PMID- 34451181
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210831
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 13
IP  - 16
DP  - 2021 Aug 9
TI  - Binary Graft of Poly(N-vinylcaprolactam) and Poly(acrylic acid) onto Chitosan 
      Hydrogels Using Ionizing Radiation for the Retention and Controlled Release of 
      Therapeutic Compounds.
LID - 10.3390/polym13162641 [doi]
LID - 2641
AB  - In this study, we carried out the synthesis of a thermo- and pH-sensitive binary 
      graft, based on N-vinylcaprolactam (NVCL) and pH sensitive acrylic acid (AAc) 
      monomers, onto chitosan gels (net-CS) by ionizing radiation. Pre-oxidative 
      irradiation and direct methods were examined, and materials obtained were 
      characterized by FTIR-ATR, thermogravimetric analysis (TGA), scanning electron 
      microscopy (SEM), and swelling tests (equilibrium swelling time, critical pH, and 
      temperature). The best synthesis radiation method was the direct method, which 
      resulted in the maximum grafting percentages (~40%) at low doses (10-12 kGy). The 
      main goal of this study was the comparison of the swelling behavior and 
      physicochemical properties of net-CS with those of the binary system 
      (net-CS)-g-NVCL/AAc with the optimum grafting percentage (~30%). This produced a 
      material that showed an upper critical solution temperature (UCST) of 33.5  degrees C and 
      a critical pH value of 3.8, indicating the system is more hydrophilic at higher 
      temperatures and low pH values. Load and release studies were carried out using 
      diclofenac. The grafted system (32%) was able to load 19.3 mg g(-1) of diclofenac 
      and release about 95% within 200 min, in comparison to net-CS, which only 
      released 80% during the same period. When the grafted system was protonated 
      before diclofenac loading, it loaded 27.6 mg g(-1). However, the drug was 
      strongly retained in the material by electrostatic interactions and only released 
      about 20%.
FAU - Ortega, Alejandra
AU  - Ortega A
AD  - Departamento de Quimica de Radiaciones y Radioquimica, Instituto de Ciencias 
      Nucleares, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad 
      Universitaria, Ciudad de Mexico 04510, Mexico.
FAU - Sanchez, Abigail
AU  - Sanchez A
AD  - Departamento de Quimica de Radiaciones y Radioquimica, Instituto de Ciencias 
      Nucleares, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad 
      Universitaria, Ciudad de Mexico 04510, Mexico.
FAU - Burillo, Guillermina
AU  - Burillo G
AD  - Departamento de Quimica de Radiaciones y Radioquimica, Instituto de Ciencias 
      Nucleares, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad 
      Universitaria, Ciudad de Mexico 04510, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20210809
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC8397969
OTO - NOTNLM
OT  - chitosan crosslinked
OT  - diclofenac release
OT  - radiation grafting
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/29 06:00
MHDA- 2021/08/29 06:01
PMCR- 2021/08/09
CRDT- 2021/08/28 01:02
PHST- 2021/06/17 00:00 [received]
PHST- 2021/07/28 00:00 [revised]
PHST- 2021/07/28 00:00 [accepted]
PHST- 2021/08/28 01:02 [entrez]
PHST- 2021/08/29 06:00 [pubmed]
PHST- 2021/08/29 06:01 [medline]
PHST- 2021/08/09 00:00 [pmc-release]
AID - polym13162641 [pii]
AID - polymers-13-02641 [pii]
AID - 10.3390/polym13162641 [doi]
PST - epublish
SO  - Polymers (Basel). 2021 Aug 9;13(16):2641. doi: 10.3390/polym13162641.