PMID- 34440939
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20211129
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 10
IP  - 8
DP  - 2021 Aug 23
TI  - Roles of IgE and Histamine in Mast Cell Maturation.
LID - 10.3390/cells10082170 [doi]
LID - 2170
AB  - Mast cells are activated upon immunoglobulin E (IgE)-mediated antigen 
      stimulation, and release a wide variety of mediators, including histamine to 
      trigger inflammatory responses. The surface expression levels of Fcepsilon receptor I 
      (FcepsilonRI), a high affinity receptor of IgE, were found to be positively regulated 
      by IgE. IgE could protect murine cultured mast cells from apoptotic cell death 
      induced by the deprivation of interleukin-3 and a certain kind of IgE could 
      activate immature mast cells in the absence of antigens, leading to the release 
      of pro-inflammatory cytokines and a transient increase in histamine synthesis. 
      Histamine synthesis in mast cells was found to be required for the maturation of 
      murine connective tissue-type mast cells, raising the possibility that IgE 
      indirectly modulates local mast cell maturation. Although it remains 
      controversial to what extent this concept of "monomeric IgE effects" could have 
      relevance in the modulation of human mast cell functions, the therapeutic effects 
      of anti-IgE antibodies might be accounted for in terms of the decreased serum IgE 
      concentrations. Because drastic increases in serum IgE concentrations are often 
      observed in patients with atopic dermatitis and chronic urticaria, a close 
      investigation of the roles of IgE in mast cell maturation should contribute to 
      development of novel therapeutic approaches for these inflammatory diseases.
FAU - Tanaka, Satoshi
AU  - Tanaka S
AUID- ORCID: 0000-0002-3468-7694
AD  - Department of Pharmacology, Division of Pathological Sciences, Kyoto 
      Pharmaceutical University, Misasagi Nakauchi-cho 5, Yamashina-ku, Kyoto 607-8414, 
      Japan.
FAU - Furuta, Kazuyuki
AU  - Furuta K
AD  - Department of Immunobiology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Tsushima naka 1-1-1, Kita-ku, Okayama 
      700-8530, Japan.
LA  - eng
GR  - 20K07040/Japan Society for the Promotion of Science/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210823
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (MRGPRX2 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Neuropeptide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Histamine/*metabolism
MH  - Humans
MH  - Hypersensitivity/metabolism
MH  - Immunoglobulin E/*metabolism
MH  - Inflammation/metabolism
MH  - Mast Cells/metabolism
MH  - Nerve Tissue Proteins/metabolism
MH  - Receptors, G-Protein-Coupled/metabolism
MH  - Receptors, Neuropeptide/metabolism
PMC - PMC8392195
OTO - NOTNLM
OT  - IgE
OT  - MRGPRX2
OT  - allergy
OT  - differentiation
OT  - histamine
OT  - inflammation
OT  - mast cell
OT  - omalizumab
OT  - urticaria
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/11/30 06:00
PMCR- 2021/08/23
CRDT- 2021/08/27 01:08
PHST- 2021/07/24 00:00 [received]
PHST- 2021/08/19 00:00 [revised]
PHST- 2021/08/20 00:00 [accepted]
PHST- 2021/08/27 01:08 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2021/08/23 00:00 [pmc-release]
AID - cells10082170 [pii]
AID - cells-10-02170 [pii]
AID - 10.3390/cells10082170 [doi]
PST - epublish
SO  - Cells. 2021 Aug 23;10(8):2170. doi: 10.3390/cells10082170.