PMID- 34444964
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20231107
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 8
DP  - 2021 Aug 16
TI  - Metabolic Derangement in Pediatric Patient with Obesity: The Role of Ketogenic 
      Diet as Therapeutic Tool.
LID - 10.3390/nu13082805 [doi]
LID - 2805
AB  - Obesity is defined as a condition characterized by an excessive fat accumulation 
      that has negative health consequences. Pediatric obesity is associated with an 
      increased risk for many diseases, including impaired glycemic and lipidic control 
      that may lead to the development of chronic, and potentially disabling, 
      pathologies, such as type 2 diabetes mellitus (T2DM) and cardiovascular events, 
      in adult life. The therapeutic strategy initially starts with interventions that 
      are aimed at changing lifestyle and eating behavior, to prevent, manage, and 
      potentially reverse metabolic disorders. Recently, the ketogenic diet (KD) has 
      been proposed as a promising dietary intervention for the treatment of metabolic 
      and cardiovascular risk factors related to obesity in adults, and a possible 
      beneficial role has also been proposed in children. KD is very low in 
      carbohydrate, high in fat, and moderate to high in protein that may have the 
      potential to promote weight loss and improve lipidic derangement, glycemic 
      control, and insulin sensitivity. In this review, we present metabolic disorders 
      on glycemic and lipidic control in children and adolescents with obesity and 
      indication of KD in pediatrics, discussing the role of KD as a therapeutic tool 
      for metabolic derangement. The results of this review may suggest the validity of 
      KD and the need to further research its potential to address metabolic risk 
      factors in pediatric obesity.
FAU - Calcaterra, Valeria
AU  - Calcaterra V
AUID- ORCID: 0000-0002-2137-5974
AD  - Pediatric and Adolescent Unit, Department of Internal Medicine, University of 
      Pavia, 27100 Pavia, Italy.
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
FAU - Verduci, Elvira
AU  - Verduci E
AUID- ORCID: 0000-0003-2111-3111
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
AD  - Department of Health Sciences, University of Milano, 20142 Milano, Italy.
FAU - Pascuzzi, Martina Chiara
AU  - Pascuzzi MC
AUID- ORCID: 0000-0003-3549-498X
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
AD  - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, 
      20157 Milan, Italy.
FAU - Magenes, Vittoria Carlotta
AU  - Magenes VC
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
AD  - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, 
      20157 Milan, Italy.
FAU - Fiore, Giulia
AU  - Fiore G
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
AD  - Department of Health Sciences, University of Milano, 20142 Milano, Italy.
FAU - Di Profio, Elisabetta
AU  - Di Profio E
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
AD  - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, 
      20157 Milan, Italy.
FAU - Tenuta, Elisavietta
AU  - Tenuta E
AD  - Pediatric and Adolescent Unit, Department of Internal Medicine, University of 
      Pavia, 27100 Pavia, Italy.
FAU - Bosetti, Alessandra
AU  - Bosetti A
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
FAU - Todisco, Carolina Federica
AU  - Todisco CF
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
AD  - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, 
      20157 Milan, Italy.
FAU - D'Auria, Enza
AU  - D'Auria E
AUID- ORCID: 0000-0003-2750-5810
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
AD  - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, 
      20157 Milan, Italy.
FAU - Zuccotti, Gianvincenzo
AU  - Zuccotti G
AUID- ORCID: 0000-0002-2795-9874
AD  - Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
AD  - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, 
      20157 Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210816
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Diabetes Mellitus, Type 2/*diet therapy
MH  - *Diet, Ketogenic
MH  - Humans
MH  - Insulin Resistance
MH  - Metabolic Diseases/*diet therapy
MH  - Pediatric Obesity/*diet therapy
PMC - PMC8400548
OTO - NOTNLM
OT  - diabetes
OT  - insulin resistance
OT  - ketogenic diet
OT  - lipids
OT  - obesity
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/10/16 06:00
PMCR- 2021/08/16
CRDT- 2021/08/27 01:22
PHST- 2021/06/21 00:00 [received]
PHST- 2021/07/22 00:00 [revised]
PHST- 2021/08/12 00:00 [accepted]
PHST- 2021/08/27 01:22 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/08/16 00:00 [pmc-release]
AID - nu13082805 [pii]
AID - nutrients-13-02805 [pii]
AID - 10.3390/nu13082805 [doi]
PST - epublish
SO  - Nutrients. 2021 Aug 16;13(8):2805. doi: 10.3390/nu13082805.