe
AU  - Rinieri P
AD  - Unit of General and Thoracic Surgery, Rouen University Hospital, 76000 Rouen, 
      France.
FAU - Peillon, Christophe
AU  - Peillon C
AD  - Unit of General and Thoracic Surgery, Rouen University Hospital, 76000 Rouen, 
      France.
FAU - Rastelli, Olivier
AU  - Rastelli O
AD  - Unit of Clinic Research, Henri Becquerel Cancer Center, 76000 Rouen, France.
FAU - Lequesne, Justine
AU  - Lequesne J
AD  - Unit of Clinic Research, Henri Becquerel Cancer Center, 76000 Rouen, France.
FAU - Hapdey, Sebastien
AU  - Hapdey S
AUID- ORCID: 0000-0002-3967-434X
AD  - Department of Nuclear Medicine, Henri Becquerel Cancer Center and Rouen 
      University Hospital, & QuantIF-LITIS [EA (Equipe d'Accueil) 4108-FR CNRS 3638], 
      Faculty of Medicine, University of Rouen, 76000 Rouen, France.
FAU - Sabourin, Jean-Christophe
AU  - Sabourin JC
AD  - Department of Pathology, France and Normandie University, UNIROUEN, Inserm U1245, 
      Rouen University Hospital, 76000 Rouen, France.
FAU - Bohn, Pierre
AU  - Bohn P
AUID- ORCID: 0000-0001-8972-9022
AD  - Department of Nuclear Medicine, Henri Becquerel Cancer Center and Rouen 
      University Hospital, & QuantIF-LITIS [EA (Equipe d'Accueil) 4108-FR CNRS 3638], 
      Faculty of Medicine, University of Rouen, 76000 Rouen, France.
FAU - Vera, Pierre
AU  - Vera P
AD  - Department of Nuclear Medicine, Henri Becquerel Cancer Center and Rouen 
      University Hospital, & QuantIF-LITIS [EA (Equipe d'Accueil) 4108-FR CNRS 3638], 
      Faculty of Medicine, University of Rouen, 76000 Rouen, France.
LA  - eng
PT  - Journal Article
DEP - 20210814
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8392878
OTO - NOTNLM
OT  - FAZA
OT  - FMISO
OT  - PET
OT  - hypoxia
OT  - lung cancer
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/08/14
CRDT- 2021/08/27 01:03
PHST- 2021/05/25 00:00 [received]
PHST- 2021/08/01 00:00 [revised]
PHST- 2021/08/12 00:00 [accepted]
PHST- 2021/08/27 01:03 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/08/14 00:00 [pmc-release]
AID - cancers13164101 [pii]
AID - cancers-13-04101 [pii]
AID - 10.3390/cancers13164101 [doi]
PST - epublish
SO  - Cancers (Basel). 2021 Aug 14;13(16):4101. doi: 10.3390/cancers13164101.