PMID- 34447659
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211123
IS  - 1311-0160 (Print)
IS  - 2199-5761 (Electronic)
IS  - 1311-0160 (Linking)
VI  - 24
IP  - 1
DP  - 2021 Jun
TI  - Genetic Association of Solute Carrier Transporter Gene Variants with Metformin 
      Response.
PG  - 47-56
LID - 10.2478/bjmg-2021-0004 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated 
      blood glucose levels and is influenced by both genetic and environmental factors. 
      It is treated with various classes of oral antidiabetic drugs, however, response 
      to treatment is highly variable with patients failing to achieve adequate 
      glycemic control. Treatment response variability has been associated with single 
      nucleotide polymorphisms (SNPs) which influence the pharma-cokinetics and 
      pharmacodynamics of drug(s). The aim of this study was to evaluate the genetic 
      association of 17 SNPs and the response to metformin therapy in patients 
      diagnosed with diabetes from the indigenous Nguni population of South Africa. One 
      hundred and forty indigenous African patients diagnosed with T2DM were recruited 
      and genotyped using the MassARRAY(R) system. Therapeutic response of patients was 
      ascertained by a change in Hb A(1c). Two SNPs (rs1801282 and rs6265) were 
      monomorphic. All other variants were within the Hardy-Weinberg equilibrium (HWE). 
      The T allele of the SLC variant rs316009 [odds ratio (OR) = 0.25, 95% confidence 
      interval (95% CI) = 0.01-0.09, p value = 0.044] and the CT genotype of the PCK1 
      variant rs4810083 (OR = 2.80, 95% CI = 1.01-7.79, p value = 0.049) were 
      associated with an improved response to treatment after adjustment. No 
      association was observed with post Bonferroni correction. Moreover, this study 
      provides important additional data regarding possible associations between 
      genetic variants and metformin therapy outcomes. In addition, this is one of the 
      first studies providing genetic data from the understudied indigenous sub-Saharan 
      African populations.
CI  - (c) 2021 Abrahams-October Z, Xhakaza L, Pearce B, Mandisa Masilela C, Benjeddou M, 
      Vincent Adeniyi O, Johnson R, Jebio Ongole J, published by Sciendo.
FAU - Abrahams-October, Z
AU  - Abrahams-October Z
AD  - Precision Medicine Unit, Department of Biotechnology, Faculty of Natural 
      Sciences, University of the Western Cape, Bellville, South Africa.
FAU - Xhakaza, L
AU  - Xhakaza L
AD  - Precision Medicine Unit, Department of Biotechnology, Faculty of Natural 
      Sciences, University of the Western Cape, Bellville, South Africa.
FAU - Pearce, B
AU  - Pearce B
AD  - Precision Medicine Unit, Department of Biotechnology, Faculty of Natural 
      Sciences, University of the Western Cape, Bellville, South Africa.
FAU - Mandisa Masilela, C
AU  - Mandisa Masilela C
AD  - Precision Medicine Unit, Department of Biotechnology, Faculty of Natural 
      Sciences, University of the Western Cape, Bellville, South Africa.
FAU - Benjeddou, M
AU  - Benjeddou M
AD  - Precision Medicine Unit, Department of Biotechnology, Faculty of Natural 
      Sciences, University of the Western Cape, Bellville, South Africa.
FAU - Vincent Adeniyi, O
AU  - Vincent Adeniyi O
AD  - Department of Family Medicine, Walter Sisulu University, East London, South 
      Africa.
FAU - Johnson, R
AU  - Johnson R
AD  - South African Medical Research Council, Parow, Cape Town, South Africa.
AD  - Division of Medical Physiology, Faculty of Medicine and Health Sciences, 
      Stellenbosch University, Tygerberg, South Africa.
FAU - Jebio Ongole, J
AU  - Jebio Ongole J
AD  - Department of Family Medicine, Piet Retief Hospital, Mkhondo, Mpumalanga, South 
      Africa.
LA  - eng
PT  - Journal Article
DEP - 20210727
PL  - Poland
TA  - Balkan J Med Genet
JT  - Balkan journal of medical genetics : BJMG
JID - 9806959
PMC - PMC8366475
OTO - NOTNLM
OT  - SLC variants
OT  - Single nucleotide polymorphisms (SNPs)
OT  - South African cohort
OT  - Treatment response
OT  - Type 2 diabetes mellitus (T2DM)
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/07/27
CRDT- 2021/08/27 06:57
PHST- 2021/08/27 06:57 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/07/27 00:00 [pmc-release]
AID - bjmg-2021-0004 [pii]
AID - 10.2478/bjmg-2021-0004 [doi]
PST - epublish
SO  - Balkan J Med Genet. 2021 Jul 27;24(1):47-56. doi: 10.2478/bjmg-2021-0004. 
      eCollection 2021 Jun.