PMID- 34444842
OWN - NLM
STAT- MEDLINE
DCOM- 20210915
LR  - 20210915
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 8
DP  - 2021 Aug 2
TI  - A Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program 
      Is Associated with Increased Leukocyte Telomere Length in Children and 
      Adolescents with Overweight and Obesity.
LID - 10.3390/nu13082682 [doi]
LID - 2682
AB  - Leucocyte telomere length (LTL) is a robust marker of biological aging and is 
      associated with obesity and cardiometabolic risk factors in childhood and 
      adolescence. We investigated the effect of a structured, comprehensive, 
      multidisciplinary, personalized, lifestyle intervention program of healthy diet 
      and physical exercise on LTL in 508 children and adolescents (239 males, 269 
      females; 282 prepubertal, 226 pubertal), aged 10.14 +/- 0.13 years. Participants 
      were classified as obese (n = 267, 52.6%), overweight (n = 174, 34.2%), or of 
      normal BMI (n = 67, 13.2%) according to the International Obesity Task Force 
      (IOTF) cutoff points and were studied prospectively for one year. We demonstrated 
      that LTL increased significantly after 1 year of the lifestyle interventions, 
      irrespective of gender, pubertal status, or body mass index (BMI). Waist 
      circumference was the best negative predictor of LTL at initial assessment. The 
      implementation of the lifestyle interventions also resulted in a significant 
      improvement in clinical (BMI, BMI z-score and waist to height ratio) and body 
      composition indices of obesity, inflammatory markers, hepatic enzymes, glycated 
      hemoglobin (HbA1C), quantitative insulin sensitivity check index (QUICKI), and 
      lipid profile in all participants. These findings indicate that the increased LTL 
      may be associated with a more favorable metabolic profile and decreased morbidity 
      later in life.
FAU - Paltoglou, George
AU  - Paltoglou G
AUID- ORCID: 0000-0003-4300-7061
AD  - Division of Endocrinology, Metabolism and Diabetes, First Department of 
      Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia 
      Sophia' Children's Hospital, 11527 Athens, Greece.
FAU - Raftopoulou, Christina
AU  - Raftopoulou C
AD  - Division of Endocrinology and Metabolism, Center for Clinical, Experimental 
      Surgery and Translational Research, Biomedical Research Foundation of the Academy 
      of Athens, 11527 Athens, Greece.
FAU - Nicolaides, Nicolas C
AU  - Nicolaides NC
AD  - Division of Endocrinology, Metabolism and Diabetes, First Department of 
      Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia 
      Sophia' Children's Hospital, 11527 Athens, Greece.
FAU - Genitsaridi, Sofia M
AU  - Genitsaridi SM
AD  - Division of Endocrinology, Metabolism and Diabetes, First Department of 
      Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia 
      Sophia' Children's Hospital, 11527 Athens, Greece.
FAU - Karampatsou, Sofia I
AU  - Karampatsou SI
AD  - Division of Endocrinology, Metabolism and Diabetes, First Department of 
      Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia 
      Sophia' Children's Hospital, 11527 Athens, Greece.
FAU - Papadopoulou, Marina
AU  - Papadopoulou M
AD  - Division of Endocrinology, Metabolism and Diabetes, First Department of 
      Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia 
      Sophia' Children's Hospital, 11527 Athens, Greece.
FAU - Kassari, Penio
AU  - Kassari P
AUID- ORCID: 0000-0003-2464-1825
AD  - Division of Endocrinology, Metabolism and Diabetes, First Department of 
      Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia 
      Sophia' Children's Hospital, 11527 Athens, Greece.
FAU - Charmandari, Evangelia
AU  - Charmandari E
AUID- ORCID: 0000-0002-0851-6998
AD  - Division of Endocrinology, Metabolism and Diabetes, First Department of 
      Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia 
      Sophia' Children's Hospital, 11527 Athens, Greece.
AD  - Division of Endocrinology and Metabolism, Center for Clinical, Experimental 
      Surgery and Translational Research, Biomedical Research Foundation of the Academy 
      of Athens, 11527 Athens, Greece.
LA  - eng
GR  - (project code: T1EDK-01386, MIS: 5030543, Acronym: PEDOBESITY)./This research has 
      been co-financed by the European Regional Development Fund of the European Union 
      and Greek national funds through the Operational Program Competitiveness, 
      Entrepreneurship and Innovation, under the call RESEARCH - CREATE - INNOVATE/
PT  - Clinical Trial
PT  - Journal Article
DEP - 20210802
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Adolescent
MH  - Aging/*genetics
MH  - Behavior Therapy/methods
MH  - Body Composition
MH  - Body Mass Index
MH  - Child
MH  - Exercise/physiology
MH  - Female
MH  - Humans
MH  - Leukocytes/*pathology
MH  - Life Style
MH  - Male
MH  - Pediatric Obesity/blood/*genetics/therapy
MH  - Program Evaluation
MH  - Prospective Studies
MH  - Telomere/*pathology
MH  - Treatment Outcome
MH  - Waist Circumference
MH  - Weight Reduction Programs/*methods
PMC - PMC8402072
OTO - NOTNLM
OT  - adolescence
OT  - childhood
OT  - leukocyte telomere length
OT  - obesity
OT  - overweight
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/09/16 06:00
PMCR- 2021/08/02
CRDT- 2021/08/27 01:21
PHST- 2021/06/15 00:00 [received]
PHST- 2021/07/19 00:00 [revised]
PHST- 2021/07/21 00:00 [accepted]
PHST- 2021/08/27 01:21 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/09/16 06:00 [medline]
PHST- 2021/08/02 00:00 [pmc-release]
AID - nu13082682 [pii]
AID - nutrients-13-02682 [pii]
AID - 10.3390/nu13082682 [doi]
PST - epublish
SO  - Nutrients. 2021 Aug 2;13(8):2682. doi: 10.3390/nu13082682.