PMID- 34440663
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 10
IP  - 8
DP  - 2021 Jul 26
TI  - Bone and Mineral Metabolism Phenotypes in MEN1-Related and Sporadic Primary 
      Hyperparathyroidism, before and after Parathyroidectomy.
LID - 10.3390/cells10081895 [doi]
LID - 1895
AB  - Primary hyperparathyroidism (PHPT) is the most common endocrinopathy in multiple 
      endocrine neoplasia type 1 (MEN1). Persistent levels of increased parathyroid 
      hormone (PTH) result in a higher incidence of osteopenia and osteoporosis 
      compared to the general population. Surgical removal of hyper-functioning 
      parathyroid tissue is the therapy of choice. This retrospective study evaluated 
      the effect of parathyroidectomy (PTX) on bone metabolism and bone mass in two 
      series of patients with MEN1 PHPT and sporadic PHPT (sPHPT) by comparing bone 
      metabolism-related biochemical markers and bone mineral density (BMD) before and 
      after surgery. Our data confirmed, in a higher number of cases than in previously 
      published studies, the efficacy of PTX, not only to rapidly restore normal levels 
      of PTH and calcium, but also to normalize biochemical parameters of bone 
      resorption and bone formation, and to improve spine and femur bone mass, in both 
      MEN1 PHPT and sPHPT. Evaluation of single-patient BMD changes after surgery 
      indicates an individual variable bone mass improvement in a great majority of 
      MEN1 PHPT patients. In MEN1 patients, PTX is strongly suggested in the presence 
      of increased PTH and hypercalcemia to prevent/reduce the early-onset bone mass 
      loss and grant, in young patients, the achievement of the bone mass peak; routine 
      monitoring of bone metabolism and bone mass should start from adolescence. 
      Therapy with anti-fracture drugs is indicated in MEN1 patients with BMD lower 
      than the age-matched normal values.
FAU - Marini, Francesca
AU  - Marini F
AUID- ORCID: 0000-0002-3678-4922
AD  - Department of Experimental and Clinical Biomedical Sciences, University of 
      Florence, 50139 Florence, Italy.
AD  - F.I.R.M.O. Italian Foundation for the Research on Bone Diseases, 50141 Florence, 
      Italy.
FAU - Giusti, Francesca
AU  - Giusti F
AUID- ORCID: 0000-0002-8576-9606
AD  - Department of Experimental and Clinical Biomedical Sciences, University of 
      Florence, 50139 Florence, Italy.
FAU - Cioppi, Federica
AU  - Cioppi F
AD  - SOD Bone and Mineral Metabolism Diseases, Azienda Ospedaliero Universitaria 
      Careggi (AOUC), 50139 Florence, Italy.
FAU - Maraghelli, Davide
AU  - Maraghelli D
AD  - Department of Experimental and Clinical Biomedical Sciences, University of 
      Florence, 50139 Florence, Italy.
FAU - Cavalli, Tiziana
AU  - Cavalli T
AD  - General, Mini-Invasive and Emergency Surgery Unit, Department of Surgery and 
      Orthopaedics, ASST "Carlo Poma", 46100 Mantua, Italy.
FAU - Tonelli, Francesco
AU  - Tonelli F
AD  - F.I.R.M.O. Italian Foundation for the Research on Bone Diseases, 50141 Florence, 
      Italy.
FAU - Brandi, Maria Luisa
AU  - Brandi ML
AUID- ORCID: 0000-0002-8741-0592
AD  - F.I.R.M.O. Italian Foundation for the Research on Bone Diseases, 50141 Florence, 
      Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20210726
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Biomarkers)
RN  - 0 (PTH protein, human)
RN  - 0 (Parathyroid Hormone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - *Bone Density
MH  - *Bone Remodeling
MH  - Bone and Bones/diagnostic imaging/*metabolism
MH  - Calcium/blood
MH  - Child
MH  - Databases, Factual
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism, Primary/diagnosis/etiology/metabolism/*surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications/diagnosis
MH  - Parathyroid Hormone/blood
MH  - *Parathyroidectomy
MH  - Phenotype
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC8391385
OTO - NOTNLM
OT  - bone mass
OT  - bone metabolism
OT  - multiple endocrine neoplasia type 1
OT  - parathyroidectomy
OT  - primary hyperparathyroidism
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/07/26
CRDT- 2021/08/27 01:07
PHST- 2021/06/10 00:00 [received]
PHST- 2021/07/12 00:00 [revised]
PHST- 2021/07/26 00:00 [accepted]
PHST- 2021/08/27 01:07 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/07/26 00:00 [pmc-release]
AID - cells10081895 [pii]
AID - cells-10-01895 [pii]
AID - 10.3390/cells10081895 [doi]
PST - epublish
SO  - Cells. 2021 Jul 26;10(8):1895. doi: 10.3390/cells10081895.