PMID- 34458761
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210831
IS  - 2633-0679 (Electronic)
IS  - 2633-0679 (Linking)
VI  - 1
IP  - 4
DP  - 2020 Oct 1
TI  - Harnessing the PD-L1 interface peptide for positron emission tomography imaging 
      of the PD-1 immune checkpoint.
PG  - 214-224
LID - 10.1039/d0cb00070a [doi]
AB  - Interface peptides that mediate protein-protein interactions (PPI) are a class of 
      important lead compounds for designing PPI inhibitors. However, their potential 
      as precursors for radiotracers has never been exploited. Here we report that the 
      interface peptides from programmed death-ligand 1 (PD-L1) can be used in positron 
      emission tomography (PET) imaging of programmed cell death 1 (PD-1) with high 
      accuracy and sensitivity. Moreover, the performance differentiation between 
      murine PD-L1 derived interface peptide (mPep-1) and human PD-L1 derived interface 
      peptide (hPep-1) as PET tracers for PD-1 unveiled an unprecedented role of a 
      non-critical residue in target binding, highlighting the significance of PET 
      imaging as a companion diagnostic in drug development. Collectively, this study 
      not only provided a first-of-its-kind peptide-based PET tracer for PD-1 but also 
      conveyed a unique paradigm for developing imaging agents for highly challenging 
      protein targets, which could be used to identify other protein biomarkers 
      involved in the PPI networks.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Hu, Kuan
AU  - Hu K
AUID- ORCID: 0000-0003-2448-2254
AD  - Department of Advanced Nuclear Medicine Sciences, National Institute of 
      Radiological Sciences, National Institutes for Quantum and Radiological Science 
      and Technology Chiba, 263-8555 Japan zhang.ming-rong@qst.go.jp.
FAU - Xie, Lin
AU  - Xie L
AD  - Department of Advanced Nuclear Medicine Sciences, National Institute of 
      Radiological Sciences, National Institutes for Quantum and Radiological Science 
      and Technology Chiba, 263-8555 Japan zhang.ming-rong@qst.go.jp.
FAU - Hanyu, Masayuki
AU  - Hanyu M
AD  - Department of Advanced Nuclear Medicine Sciences, National Institute of 
      Radiological Sciences, National Institutes for Quantum and Radiological Science 
      and Technology Chiba, 263-8555 Japan zhang.ming-rong@qst.go.jp.
FAU - Zhang, Yiding
AU  - Zhang Y
AD  - Department of Advanced Nuclear Medicine Sciences, National Institute of 
      Radiological Sciences, National Institutes for Quantum and Radiological Science 
      and Technology Chiba, 263-8555 Japan zhang.ming-rong@qst.go.jp.
FAU - Li, Lingyun
AU  - Li L
AD  - School of Chemistry and Chemical Engineering, Beijing Institute of Technology 
      Beijing 100081 P. R. China wangwz@bit.edu.cn.
FAU - Ma, Xiaohui
AU  - Ma X
AD  - Department of Vascular Surgery, General Hospital of People's Liberation Army 
      Beijing 100853 P. R. China.
FAU - Nagatsu, Kotaro
AU  - Nagatsu K
AD  - Department of Advanced Nuclear Medicine Sciences, National Institute of 
      Radiological Sciences, National Institutes for Quantum and Radiological Science 
      and Technology Chiba, 263-8555 Japan zhang.ming-rong@qst.go.jp.
FAU - Suzuki, Hisashi
AU  - Suzuki H
AD  - Department of Advanced Nuclear Medicine Sciences, National Institute of 
      Radiological Sciences, National Institutes for Quantum and Radiological Science 
      and Technology Chiba, 263-8555 Japan zhang.ming-rong@qst.go.jp.
FAU - Wang, Weizhi
AU  - Wang W
AUID- ORCID: 0000-0002-7310-4068
AD  - School of Chemistry and Chemical Engineering, Beijing Institute of Technology 
      Beijing 100081 P. R. China wangwz@bit.edu.cn.
FAU - Zhang, Ming-Rong
AU  - Zhang MR
AUID- ORCID: 0000-0002-3001-9605
AD  - Department of Advanced Nuclear Medicine Sciences, National Institute of 
      Radiological Sciences, National Institutes for Quantum and Radiological Science 
      and Technology Chiba, 263-8555 Japan zhang.ming-rong@qst.go.jp.
LA  - eng
PT  - Journal Article
DEP - 20200827
PL  - England
TA  - RSC Chem Biol
JT  - RSC chemical biology
JID - 101768727
PMC - PMC8341843
COIS- There are no conflicts to declare.
EDAT- 2021/08/31 06:00
MHDA- 2021/08/31 06:01
PMCR- 2020/08/27
CRDT- 2021/08/30 06:08
PHST- 2020/05/15 00:00 [received]
PHST- 2020/08/04 00:00 [accepted]
PHST- 2021/08/30 06:08 [entrez]
PHST- 2021/08/31 06:00 [pubmed]
PHST- 2021/08/31 06:01 [medline]
PHST- 2020/08/27 00:00 [pmc-release]
AID - d0cb00070a [pii]
AID - 10.1039/d0cb00070a [doi]
PST - epublish
SO  - RSC Chem Biol. 2020 Aug 27;1(4):214-224. doi: 10.1039/d0cb00070a. eCollection 
      2020 Oct 1.