PMID- 34448237
OWN - NLM
STAT- MEDLINE
DCOM- 20220119
LR  - 20220119
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Linking)
VI  - 74
IP  - 6
DP  - 2021 Dec
TI  - Light Chain Deposition Disease: An Unusual Cause of Portal Hypertension.
PG  - 3546-3548
LID - 10.1002/hep.32118 [doi]
AB  - Light chain deposition disease (LCDD) is a rare entity that is generally 
      discovered in the setting of solid organ dysfunction. The monoclonal gammopathy 
      leads to abnormal deposition of light chains in tissues, most often manifested by 
      way of renal dysfunction. Other organ systems may also be affected, the liver 
      being the second-most common after the kidneys. Liver involvement rarely leads to 
      clinically significant disease, with few case reports in the literature. We 
      present the case of a patient referred to a hepatology clinic for the evaluation 
      of new-onset ascites resulting from portal hypertension secondary to LCDD 
      involving the liver.
CI  - (c) 2021 by the American Association for the Study of Liver Diseases.
FAU - Plummer, Molly Delk
AU  - Plummer MD
AUID- ORCID: 0000-0002-5825-9192
AD  - Division of Abdominal Transplant, Tulane University School of Medicine, New 
      Orleans, LA.
FAU - Regenstein, Fredric
AU  - Regenstein F
AD  - Division of Abdominal Transplant, Tulane University School of Medicine, New 
      Orleans, LA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20211023
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Adult
MH  - Fatal Outcome
MH  - Humans
MH  - Hypertension, Portal/*etiology/pathology
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Kidney Transplantation/adverse effects
MH  - Liver/pathology
MH  - Male
MH  - Paraproteinemias/*complications/pathology
EDAT- 2021/08/28 06:00
MHDA- 2022/01/20 06:00
CRDT- 2021/08/27 07:11
PHST- 2021/07/13 00:00 [revised]
PHST- 2020/11/04 00:00 [received]
PHST- 2021/07/31 00:00 [accepted]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2022/01/20 06:00 [medline]
PHST- 2021/08/27 07:11 [entrez]
AID - 10.1002/hep.32118 [doi]
PST - ppublish
SO  - Hepatology. 2021 Dec;74(6):3546-3548. doi: 10.1002/hep.32118. Epub 2021 Oct 23.