PMID- 34441962
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210830
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 16
DP  - 2021 Aug 19
TI  - Complete Atrioventricular Septal Defects after the Age of 40 Years.
LID - 10.3390/jcm10163665 [doi]
LID - 3665
AB  - BACKGROUND: There is an increasing number of adults with complete 
      atrioventricular septal defects (cAVSD). However, data regarding older adults are 
      lacking. The aim of this study is to analyze the outcome of adults with cAVSD 
      over the age of 40 years. METHODS: Patients with cAVSD who were >/=40 years of age 
      at any point between 2005 until 2018 were included retrospectively. Data were 
      retrieved from hospital records. The primary endpoint was a combination of death 
      from any cause and unplanned hospitalizations due to cardiac reasons. RESULTS: 43 
      patients (60.5% female, mean age 43.7 +/- 6.0 years, genetic syndrome 58.1%) were 
      included. At begin of follow-up, the majority of patients (n = 41, 95.3%) was in 
      New York Heart Association (NYHA) class I or II. Out of the whole cohort 26 
      (60.5%) had undergone cardiac surgery. At baseline, at least one extracardiac 
      comorbidity was present in 40 patients (93.0%). Median follow-up was 1.7 years 
      (IQR 0.3-4.6). On univariate Cox analysis, NYHA class at begin of follow-up 
      (hazard ratio: 1.96, CI 95%: 1.04-3.72, p < 0.05) was the only predictor for the 
      primary endpoint. CONCLUSIONS: Significant morbidity and mortality is present in 
      cAVSD patients over the age of 40 years. NYHA class is predictive for a worse 
      outcome.
FAU - Maurer, Susanne J
AU  - Maurer SJ
AD  - Department of Electrophysiology, German Heart Centre Munich, TUM School of 
      Medicine, Technical University of Munich, 80636 Munich, Germany.
FAU - Moosholzer, Lorena
AU  - Moosholzer L
AD  - Department of Congenital Heart Disease and Paediatric Cardiology, German Heart 
      Centre Munich, TUM School of Medicine, Technical University of Munich, 80636 
      Munich, Germany.
FAU - Pujol, Claudia
AU  - Pujol C
AD  - Department of Congenital Heart Disease and Paediatric Cardiology, German Heart 
      Centre Munich, TUM School of Medicine, Technical University of Munich, 80636 
      Munich, Germany.
FAU - Nagdyman, Nicole
AU  - Nagdyman N
AD  - Department of Congenital Heart Disease and Paediatric Cardiology, German Heart 
      Centre Munich, TUM School of Medicine, Technical University of Munich, 80636 
      Munich, Germany.
FAU - Ewert, Peter
AU  - Ewert P
AD  - Department of Congenital Heart Disease and Paediatric Cardiology, German Heart 
      Centre Munich, TUM School of Medicine, Technical University of Munich, 80636 
      Munich, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart 
      Alliance, 80992 Munich, Germany.
FAU - Tutarel, Oktay
AU  - Tutarel O
AUID- ORCID: 0000-0002-5201-5509
AD  - Department of Congenital Heart Disease and Paediatric Cardiology, German Heart 
      Centre Munich, TUM School of Medicine, Technical University of Munich, 80636 
      Munich, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart 
      Alliance, 80992 Munich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210819
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8396930
OTO - NOTNLM
OT  - adult congenital heart disease
OT  - atrioventricular septal defects
OT  - mortality
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/08/19
CRDT- 2021/08/27 01:11
PHST- 2021/06/01 00:00 [received]
PHST- 2021/07/27 00:00 [revised]
PHST- 2021/08/18 00:00 [accepted]
PHST- 2021/08/27 01:11 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/08/19 00:00 [pmc-release]
AID - jcm10163665 [pii]
AID - jcm-10-03665 [pii]
AID - 10.3390/jcm10163665 [doi]
PST - epublish
SO  - J Clin Med. 2021 Aug 19;10(16):3665. doi: 10.3390/jcm10163665.