PMID- 34444736
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20231107
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 8
DP  - 2021 Jul 27
TI  - Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by 
      Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats.
LID - 10.3390/nu13082577 [doi]
LID - 2577
AB  - Pomegranate juice (Punica granatum) has been used since ancient times in 
      traditional medicine (Unani Medicine, Ayurveda); its main compounds are 
      anthocyanins and ellagic acid, which have anti-inflammatory, antioxidant, 
      hepatoprotective, and cardiovascular health effects. The objective was to 
      evaluate the effect of pomegranate juice on inflammation, blood pressure, and 
      vascular and physiological markers associated with obesity induced by a high-fat 
      diet in a murine model. The results show that pomegranate juice reduces the 
      concentration of low-density lipoprotein cholesterol (cLDL) 39% and increases the 
      concentration of high-density lipoprotein cholesterol (cHDL) by 27%, leading to a 
      12%-18% decrease in the risk of cardiovascular diseases (CVD). In addition to 
      reducing blood pressure by 24%, it also had an antiatherogenic effect by 
      decreasing sE-selectin levels by 42%. On the other hand, the juice significantly 
      increased adiponectin levels in adipose tissue, decreased levels of inflammation 
      markers (tumor necrosis factor-alpha (TNF-alpha), plasminogen activator inhibitor-1 
      (PAI-1), interleukin-17A (IL-17A), interleukin-6 (IL-6), interleukin-1beta (IL-1beta)), 
      and inhibited the monocyte chemoattractant protein-1 (MCP-1). Pomegranate juice 
      requires clinical studies to prove its immunoregulatory and therapeutic effects 
      on cardiovascular and atherogenic risks.
FAU - Michicotl-Meneses, Maria Monica
AU  - Michicotl-Meneses MM
AUID- ORCID: 0000-0002-9842-5562
AD  - Departamento de Ingenieria Bioquimica, Instituto Politecnico Nacional, Escuela 
      Nacional de Ciencias Biologicas, Mexico City 07738, Mexico.
FAU - Thompson-Bonilla, Maria Del Rocio
AU  - Thompson-Bonilla MDR
AD  - Laboratorio de Medicina Genomica, Investigacion Biomedica y Traslacional, ISSSTE, 
      Hospital Regional "1 degrees  de Octubre", Mexico City 07760, Mexico.
FAU - Reyes-Lopez, Cesar A
AU  - Reyes-Lopez CA
AUID- ORCID: 0000-0002-9860-8983
AD  - Laboratorio de Bioquimica Estructural, Instituto Politecnico Nacional, Escuela 
      Nacional de Medicina y Homeopatia, Mexico City 07320, Mexico.
FAU - Garcia-Perez, Blanca Estela
AU  - Garcia-Perez BE
AUID- ORCID: 0000-0001-6610-5559
AD  - Laboratorio de Microbiologia General, Instituto Politecnico Nacional, Escuela 
      Nacional de Ciencias Biologicas, Mexico City 11340, Mexico.
FAU - Lopez-Tenorio, Itzel I
AU  - Lopez-Tenorio II
AD  - Departamento de Ingenieria Bioquimica, Instituto Politecnico Nacional, Escuela 
      Nacional de Ciencias Biologicas, Mexico City 07738, Mexico.
FAU - Ordaz-Pichardo, Cynthia
AU  - Ordaz-Pichardo C
AUID- ORCID: 0000-0002-0938-3365
AD  - Laboratorio de Biologia Celular y Productos Naturales, Instituto Politecnico 
      Nacional, Escuela Nacional de Medicina y Homeopatia, Mexico City 07320, Mexico.
FAU - Jaramillo-Flores, Maria Eugenia
AU  - Jaramillo-Flores ME
AD  - Departamento de Ingenieria Bioquimica, Instituto Politecnico Nacional, Escuela 
      Nacional de Ciencias Biologicas, Mexico City 07738, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20210727
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Lipids)
SB  - IM
MH  - Adiponectin/metabolism
MH  - Adipose Tissue/immunology/*metabolism
MH  - Animals
MH  - Biomarkers/analysis
MH  - Blood Pressure
MH  - Cardiovascular Diseases/etiology/*prevention & control
MH  - Chemokine CCL2/antagonists & inhibitors
MH  - Cytokines/metabolism
MH  - Diet, High-Fat
MH  - Energy Intake
MH  - *Fruit and Vegetable Juices/analysis
MH  - *Heart Disease Risk Factors
MH  - *Inflammation
MH  - Lipids/blood
MH  - Male
MH  - Obesity/complications/*physiopathology
MH  - *Pomegranate
MH  - Rats
MH  - Rats, Wistar
PMC - PMC8402035
OTO - NOTNLM
OT  - anthocyanins
OT  - atherosclerosis vascular risk
OT  - high-fat diet
OT  - inflammation
OT  - obesity
OT  - pomegranate juice
OT  - pro-inflammatory cytokines
OT  - selectin
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/09/18 06:00
PMCR- 2021/07/27
CRDT- 2021/08/27 01:21
PHST- 2021/07/07 00:00 [received]
PHST- 2021/07/22 00:00 [revised]
PHST- 2021/07/25 00:00 [accepted]
PHST- 2021/08/27 01:21 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2021/07/27 00:00 [pmc-release]
AID - nu13082577 [pii]
AID - nutrients-13-02577 [pii]
AID - 10.3390/nu13082577 [doi]
PST - epublish
SO  - Nutrients. 2021 Jul 27;13(8):2577. doi: 10.3390/nu13082577.