PMID- 34452055
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210830
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 9
IP  - 8
DP  - 2021 Aug 21
TI  - Early Adverse Events between mRNA and Adenovirus-Vectored COVID-19 Vaccines in 
      Healthcare Workers.
LID - 10.3390/vaccines9080931 [doi]
LID - 931
AB  - Mass vaccination campaigns are important to control the COVID-19 pandemic, 
      however, adverse events (AEs) contribute to vaccine hesitancy. To investigate and 
      compare early AEs between the BNT162b2 mRNA and AZD1222 adenovirus-vectored 
      vaccines, recipients completed daily surveys about local and systemic reactions 
      for 7 days after each dose, respectively. A total of 80 and 1440 healthcare 
      workers received two doses of BNT162b2 and a first dose of AZD1222 vaccines. Any 
      AEs were reported by 52.5% of recipients after the first dose of BNT162b2, by 
      76.2% after the second dose of BNT162b2, and by 90.9% after the first dose of 
      AZD1222 (p < 0.001). Younger vaccinees had more AEs after the second dose of 
      BNT162b2 and first dose of AZD1222. Sex based differences were only observed in 
      the AZD1222 recipient group. No incidence of anaphylaxis or neurologic AEs were 
      observed. In conclusion, early AEs were mostly mild to moderate in severity and 
      generally transient in both BNT162b2 and AZD1222 groups. Sufficient explanation 
      of the expected AEs of the vaccine would be helpful for wider vaccination.
FAU - Wi, Yu-Mi
AU  - Wi YM
AUID- ORCID: 0000-0003-3625-3328
AD  - Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan 
      University, Changwon 51353, Korea.
FAU - Kim, Si-Ho
AU  - Kim SH
AUID- ORCID: 0000-0001-7763-8940
AD  - Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan 
      University, Changwon 51353, Korea.
FAU - Peck, Kyong-Ran
AU  - Peck KR
AUID- ORCID: 0000-0002-7464-9780
AD  - Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul 06351, Korea.
LA  - eng
PT  - Journal Article
DEP - 20210821
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC8402750
OTO - NOTNLM
OT  - AZD1222 vaccines
OT  - BNT162b2 mRNA vaccine
OT  - adverse event
OT  - coronavirus disease 2019
OT  - vaccine
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/29 06:00
MHDA- 2021/08/29 06:01
PMCR- 2021/08/21
CRDT- 2021/08/28 01:05
PHST- 2021/06/21 00:00 [received]
PHST- 2021/08/15 00:00 [revised]
PHST- 2021/08/16 00:00 [accepted]
PHST- 2021/08/28 01:05 [entrez]
PHST- 2021/08/29 06:00 [pubmed]
PHST- 2021/08/29 06:01 [medline]
PHST- 2021/08/21 00:00 [pmc-release]
AID - vaccines9080931 [pii]
AID - vaccines-09-00931 [pii]
AID - 10.3390/vaccines9080931 [doi]
PST - epublish
SO  - Vaccines (Basel). 2021 Aug 21;9(8):931. doi: 10.3390/vaccines9080931.