PMID- 34447661
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211123
IS  - 1311-0160 (Print)
IS  - 2199-5761 (Electronic)
IS  - 1311-0160 (Linking)
VI  - 24
IP  - 1
DP  - 2021 Jun
TI  - Mutation Status and Immunohistochemical Correlation of EGFR Mutations in 
      Gastrointestinal Stromal Tumors.
PG  - 67-72
LID - 10.2478/bjmg-2021-0006 [doi]
AB  - Being one of the leading causes of cancer deaths worldwide and their resistance 
      to conventional treatment methods, made gastrointestinal stromal tumors (GISTs) 
      one of the hot topics in medical research areas in the past decade. To 
      investigate molecular alterations underlying the tumor is of great importance to 
      be able to develop new, targeted treatment options. In this study, GIST samples 
      obtained from 40 Turkish patients were analyzed for actionable epidermal growth 
      factor receptor (EGFR) mutations that are related to treatment regimes in non 
      small cell lung cancer (NSCLC) to understand whether EGFR expression is altered 
      in GISTs. Established alterations in EGFR can make the use of tyrosine kinase 
      inhibitors possible, which are currently used in cancer therapy, especially in 
      NSCLC. Our results indicated that EGFR mutations are rare in GISTs. Further 
      research is needed to sequence whole coding regions of the gene to investigate 
      new actionable mutations in EGFR in an increased sample size.
CI  - (c) 2021 Ozkayalar H, Ergoren MC, Tuncel G, Kurt S, Cevik E, Ozemri Sag S, Yilmaz 
      Ozguven B, Kabukcuoglu F, Mocan G, Temel SG, published by Sciendo.
FAU - Ozkayalar, H
AU  - Ozkayalar H
AD  - Department of Pathology, Faculty of Medicine, Near East University, Northern 
      Nicosia, Cyprus.
FAU - Ergoren, M C
AU  - Ergoren MC
AD  - Department of Medical Biology, Faculty of Medicine, Near East University, 
      Northern Nicosia, Cyprus.
AD  - Research Center of Experimental Health Sciences (DESAM), Faculty of Medicine, 
      Near East University, Northern Nicosia, Cyprus.
FAU - Tuncel, G
AU  - Tuncel G
AD  - Department of Medical Biology, Faculty of Medicine, Near East University, 
      Northern Nicosia, Cyprus.
AD  - Research Center of Experimental Health Sciences (DESAM), Faculty of Medicine, 
      Near East University, Northern Nicosia, Cyprus.
FAU - Kurt, S
AU  - Kurt S
AD  - Department of Medical Genetics, Faculty of Medicine, Bursa Uludag University, 
      Bursa, Turkey.
FAU - Cevik, E
AU  - Cevik E
AD  - Department of Medical Genetics, Faculty of Medicine, Bursa Uludag University, 
      Bursa, Turkey.
FAU - Ozemri Sag, S
AU  - Ozemri Sag S
AD  - Department of Medical Genetics, Faculty of Medicine, Bursa Uludag University, 
      Bursa, Turkey.
FAU - Yilmaz Ozguven, B
AU  - Yilmaz Ozguven B
AD  - Department of Pathology, Sisli Hamidiye Etfal Education and Research Hospital, 
      University of Health Sciences, Istanbul, Turkey.
FAU - Kabukcuoglu, F
AU  - Kabukcuoglu F
AD  - Department of Pathology, Sisli Hamidiye Etfal Education and Research Hospital, 
      University of Health Sciences, Istanbul, Turkey.
FAU - Mocan, G
AU  - Mocan G
AD  - Department of Pathology, Faculty of Medicine, Near East University, Northern 
      Nicosia, Cyprus.
AD  - Department of Medical Biology, Faculty of Medicine, Near East University, 
      Northern Nicosia, Cyprus.
FAU - Temel, S G
AU  - Temel SG
AD  - Department of Medical Genetics, Faculty of Medicine, Bursa Uludag University, 
      Bursa, Turkey.
AD  - Department of Embryology and Histology, Faculty of Medicine, Bursa Uludag 
      University, Bursa, Turkey.
AD  - Department of Translational Medicine, Bursa Uludag University, Health Sciences 
      Institute, Bursa, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210727
PL  - Poland
TA  - Balkan J Med Genet
JT  - Balkan journal of medical genetics : BJMG
JID - 9806959
PMC - PMC8366477
OTO - NOTNLM
OT  - Epidermal growth factor receptor (EGFR) gene
OT  - Gastrointestinal stromal tumors (GISTs)
OT  - Targeted therapy
COIS- Conflict of interest Declaration of Interest. The authors report no conflicts of 
      interest. The authors alone are responsible for the content and writing of this 
      article.
EDAT- 2021/08/28 06:00
MHDA- 2021/08/28 06:01
PMCR- 2021/07/27
CRDT- 2021/08/27 06:57
PHST- 2021/08/27 06:57 [entrez]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/08/28 06:01 [medline]
PHST- 2021/07/27 00:00 [pmc-release]
AID - bjmg-2021-0006 [pii]
AID - 10.2478/bjmg-2021-0006 [doi]
PST - epublish
SO  - Balkan J Med Genet. 2021 Jul 27;24(1):67-72. doi: 10.2478/bjmg-2021-0006. 
      eCollection 2021 Jun.