PMID- 34445051
OWN - NLM
STAT- MEDLINE
DCOM- 20210922
LR  - 20220310
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 8
DP  - 2021 Aug 23
TI  - Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of 
      Intrauterine Growth Restriction in the Non-Human Primate.
LID - 10.3390/nu13082892 [doi]
LID - 2892
AB  - Intrauterine growth restriction (IUGR) is associated with reduced placental amino 
      acid transport (AAT). However, it remains to be established if changes in AAT 
      contribute to restricted fetal growth. We hypothesized that reduced in vivo 
      placental AAT precedes the development of IUGR in baboons with maternal nutrient 
      restriction (MNR). Baboons were fed either a control (ad libitum) or MNR diet 
      (70% of control diet) from gestational day (GD) 30. At GD 140, in vivo 
      transplacental AA transport was measured by infusing nine ((13))C- or 
      ((2))H-labeled essential amino acids (EAAs) as a bolus into the maternal 
      circulation at cesarean section. A fetal vein-to-maternal artery mole percent 
      excess ratio for each EAA was measured. Microvillous plasma membrane (MVM) system 
      A and system L transport activity were determined. Fetal and placental weights 
      were not significantly different between MNR and control. In vivo, the fetal 
      vein-to-maternal artery mole percent excess ratio was significantly decreased for 
      tryptophan in MNR. MVM system A and system L activity was markedly reduced in 
      MNR. Reduction of in vivo placental amino acid transport precedes fetal growth 
      restriction in the non-human primate, suggesting that reduced placental amino 
      acid transfer may contribute to IUGR.
FAU - Rosario, Fredrick J
AU  - Rosario FJ
AD  - Division of Reproductive Sciences, Department of Obstetrics and Gynecology, 
      University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
FAU - Kramer, Anita
AU  - Kramer A
AD  - Division of Reproductive Sciences, Department of Obstetrics and Gynecology, 
      University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
FAU - Li, Cun
AU  - Li C
AD  - Texas Pregnancy and Life-Course Health Center, Department of Animal Sciences, 
      University of Wyoming, Laramie, WY 82071, USA.
AD  - Southwest National Primate Research Center, Texas Biomedical Research Institute, 
      San Antonio, TX 78227, USA.
FAU - Galan, Henry L
AU  - Galan HL
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, 
      University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
FAU - Powell, Theresa L
AU  - Powell TL
AD  - Division of Reproductive Sciences, Department of Obstetrics and Gynecology, 
      University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
AD  - Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz 
      Medical Campus, Aurora, CO 80045, USA.
FAU - Nathanielsz, Peter W
AU  - Nathanielsz PW
AD  - Texas Pregnancy and Life-Course Health Center, Department of Animal Sciences, 
      University of Wyoming, Laramie, WY 82071, USA.
AD  - Southwest National Primate Research Center, Texas Biomedical Research Institute, 
      San Antonio, TX 78227, USA.
FAU - Jansson, Thomas
AU  - Jansson T
AD  - Division of Reproductive Sciences, Department of Obstetrics and Gynecology, 
      University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
LA  - eng
GR  - P51 OD011133/OD/NIH HHS/United States
GR  - P01-HD-21350/National Institute of Child Health and Human Development/
PT  - Journal Article
DEP - 20210823
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Amino Acid Transport System A)
RN  - 0 (Amino Acid Transport System L)
RN  - 0 (Amino Acids)
SB  - IM
MH  - Amino Acid Transport System A/*metabolism
MH  - Amino Acid Transport System L/*metabolism
MH  - Amino Acids/*metabolism
MH  - Animals
MH  - Biological Transport
MH  - *Diet, Protein-Restricted
MH  - Disease Models, Animal
MH  - Female
MH  - Fetal Development
MH  - Fetal Growth Retardation/*etiology/metabolism/physiopathology
MH  - Gestational Age
MH  - Maternal Nutritional Physiological Phenomena
MH  - *Maternal-Fetal Exchange
MH  - Papio
MH  - Placenta/*metabolism
MH  - Pregnancy
PMC - PMC8401823
OTO - NOTNLM
OT  - amino acids
OT  - fetal growth restriction
OT  - maternal-fetal exchange
OT  - neutral
OT  - trophoblast
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/09/23 06:00
PMCR- 2021/08/23
CRDT- 2021/08/27 01:22
PHST- 2021/07/26 00:00 [received]
PHST- 2021/08/12 00:00 [revised]
PHST- 2021/08/19 00:00 [accepted]
PHST- 2021/08/27 01:22 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/09/23 06:00 [medline]
PHST- 2021/08/23 00:00 [pmc-release]
AID - nu13082892 [pii]
AID - nutrients-13-02892 [pii]
AID - 10.3390/nu13082892 [doi]
PST - epublish
SO  - Nutrients. 2021 Aug 23;13(8):2892. doi: 10.3390/nu13082892.