PMID- 34455918
OWN - NLM
STAT- MEDLINE
DCOM- 20211207
LR  - 20220204
IS  - 2165-5987 (Electronic)
IS  - 2165-5979 (Print)
IS  - 2165-5979 (Linking)
VI  - 12
IP  - 1
DP  - 2021 Dec
TI  - A novel circular RNA circPPFIA1 promotes laryngeal squamous cell carcinoma 
      progression through sponging miR-340-3p and regulating ELK1 expression.
PG  - 5220-5230
LID - 10.1080/21655979.2021.1959866 [doi]
AB  - Abnormal expression of circular RNA (circRNA) is closely related to the 
      occurrence and development of many cancers. By screening the expression of 
      circRNA, we identified a novel circRNA termed as has_circ_0023326 in laryngeal 
      squamous cell carcinoma (LSCC). We verified the expression of circPPFIA1 and 
      found that it was upregulated in LSCC tissues compared to the adjacent normal 
      tissues. Functional studies were carried out to detect the effect of circPPFIA1 
      expression on the phenotype of LSCC cells. These results suggest that circPPFIA1 
      knockdown can suppress the proliferation, migration, and invasion of LSCC cells, 
      while circPPFIA1 overexpression can promote these processes. Mechanistically, 
      miR-340-3p was predicted to be the target miRNA sponged by circPPFIA1 as 
      confirmed through the luciferase assay and rescue experiments. In addition, 
      miR-340-3p was found to target ELK1 and inhibit its expression. Taken together, 
      circPPFIA1 promotes the progression of LSCC via the miR-340-3p/ELK1 signaling 
      axis, which may serve as a novel prognostic or therapeutic target for LSCC.
FAU - Shuang, Yu
AU  - Shuang Y
AUID- ORCID: 0000-0002-7940-9620
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of 
      Tianjin Medical University, Tianjin, P.R. China.
FAU - Liu, Jing
AU  - Liu J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of 
      Tianjin Medical University, Tianjin, P.R. China.
FAU - Niu, Juntao
AU  - Niu J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of 
      Tianjin Medical University, Tianjin, P.R. China.
FAU - Guo, Wenyu
AU  - Guo W
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of 
      Tianjin Medical University, Tianjin, P.R. China.
FAU - Li, Chao
AU  - Li C
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of 
      Tianjin Medical University, Tianjin, P.R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Bioengineered
JT  - Bioengineered
JID - 101581063
RN  - 0 (ELK1 protein, human)
RN  - 0 (MIRN340 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Circular)
RN  - 0 (ets-Domain Protein Elk-1)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Disease Progression
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/metabolism/pathology
MH  - Mice
MH  - MicroRNAs/*genetics/metabolism
MH  - RNA, Circular/*genetics/metabolism
MH  - Squamous Cell Carcinoma of Head and Neck/*genetics/metabolism/pathology
MH  - ets-Domain Protein Elk-1/*genetics/metabolism
PMC - PMC8806628
OTO - NOTNLM
OT  - Circppfia1
OT  - ceRNA
OT  - elk1
OT  - lscc
OT  - miR-340-3p
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2021/08/31 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/08/30
CRDT- 2021/08/30 05:25
PHST- 2021/08/30 05:25 [entrez]
PHST- 2021/08/31 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/08/30 00:00 [pmc-release]
AID - 1959866 [pii]
AID - 10.1080/21655979.2021.1959866 [doi]
PST - ppublish
SO  - Bioengineered. 2021 Dec;12(1):5220-5230. doi: 10.1080/21655979.2021.1959866.