PMID- 34441943
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210831
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 16
DP  - 2021 Aug 18
TI  - Factors Associated with Increased Neuroretinal Rim Thickness Measured Based on 
      Bruch's Membrane Opening-Minimum Rim Width after Trabeculectomy.
LID - 10.3390/jcm10163646 [doi]
LID - 3646
AB  - PURPOSE: To investigate the factors associated with an increase in the 
      neuroretinal rim (NRR) thickness measured based on Bruch's membrane 
      opening-minimum rim width (BMO-MRW) after trabeculectomy in patients with primary 
      open-angle glaucoma (POAG). METHODS: We analyzed the BMO-MRW using 
      spectral-domain optical coherence tomography (SD-OCT) of patients with POAG who 
      underwent a trabeculectomy for uncontrolled intraocular pressure (IOP) despite 
      maximal IOP reduction treatment. The BMO-MRW was measured before and after 
      trabeculectomy in patients with POAG. Demographic and systemic factors, ocular 
      factors, pre- and post-operative IOP, and visual field parameters were collected, 
      together with SD-OCT measurements. A regression analysis was performed to 
      investigate the factors that affected the change in the BMO-MRW after the 
      trabeculectomy. RESULTS: Forty-four eyes of 44 patients were included in the 
      analysis. The IOP significantly decreased from a preoperative 27.0 mmHg to a 
      postoperative 10.5 mmHg. The mean interval between the trabeculectomy and the 
      date of post-operative SD-OCT measurement was 3.3 months. The global and sectoral 
      BMO-MRW significantly increased after trabeculectomy, whereas the peripapillary 
      retinal nerve fiber layer thickness did not show a difference between before and 
      after the trabeculectomy. Younger age and a greater reduction in the IOP after 
      the trabeculectomy were significantly associated with the increase in the BMO-MRW 
      after trabeculectomy. CONCLUSIONS: The NRR thickness measured based on the 
      BMO-MRW increased with decreasing IOP after trabeculectomy, and the increase in 
      the BMO-MRW was associated with the young age of the patients and greater 
      reduction in the IOP after trabeculectomy. Biomechanically, these suggest that 
      the NRR comprises cells and substances that sensitively respond to changes in the 
      IOP and age.
FAU - Park, Do-Young
AU  - Park DY
AD  - Department of Ophthalmology, Yeungnam University Hospital, Yeungnam University 
      College of Medicine, Daegu 42415, Korea.
FAU - Cha, Soon-Cheol
AU  - Cha SC
AD  - Department of Ophthalmology, Yeungnam University Hospital, Yeungnam University 
      College of Medicine, Daegu 42415, Korea.
LA  - eng
GR  - 2019R1F1A1062796/Basic Science Research Program, National Research Foundation of 
      Korea/
GR  - 2019M3E5D1A02068088/Basic Science Research Program, National Research Foundation 
      of Korea/
PT  - Journal Article
DEP - 20210818
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8397154
OTO - NOTNLM
OT  - Bruch's membrane opening-minimum rim width
OT  - intraocular pressure
OT  - neuroretinal rim reversal
OT  - trabeculectomy
COIS- All authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/08/18
CRDT- 2021/08/27 01:11
PHST- 2021/07/07 00:00 [received]
PHST- 2021/08/12 00:00 [revised]
PHST- 2021/08/16 00:00 [accepted]
PHST- 2021/08/27 01:11 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/08/18 00:00 [pmc-release]
AID - jcm10163646 [pii]
AID - jcm-10-03646 [pii]
AID - 10.3390/jcm10163646 [doi]
PST - epublish
SO  - J Clin Med. 2021 Aug 18;10(16):3646. doi: 10.3390/jcm10163646.