PMID- 34450202
OWN - NLM
STAT- MEDLINE
DCOM- 20211014
LR  - 20211014
IS  - 1873-6971 (Electronic)
IS  - 0367-326X (Linking)
VI  - 154
DP  - 2021 Oct
TI  - Bioactive flavonoids and stilbenes from the leaf of Morus alba var. multicaulis.
PG  - 105018
LID - S0367-326X(21)00193-3 [pii]
LID - 10.1016/j.fitote.2021.105018 [doi]
AB  - Twenty-two flavonoids and stilbenes (1-22) were obtained from the leaf of Morus 
      alba var. multicaulis. Among them, morusalbanosides A (1), B(1) (2), and B(2) (3) 
      were new compounds. Moreover, compounds 1, 3, 4-11, 15-18, and 22 displayed 
      inhibitory effects on triglyceride (TG) accumulation in HepG2 cells in a 
      concentration dependent manner. Furthermore, compounds 1, 3, 11, and 22 could 
      activate the phosphorylation of AMP-activated protein kinase alpha (AMPKalpha), reduce 
      the synthesis of TG by inhibiting the expression of fatty acid synthase (FAS) and 
      stearoyl-CoA desaturase 1 (SCD1). While, only compounds 1 and 11 could promote 
      the phosphorylation of acetyl-CoA carboxylase 1 (ACC1) and accelerate the 
      oxidation of fatty acids by up-regulating carnitine palmitoyltransferase 1A 
      (CPT1A). In brief, this study found that most of the researched flavonoids and 
      stilbenes could regulate TG metabolism in vitro. They might play the role by 
      up-regulating phosphorylation of AMPKalpha, inhibiting TG biosynthesis, and promoting 
      the oxidation of fatty acids.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Hao, Mimi
AU  - Hao M
AD  - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, 
      Jinghai District, 301617 Tianjin, China.
FAU - Huang, Peijian
AU  - Huang P
AD  - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, 
      Jinghai District, 301617 Tianjin, China.
FAU - Ruan, Jingya
AU  - Ruan J
AD  - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, 
      Jinghai District, 301617 Tianjin, China.
FAU - Sun, Fan
AU  - Sun F
AD  - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, 
      Jinghai District, 301617 Tianjin, China.
FAU - Han, Lifeng
AU  - Han L
AD  - Institute of TCM, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu 
      Road, West Area, Tuanbo New Town, Jinghai District, 301617 Tianjin, China.
FAU - Liu, Mengyang
AU  - Liu M
AD  - Institute of TCM, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu 
      Road, West Area, Tuanbo New Town, Jinghai District, 301617 Tianjin, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, 
      Jinghai District, 301617 Tianjin, China; Institute of TCM, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, 
      Jinghai District, 301617 Tianjin, China. Electronic address: 
      zhwwxzh@tjutcm.edu.cn.
FAU - Wang, Tao
AU  - Wang T
AD  - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, 
      Jinghai District, 301617 Tianjin, China; Institute of TCM, Tianjin University of 
      Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, 
      Jinghai District, 301617 Tianjin, China. Electronic address: 
      wangtao@tjutcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210825
PL  - Netherlands
TA  - Fitoterapia
JT  - Fitoterapia
JID - 16930290R
RN  - 0 (Flavonoids)
RN  - 0 (Phytochemicals)
RN  - 0 (Stilbenes)
RN  - 0 (Triglycerides)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/metabolism
MH  - China
MH  - Flavonoids/isolation & purification/*pharmacology
MH  - Hep G2 Cells
MH  - Humans
MH  - Lipid Metabolism/*drug effects
MH  - Molecular Structure
MH  - Morus/*chemistry
MH  - Phosphorylation/drug effects
MH  - Phytochemicals/isolation & purification/pharmacology
MH  - Plant Leaves/chemistry
MH  - Stilbenes/isolation & purification/*pharmacology
MH  - Triglycerides/metabolism
OTO - NOTNLM
OT  - AMPKalpha
OT  - HepG2 cells
OT  - Morus alba Linn. var. multicaulis (Perr.) Loudon leaf
OT  - Morusalbanoside
OT  - Triglyceride
EDAT- 2021/08/28 06:00
MHDA- 2021/10/15 06:00
CRDT- 2021/08/27 20:13
PHST- 2021/07/05 00:00 [received]
PHST- 2021/08/11 00:00 [revised]
PHST- 2021/08/12 00:00 [accepted]
PHST- 2021/08/28 06:00 [pubmed]
PHST- 2021/10/15 06:00 [medline]
PHST- 2021/08/27 20:13 [entrez]
AID - S0367-326X(21)00193-3 [pii]
AID - 10.1016/j.fitote.2021.105018 [doi]
PST - ppublish
SO  - Fitoterapia. 2021 Oct;154:105018. doi: 10.1016/j.fitote.2021.105018. Epub 2021 
      Aug 25.