PMID- 34442348
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210831
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 11
IP  - 8
DP  - 2021 Jul 23
TI  - Matrix Metalloproteinase-3 (MMP-3) Polymorphisms Are Associated with Prolonged 
      ECG-Derived QTc Interval: A Cross-Sectional Study of the Australian Rural 
      Population.
LID - 10.3390/jpm11080705 [doi]
LID - 705
AB  - Matrix metalloproteinases (MMPs) are enzymes that are integral in extracellular 
      matrix (ECM) remodeling. In age or disease, ECM may become dysregulated and 
      contribute to fibrosis, which impairs cardiac electrical conduction. Two alleles 
      regulate matrix metalloproteinase-3 (MMP-3) activity: one with five adenosine 
      bases (5A; associated with higher MMP-3 activity and decreased fibrosis) and 
      another with six adenosine bases (6A; associated with lower MMP-3 activity and 
      increased fibrosis). Here, we determined whether ECG-derived QTc and related 
      parameters are associated with the MMP-3 5A/6A genotype in a cross-section of the 
      Australian rural population. A retrospective cross-sectional population was 
      obtained from the Charles Sturt University Diabetes Screening Research 
      Initiative. Genotype and resting 12-lead ECG parameters of 295 participants were 
      analyzed. Amongst these participants, 85 individuals carried the 5A/5A genotype, 
      141 individuals carried the 5A/6A genotype, and 65 individuals carried the 6A/6A 
      genotype. Compared to 5A/5A genotype carriers, 5A/6A genotype carriers had a 
      significantly longer QTc duration by 9.50 ms (95% CI: 3.48-15.52, p = 0.002), 
      whilst 6A/6A genotype carriers had an even longer QTc duration by 12.19 ms (95% 
      CI: 5.04-19.34, p = 0.001). We found an association between MMP-3 5A/6A 
      polymorphisms and QTc, independent of adjustments for age, gender, alcohol 
      consumption, smoking status, body mass index and blood pressure.
FAU - Lu, Yaxin
AU  - Lu Y
AD  - JL Operating Theatres, Royal Prince Alfred Hospital, Camperdown 2050, Australia.
FAU - Ussher, Nathan
AU  - Ussher N
AD  - Rural Clinical School, University of New South Wales, Sydney 2052, Australia.
FAU - Zhou, Yuling
AU  - Zhou Y
AD  - Xiamen Cardiovascular Hospital, Xiamen University, Xiamen 361005, China.
AD  - The School of Economics, Xiamen University, Xiamen 361005, China.
FAU - Jelinek, Herbert
AU  - Jelinek H
AD  - Health Sciences, Charles Sturt University, Albury 2640, Australia.
FAU - Hambly, Brett
AU  - Hambly B
AD  - Department of Pathology, University of Sydney, Sydney 2006, Australia.
AD  - Center for Healthy Futures, Torrens University, Pyrmont 2009, Australia.
FAU - Li, Amy
AU  - Li A
AUID- ORCID: 0000-0001-5413-3771
AD  - Center for Healthy Futures, Torrens University, Pyrmont 2009, Australia.
AD  - Department of Pharmacy & Biomedical Sciences, La Trobe University, Flora Hill 
      3552, Australia.
FAU - McLachlan, Craig S
AU  - McLachlan CS
AD  - Center for Healthy Futures, Torrens University, Pyrmont 2009, Australia.
LA  - eng
PT  - Journal Article
DEP - 20210723
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC8399546
OTO - NOTNLM
OT  - ECG
OT  - MMP-3
OT  - matrix metalloproteinases
OT  - rural populations
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/07/23
CRDT- 2021/08/27 01:12
PHST- 2021/06/29 00:00 [received]
PHST- 2021/07/20 00:00 [accepted]
PHST- 2021/08/27 01:12 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/07/23 00:00 [pmc-release]
AID - jpm11080705 [pii]
AID - jpm-11-00705 [pii]
AID - 10.3390/jpm11080705 [doi]
PST - epublish
SO  - J Pers Med. 2021 Jul 23;11(8):705. doi: 10.3390/jpm11080705.