PMID- 34445143
OWN - NLM
STAT- MEDLINE
DCOM- 20210915
LR  - 20210915
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 16
DP  - 2021 Aug 5
TI  - Tolerogenic Dendritic Cell-Based Approaches in Autoimmunity.
LID - 10.3390/ijms22168415 [doi]
LID - 8415
AB  - Dendritic cells (DCs) dictate the outcomes of tissue-specific immune responses. 
      In the context of autoimmune diseases, DCs instruct T cells to respond to 
      antigens (Ags), including self-Ags, leading to organ damage, or to becoming 
      regulatory T cells (Tregs) promoting and perpetuating immune tolerance. DCs can 
      acquire tolerogenic properties in vitro and in vivo in response to several 
      stimuli, a feature that opens the possibility to generate or to target DCs to 
      restore tolerance in autoimmune settings. We present an overview of the different 
      subsets of human DCs and of the regulatory mechanisms associated with tolerogenic 
      (tol)DC functions. We review the role of DCs in the induction of tissue-specific 
      autoimmunity and the current approaches exploiting tolDC-based therapies or 
      targeting DCs in vivo for the treatment of autoimmune diseases. Finally, we 
      discuss limitations and propose future investigations for improving the knowledge 
      on tolDCs for future clinical assessment to revert and prevent autoimmunity. The 
      continuous expansion of tolDC research areas will lead to improving the 
      understanding of the role that DCs play in the development and treatment of 
      autoimmunity.
FAU - Passeri, Laura
AU  - Passeri L
AD  - San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific 
      Institute, 20132 Milan, Italy.
AD  - San Raffaele Scientific Institute IRCCS, University Vita-Salute San Raffaele, 
      20132 Milan, Italy.
FAU - Marta, Fortunato
AU  - Marta F
AD  - San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific 
      Institute, 20132 Milan, Italy.
FAU - Bassi, Virginia
AU  - Bassi V
AD  - San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific 
      Institute, 20132 Milan, Italy.
AD  - San Raffaele Scientific Institute IRCCS, University Vita-Salute San Raffaele, 
      20132 Milan, Italy.
FAU - Gregori, Silvia
AU  - Gregori S
AD  - San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific 
      Institute, 20132 Milan, Italy.
LA  - eng
GR  - Tele21-G1/Fondazione Telethon/
GR  - RF-2016-02361372/The Italian Ministry of Health/
PT  - Journal Article
PT  - Review
DEP - 20210805
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/*immunology
MH  - Autoimmunity/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - T-Lymphocytes, Regulatory/immunology
PMC - PMC8395087
OTO - NOTNLM
OT  - autoimmune diseases
OT  - dendritic cells
OT  - tolerance
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/28 06:00
MHDA- 2021/09/16 06:00
PMCR- 2021/08/05
CRDT- 2021/08/27 01:23
PHST- 2021/06/05 00:00 [received]
PHST- 2021/08/02 00:00 [revised]
PHST- 2021/08/03 00:00 [accepted]
PHST- 2021/08/27 01:23 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/09/16 06:00 [medline]
PHST- 2021/08/05 00:00 [pmc-release]
AID - ijms22168415 [pii]
AID - ijms-22-08415 [pii]
AID - 10.3390/ijms22168415 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Aug 5;22(16):8415. doi: 10.3390/ijms22168415.