PMID- 34447656
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211123
IS  - 1311-0160 (Print)
IS  - 2199-5761 (Electronic)
IS  - 1311-0160 (Linking)
VI  - 24
IP  - 1
DP  - 2021 Jun
TI  - Dual Effect of the GHRL Gene Variant in the Molecular Pathogenesis of Obesity.
PG  - 27-34
LID - 10.2478/bjmg-2021-0011 [doi]
AB  - Obesity is as a global health problem due to its interaction with complex chronic 
      disorders such as cardiovascular disorders, type 2 diabetes mellitus (T2DM) and 
      cancer. Despite the fact that pathogenesis of obesity is not yet clearly 
      understood, it is associated with a combination of psychological, environmental 
      and various genetic factors. Here, employing a case-control design, we aimed to 
      examine the effects of the GHRL c.152C>T (p.Arg51Gln) (rs34911341) and c.214G>T 
      (p.Leu72Met) (rs696217) markers on susceptibility to obesity in a Turkish-Cypriot 
      population, as well as to evaluate whether these markers affect biochemical 
      parameters and show their putative functional consequences. This study involved 
      211 Turkish-Cypriot subjects (106 obese and 95 non obese). Genotyping for the 
      GHRL gene polymorphisms was performed by polymerase chain reaction-restriction 
      fragment length polymorphism (PCR-RFLP) analysis. Our results indicate that the 
      GHRL Leu72Met polymorphism was found to be significantly higher in obese 
      patients, with respect to genotypic (p = 0.0012) and allelic (p = 0.0005) 
      frequencies. Strikingly, the rs696217 GT genotype (heterozygous) had 
      significantly lower serum high-density lipoprotein cholesterol (HDL-C) (p = 
      0.015) than GG (wild type) genotypes. Overall, Leu72Met susceptibility variant 
      may be considered as risk and crucial marker for both obesity and cholesterol 
      metabolism in the community of Turkish-Cypriots. Thus, the dual effect of the 
      GHRL gene Leu72Met variant may be used for clinical diagnosis.
CI  - (c) 2021 Becer E, Ergoren MC, published by Sciendo.
FAU - Becer, E
AU  - Becer E
AD  - Department of Biochemistry, Faculty of Pharmacy, Near East University, Nicosia, 
      Cyprus.
AD  - DESAM Research Institute, Near East University, Nicosia, Cyprus.
FAU - Ergoren, M C
AU  - Ergoren MC
AD  - DESAM Research Institute, Near East University, Nicosia, Cyprus.
AD  - Department of Medical Biology, Faculty of Medicine, Near East University, 
      Nicosia, Cyprus.
LA  - eng
PT  - Journal Article
DEP - 20210727
PL  - Poland
TA  - Balkan J Med Genet
JT  - Balkan journal of medical genetics : BJMG
JID - 9806959
PMC - PMC8366472
OTO - NOTNLM
OT  - Arg51Gln
OT  - GHRL gene
OT  - Ghrelin
OT  - Leu72 Met
OT  - Obesity
OT  - Turkish-Cypriot population
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/07/27
CRDT- 2021/08/27 06:57
PHST- 2021/08/27 06:57 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/07/27 00:00 [pmc-release]
AID - bjmg-2021-0011 [pii]
AID - 10.2478/bjmg-2021-0011 [doi]
PST - epublish
SO  - Balkan J Med Genet. 2021 Jul 27;24(1):27-34. doi: 10.2478/bjmg-2021-0011. 
      eCollection 2021 Jun.