PMID- 34442356
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210831
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 11
IP  - 8
DP  - 2021 Jul 25
TI  - Vitamin D Levels in Asymptomatic Children and Adolescents with Atopy during the 
      COVID-19 Era.
LID - 10.3390/jpm11080712 [doi]
LID - 712
AB  - This study assessed vitamin D status in asymptomatic children and adolescents in 
      Greece, with and without atopy, and possible changes during the coronavirus 
      disease 2019 (COVID-19) pandemic. Serum levels of 25-hydroxy-vitamin D (25(OH)D) 
      and total immunoglobulin E (IgE), and eosinophil count were measured in 340 
      asymptomatic children and adolescents (155 males, 185 females), mean age 8.6 +/- 
      4.6 years, recruited over a period of 24 months (February 2019-January 2021). 
      Atopy, defined by high level of IgE for age, was associated with vitamin D 
      deficient status (p = 0.041). Subjects with and without atopy showed similar 
      rates of insufficient and normal levels of 25(OH)D. The median level of 25(OH)D 
      was significantly higher in subjects recruited during the pandemic, when home 
      confinement rules were observed, than before the pandemic, and significantly more 
      children had normal levels of 25(OH)D (p < 0.001), but no differences were 
      noticed for IgE levels or eosinophil count. These results support a link between 
      vitamin D and allergic and infectious inflammations, and specifically the 
      association of vitamin D deficiency with asymptomatic atopy, defined as increased 
      IgE level for age.
FAU - Feketea, Gavriela
AU  - Feketea G
AUID- ORCID: 0000-0001-9026-2597
AD  - Department of Haematology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 
      400337 Cluj-Napoca, Romania.
AD  - Hospital Unit of Amaliada, Department of Paediatrics, 27200 Amaliada, Greece.
FAU - Vlacha, Vasiliki
AU  - Vlacha V
AUID- ORCID: 0000-0003-1845-6025
AD  - Department of Paediatrics, Karamandanio Children's Hospital, 26331 Patras, 
      Greece.
AD  - Department of Early Years Learning and Care, University of Ioannina, 26331 
      Ioannina, Greece.
FAU - Tsiros, Georgios
AU  - Tsiros G
AD  - Gastouni Health Centre, Department of Family Medicine, 27300 Gastouni, Greece.
FAU - Voila, Panagiota
AU  - Voila P
AD  - Private Medical Laboratory, Clinical Chemistry Department, 27200 Amaliada, 
      Greece.
FAU - Pop, Raluca Maria
AU  - Pop RM
AUID- ORCID: 0000-0003-1899-5977
AD  - Department of Pharmacology, Toxicology and Clinical Pharmacology, "Iuliu 
      Hatieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
FAU - Bocsan, Ioana Corina
AU  - Bocsan IC
AUID- ORCID: 0000-0002-3279-5384
AD  - Department of Pharmacology, Toxicology and Clinical Pharmacology, "Iuliu 
      Hatieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
FAU - Stanciu, Luminita Aurelia
AU  - Stanciu LA
AUID- ORCID: 0000-0001-6811-6972
AD  - National Heart and Lung Institute, Imperial College London, London W2 1PG, UK.
FAU - Zdrenghea, Mihnea
AU  - Zdrenghea M
AUID- ORCID: 0000-0002-9461-987X
AD  - Department of Haematology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 
      400337 Cluj-Napoca, Romania.
AD  - Ion Chiricuta Oncology Institute, Republicii Str., No. 34-36, 400010 Cluj-Napoca, 
      Romania.
LA  - eng
PT  - Journal Article
DEP - 20210725
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC8400733
OTO - NOTNLM
OT  - COVID-19
OT  - atopy
OT  - vitamin D
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/07/25
CRDT- 2021/08/27 01:12
PHST- 2021/06/10 00:00 [received]
PHST- 2021/07/20 00:00 [revised]
PHST- 2021/07/23 00:00 [accepted]
PHST- 2021/08/27 01:12 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/07/25 00:00 [pmc-release]
AID - jpm11080712 [pii]
AID - jpm-11-00712 [pii]
AID - 10.3390/jpm11080712 [doi]
PST - epublish
SO  - J Pers Med. 2021 Jul 25;11(8):712. doi: 10.3390/jpm11080712.