PMID- 34458338
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210831
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Effect of SYTL3-SLC22A3 Variants, Their Haplotypes, and G x E Interactions on 
      Serum Lipid Levels and the Risk of Coronary Artery Disease and Ischaemic Stroke.
PG  - 713068
LID - 10.3389/fcvm.2021.713068 [doi]
LID - 713068
AB  - Background: The current study aimed to investigate the effects of 
      synaptotagmin-like 3 (SYTL3) and solute carrier family 22 member 3 (SLC22A3) 
      single nucleotide polymorphisms (SNPs) and gene-environment (G x E) interactions 
      on blood lipid levels as well as the risk of coronary artery disease (CAD) and 
      ischaemic stroke (IS) in the Southern Chinese Han population. Methods: The 
      genetic makeup of 6 SYTL3-SLC22A3 SNPs in 2269 unrelated participants (controls, 
      755; CAD, 758 and IS, 756) of Chinese Han ethnicity was detected by the 
      next-generation sequencing techniques. Results: The allele and genotype 
      frequencies of the SYTL3 rs2129209 and SLC22A3 rs539298 SNPs were significantly 
      different between the case and control groups. The SLC22A3 rs539298 SNP was 
      correlated with total cholesterol (TC) levels in controls, the rs539298G allele 
      carriers maintained lower TC levels than the rs539298G allele non-carriers. At 
      the same time, the SLC22A3 rs539298 SNP interacted with alcohol consumption 
      reduced the risk of CAD and IS. The SYTL3-SLC22A3 A-C-A-A-A-A, G-T-C-G-C-A and 
      A-T-A-A-C-A haplotypes increased and the A-C-A-A-C-G haplotype reduced the risk 
      of CAD, whereas the SYTL3-SLC22A3 A-C-A-A-A-A, G-T-C-G-A-G and A-T-A-A-C-A 
      haplotypes increased and the A-C-A-A-A-G and A-C-A-A-C-G haplotypes reduced the 
      risk of IS. In addition, several SNPs interacted with alcohol consumption, body 
      mass index >/= 24 kg/m(2) and cigarette smoking to affect serum lipid parameters 
      such as triglyceride, high-density lipoprotein cholesterol, TC, and 
      apolipoprotein A1 levels. Conclusions: Several SYTL3-SLC22A3 variants, especially 
      the rs539298 SNP, several haplotypes, and G x E interactions, were related to 
      blood lipid parameters and the risk of CAD and IS in the Southern Chinese Han 
      population.
CI  - Copyright (c) 2021 Zheng, Yin, Cao, Chen, Wu and Huang.
FAU - Zheng, Peng-Fei
AU  - Zheng PF
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, China.
FAU - Yin, Rui-Xing
AU  - Yin RX
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, China.
FAU - Cao, Xiao-Li
AU  - Cao XL
AD  - Department of Neurology, The First Affiliated Hospital, Guangxi Medical 
      University, Nanning, China.
FAU - Chen, Wu-Xian
AU  - Chen WX
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, China.
FAU - Wu, Jin-Zhen
AU  - Wu JZ
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, China.
FAU - Huang, Feng
AU  - Huang F
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, China.
LA  - eng
PT  - Journal Article
DEP - 20210812
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8387813
OTO - NOTNLM
OT  - SLC22A3
OT  - SYTL3
OT  - coronary artery disease
OT  - haplotype
OT  - ischaemic stroke
OT  - lipids
OT  - single nucleotide polymorphism
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/31 06:00
MHDA- 2021/08/31 06:01
PMCR- 2021/01/01
CRDT- 2021/08/30 06:02
PHST- 2021/05/21 00:00 [received]
PHST- 2021/07/21 00:00 [accepted]
PHST- 2021/08/30 06:02 [entrez]
PHST- 2021/08/31 06:00 [pubmed]
PHST- 2021/08/31 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.713068 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Aug 12;8:713068. doi: 10.3389/fcvm.2021.713068. 
      eCollection 2021.