PMID- 34452899
OWN - NLM
STAT- MEDLINE
DCOM- 20210906
LR  - 20210906
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 51
IP  - 4
DP  - 2021 Jul
TI  - Composite Neuroblastoma Metastatic to a Lymph Node: The Novel Histopathologic 
      Diagnosis of a Unique Multiclonal Neoplasm.
PG  - 573-579
AB  - OBJECTIVE: Composite neuroblastoma is a tumor composed of multiple tumoral clones 
      within the neuroblastoma family. To date, establishing this unique 
      histopathologic diagnosis has required the evaluation of the primary tumor mass. 
      We report a case of composite neuroblastoma diagnosed by evaluation of a 
      metastatic lymph node. METHODS: One abdominal lymph node involved by tumor was 
      evaluated in a 6-year-old boy. The primary abdominal mass was not examined. 
      Following histopathologic examination, clonality studies using comparative 
      genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) were 
      also performed. RESULTS: Two distinct tumor components were identified by 
      histopathologic evaluation and classified as differentiating neuroblastoma 
      (component A) and poorly differentiated neuroblastoma (component B). Based on the 
      patient's age, each clone was further classified as Unfavorable Histology. The 
      presence of these two different tumoral clones was confirmed by CGH and FISH. 
      CONCLUSION: This case affirms the histopathologic approach to evaluating 
      composite tumors, as established by the International Neuroblastoma Pathology 
      Classification (INPC) model for ganglioneuroblastoma, nodular tumors. Also, when 
      both components are metastatic, this case demonstrates that composite tumors can 
      be diagnosed by the evaluation of metastatic lesions alone. Finally, it supports 
      the addition of composite neuroblastoma to a future version of the INPC.
CI  - (c) 2021 by the Association of Clinical Scientists, Inc.
FAU - Kurtz, Justin L
AU  - Kurtz JL
AD  - Stanford University School of Medicine, Department of Pathology, Stanford, CA, 
      USA.
FAU - Shimada, Hiroyuki
AU  - Shimada H
AD  - Stanford University School of Medicine, Department of Pathology, Stanford, CA, 
      USA.
FAU - Hazard, Florette K
AU  - Hazard FK
AD  - Stanford University School of Medicine, Department of Pathology, Stanford, CA, 
      USA hazard@stanford.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
SB  - IM
MH  - Abdominal Neoplasms/*pathology/surgery
MH  - Child
MH  - Ganglioneuroblastoma/*secondary/surgery
MH  - Humans
MH  - Lymph Nodes/*pathology/surgery
MH  - Male
MH  - Prognosis
OTO - NOTNLM
OT  - composite neuroblastoma
OT  - lymph node
OT  - metastatic
OT  - nodular ganglioneuroblastoma
EDAT- 2021/08/29 06:00
MHDA- 2021/09/07 06:00
CRDT- 2021/08/28 05:31
PHST- 2021/08/28 05:31 [entrez]
PHST- 2021/08/29 06:00 [pubmed]
PHST- 2021/09/07 06:00 [medline]
AID - 51/4/573 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2021 Jul;51(4):573-579.