PMID- 34459335
OWN - NLM
STAT- MEDLINE
DCOM- 20220428
LR  - 20220531
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 47
IP  - 2
DP  - 2022 Feb
TI  - Lack of Association between Monocyte Chemoattractant Protein-1 (MCP-1) Gene 
      Promoter Polymorphism and Behcet's Disease with and without Ocular Involvement in 
      Iranian Population: A Case-Control Study.
PG  - 312-316
LID - 10.1080/02713683.2021.1963785 [doi]
AB  - PURPOSE: This case-control study aimed to evaluate the possible association of 
      MCP-1 - 2518A/G genetic polymorphism with Behcet's disease (BD) in the Iranian 
      patients. MATERIALS AND METHODS: This study was performed in 135 Behcet's 
      patients (51 ocular and 84 non-ocular) and 79 healthy individuals. Peripheral 
      blood samples were genotyped for MCP-1 - 2518A/G using the PCR-RFLP technique. 
      RESULTS: The statistical analysis of MCP-1 - 2518A/G showed no significant 
      differences in genotype/allele frequencies between Behcet's patients and 
      controls. There was no significant association in genotype/allele frequencies 
      between either ocular or non-ocular BD patients and controls. Also, different 
      genotype/allele frequencies between ocular and non-ocular BD were not 
      statistically significant. CONCLUSIONS: In this study, with a threshold P-value 
      of 0.05 and an estimated power of 0.81 to detect a significant association (odds 
      ratio >/=1.2), we did not observe any association of this variant with Behcet's 
      disease.
FAU - Ghaffari Laleh, Maryam
AU  - Ghaffari Laleh M
AUID- ORCID: 0000-0002-5321-0824
AD  - Faculty of Natural Sciences, Center of Excellence for Biodiversity, University of 
      Tabriz, Tabriz, Iran.
FAU - Bonyadi, Mortaza
AU  - Bonyadi M
AD  - Faculty of Natural Sciences, Center of Excellence for Biodiversity, University of 
      Tabriz, Tabriz, Iran.
FAU - Shahriyari, Elham
AU  - Shahriyari E
AD  - Faculty of Natural Sciences, Center of Excellence for Biodiversity, University of 
      Tabriz, Tabriz, Iran.
FAU - Jabbarpoor Bonyadi, Mohammad Hossein
AU  - Jabbarpoor Bonyadi MH
AD  - Ocular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Soheilian, Masoud
AU  - Soheilian M
AUID- ORCID: 0000-0001-7508-426X
AD  - Ocular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Yaseri, Mehdi
AU  - Yaseri M
AUID- ORCID: 0000-0002-4066-873X
AD  - Department of Biostatistics and Epidemiology, Tehran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20210829
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - *Behcet Syndrome/epidemiology/genetics
MH  - Case-Control Studies
MH  - *Chemokine CCL2/genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Iran/epidemiology
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - -2518A/G polymorphism
OT  - Behcet's disease
OT  - CCL2 gene
OT  - Iran
OT  - MCP-1 gene
OT  - PCR-RFLP
OT  - ocular involvement
EDAT- 2021/08/31 06:00
MHDA- 2022/04/29 06:00
CRDT- 2021/08/30 08:43
PHST- 2021/08/31 06:00 [pubmed]
PHST- 2022/04/29 06:00 [medline]
PHST- 2021/08/30 08:43 [entrez]
AID - 10.1080/02713683.2021.1963785 [doi]
PST - ppublish
SO  - Curr Eye Res. 2022 Feb;47(2):312-316. doi: 10.1080/02713683.2021.1963785. Epub 
      2021 Aug 29.