PMID- 34451342
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210831
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 13
IP  - 16
DP  - 2021 Aug 20
TI  - Solubilization of Paclitaxel by Self-Assembled Amphiphilic Phospholipid-Mimetic 
      Polymers with Varied Hydrophobicity.
LID - 10.3390/polym13162805 [doi]
LID - 2805
AB  - 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers have been used as a 
      coating agent on medical devices and as a carrier in drug delivery systems 
      (DDSs). Paclitaxel (PTX) is a water-insoluble anticancer drug whose solubilizer 
      is necessary for administration. Block and random copolymers composed of 
      hydrophilic MPC and butyl methacrylate, named PMB, show different properties, 
      depending on the polymer sequence and MPC content. In the present study, we used 
      amphiphilic MPC polymers comprising hydrophobic dodecyl methacrylate (DMA). The 
      self-assembling properties and PTX solubilization of random and block 
      poly(MPC-co-DMA)s (rPMDs and bPMDs) with different compositions were examined and 
      compared. rPMDs with high DMA content formed large and relatively loose 
      self-assembled structures, which solubilized PTX. However, bPMDs formed small and 
      compact self-assembled structures with poor PTX solubilization. PTX solubilized 
      by PMB with small and loose self-assembled structures showed efficient drug 
      action, similar to free PTX; however, rPMDs fell short of demonstrating PTX 
      efficiency. Our results suggest that the self-assembling properties and the 
      hydrophobicity of amphiphilic MPC polymers largely affect PTX solubilization as 
      well as drug action, which is required to be controlled by the polymer sequence, 
      as well as the structure and composition of the hydrophobic monomer for efficient 
      DDS.
FAU - Kojima, Chie
AU  - Kojima C
AUID- ORCID: 0000-0002-2208-5784
AD  - Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture 
      University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
FAU - Hirose, Tomoka
AU  - Hirose T
AD  - Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture 
      University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
FAU - Katayama, Risa
AU  - Katayama R
AD  - Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture 
      University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
FAU - Matsumoto, Akikazu
AU  - Matsumoto A
AD  - Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture 
      University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210820
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC8398084
OTO - NOTNLM
OT  - MPC polymer
OT  - anticancer drug
OT  - drug delivery
OT  - hydrophobicity
OT  - polymer sequence
OT  - solubilization
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/29 06:00
MHDA- 2021/08/29 06:01
PMCR- 2021/08/20
CRDT- 2021/08/28 01:03
PHST- 2021/07/29 00:00 [received]
PHST- 2021/08/12 00:00 [revised]
PHST- 2021/08/18 00:00 [accepted]
PHST- 2021/08/28 01:03 [entrez]
PHST- 2021/08/29 06:00 [pubmed]
PHST- 2021/08/29 06:01 [medline]
PHST- 2021/08/20 00:00 [pmc-release]
AID - polym13162805 [pii]
AID - polymers-13-02805 [pii]
AID - 10.3390/polym13162805 [doi]
PST - epublish
SO  - Polymers (Basel). 2021 Aug 20;13(16):2805. doi: 10.3390/polym13162805.