PMID- 34449321
OWN - NLM
STAT- MEDLINE
DCOM- 20220106
LR  - 20220106
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 142
DP  - 2021 Oct
TI  - Gut microbiota as the critical correlation of polycystic ovary syndrome and type 
      2 diabetes mellitus.
PG  - 112094
LID - S0753-3322(21)00877-5 [pii]
LID - 10.1016/j.biopha.2021.112094 [doi]
AB  - Gut microbiota forms a symbiotic relationship with the host and maintains the 
      ecological balance of the internal and external environment of the human body. 
      However, dysbiosis of the gut microbiota and immune deficiency, as well as 
      environmental changes, can destroy the host-microbial balance, leading to the 
      occurrence of a variety of diseases, such as polycystic ovary syndrome (PCOS), 
      type 2 diabetes mellitus (T2DM), and obesity. Meanwhile, diseases can also affect 
      gut microbiota, forming a vicious cycle. The role of the intestinal microbiota in 
      different diseases have been proven by several studies; however, as a common 
      target of PCOS and T2DM, there are few reports on the treatment of different 
      diseases through the regulation of intestinal microbiota as the critical 
      correlation. This review analyzed the common mechanisms of intestinal microbiota 
      in PCOS and T2DM, including the dysbiosis of gut microbiota, endotoxemia, 
      short-chain fatty acids, biotransformation of bile acids, and synthesis of amino 
      acid in regulating insulin resistance, obesity, chronic inflammation, and 
      mitochondrial dysfunction. The possible therapeutic effects of probiotics and/or 
      prebiotics, fecal microbiota transplantation, bariatric surgery, dietary 
      intervention, drug treatment, and other treatments targeted at regulating 
      intestinal microbiota were also elucidated.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Duan, Liyun
AU  - Duan L
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China; China Academy of Chinese Medical 
      Sciences, Beijing 100700, China.
FAU - An, Xuedong
AU  - An X
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China; China Academy of Chinese Medical 
      Sciences, Beijing 100700, China.
FAU - Zhang, Yuehong
AU  - Zhang Y
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China; China Academy of Chinese Medical 
      Sciences, Beijing 100700, China.
FAU - Jin, De
AU  - Jin D
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China; China Academy of Chinese Medical 
      Sciences, Beijing 100700, China.
FAU - Zhao, Shenghui
AU  - Zhao S
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China; Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Zhou, Rongrong
AU  - Zhou R
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China; China Academy of Chinese Medical 
      Sciences, Beijing 100700, China.
FAU - Duan, Yingying
AU  - Duan Y
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China; Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Zhang, Yuqing
AU  - Zhang Y
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China; China Academy of Chinese Medical 
      Sciences, Beijing 100700, China.
FAU - Liu, Xinmin
AU  - Liu X
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China. Electronic address: 
      beijingliuxm@163.com.
FAU - Lian, Fengmei
AU  - Lian F
AD  - Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing 100053, China. Electronic address: Lfm565@sohu.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210826
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Prebiotics)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/microbiology/*physiopathology
MH  - Dysbiosis/complications/therapy
MH  - Fecal Microbiota Transplantation/methods
MH  - Female
MH  - Gastrointestinal Microbiome/*physiology
MH  - Humans
MH  - Polycystic Ovary Syndrome/microbiology/*physiopathology
MH  - Prebiotics/administration & dosage
MH  - Probiotics/administration & dosage
OTO - NOTNLM
OT  - Gut microbiota
OT  - Polycystic ovary syndrome
OT  - Simultaneous treatment
OT  - Type 2 diabetes mellitus
EDAT- 2021/08/28 06:00
MHDA- 2022/01/07 06:00
CRDT- 2021/08/27 17:19
PHST- 2021/04/25 00:00 [received]
PHST- 2021/08/05 00:00 [revised]
PHST- 2021/08/20 00:00 [accepted]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2022/01/07 06:00 [medline]
PHST- 2021/08/27 17:19 [entrez]
AID - S0753-3322(21)00877-5 [pii]
AID - 10.1016/j.biopha.2021.112094 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2021 Oct;142:112094. doi: 10.1016/j.biopha.2021.112094. Epub 
      2021 Aug 26.