PMID- 34440545
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210831
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 11
IP  - 8
DP  - 2021 Aug 9
TI  - Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review.
LID - 10.3390/life11080801 [doi]
LID - 801
AB  - Antiphospholipid syndrome (APS) is an autoimmune disease characterized by 
      autoreactive B and T cells against beta2-glycoprotein I (B2GPI), with vascular 
      thrombosis or obstetrical complications. Dendritic cells (DCs) are crucial in the 
      generation of autoimmunity. Here, we conducted a comprehensive systematic review 
      on the relationship between DC and APS. We performed a literature search of 
      PubMed as of 26 March 2021. A total of 33 articles were extracted. DCs are 
      pivotal in inducing inflammatory responses and orchestrating adaptive immunity. 
      DCs contribute to the local inflammation regarding vascular thrombosis or 
      obstetrical complications. Both B2GPI and antiphospholipid antibodies (aPL) can 
      promote antigen presentation by DCs and the generation or maintenance of 
      autoimmunity. In addition, plasmacytoid DC activation is enhanced by aPL, thereby 
      augmenting the inflammatory response. In line with these findings, DC modulation 
      appears promising as a future treatment for APS. In conclusion, our review 
      indicated the crucial role of DCs in the pathogenesis of APS. Deeper 
      understanding of the complex relationship would help in developing new treatment 
      strategies.
FAU - Tang, Kuo-Tung
AU  - Tang KT
AUID- ORCID: 0000-0002-5468-1329
AD  - Division of Allergy, Immunology and Rheumatology, Taichung Veterans General 
      Hospital, Taichung 40705, Taiwan.
AD  - Faculty of Medicine, National Yang-Ming Chiao Tung University, Taipei 11221, 
      Taiwan.
AD  - Ph.D. Program in Translational Medicine and Rong Hsing Research Center for 
      Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
FAU - Chen, Hsin-Hua
AU  - Chen HH
AUID- ORCID: 0000-0002-7304-4587
AD  - Division of Allergy, Immunology and Rheumatology, Taichung Veterans General 
      Hospital, Taichung 40705, Taiwan.
AD  - Faculty of Medicine, National Yang-Ming Chiao Tung University, Taipei 11221, 
      Taiwan.
AD  - Ph.D. Program in Translational Medicine and Rong Hsing Research Center for 
      Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung 
      40705, Taiwan.
AD  - Department of Industrial Engineering and Enterprise Information, Tunghai 
      University, Taichung 40704, Taiwan.
FAU - Chen, Tzu-Ting
AU  - Chen TT
AD  - Institute of Bioinformatics and Structural Biology and Department of Medical 
      Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
FAU - Bracci, Nicole R
AU  - Bracci NR
AUID- ORCID: 0000-0002-7298-4796
AD  - Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of 
      Veterinary Medicine, Virginia Polytechnic Institute and State University, 
      Blacksburg, VA 24061, USA.
FAU - Lin, Chi-Chien
AU  - Lin CC
AUID- ORCID: 0000-0002-1464-0231
AD  - Ph.D. Program in Translational Medicine and Rong Hsing Research Center for 
      Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung 
      40705, Taiwan.
AD  - Institute of Biomedical Science, The iEGG and Animal Biotechnology Center, 
      National Chung-Hsing University, Taichung 40227, Taiwan.
AD  - Department of Medical Research, China Medical University Hospital, Taichung 
      40447, Taiwan.
AD  - Department of Pharmacology, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung 80708, Taiwan.
LA  - eng
GR  - TCVGH-1073803B/Taichung Veterans General Hospital/
GR  - TCVGH-NCHU1077605, 1107604/National Chung-Hsing University/
PT  - Journal Article
PT  - Review
DEP - 20210809
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC8400181
OTO - NOTNLM
OT  - antiphospholipid syndrome
OT  - autoimmunity
OT  - dendritic cell
OT  - immune tolerance
OT  - beta2-glycoprotein I
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/08/09
CRDT- 2021/08/27 01:07
PHST- 2021/07/16 00:00 [received]
PHST- 2021/08/06 00:00 [revised]
PHST- 2021/08/07 00:00 [accepted]
PHST- 2021/08/27 01:07 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/08/09 00:00 [pmc-release]
AID - life11080801 [pii]
AID - life-11-00801 [pii]
AID - 10.3390/life11080801 [doi]
PST - epublish
SO  - Life (Basel). 2021 Aug 9;11(8):801. doi: 10.3390/life11080801.