PMID- 3446159
OWN - NLM
STAT- MEDLINE
DCOM- 19880506
LR  - 20190824
IS  - 0004-8291 (Print)
IS  - 0004-8291 (Linking)
VI  - 17
IP  - 5
DP  - 1987 Oct
TI  - Tc-99m tertiary butyl isonitrile: a preliminary clinical study of a new 
      myocardial imaging agent in patients with chest pain.
PG  - 480-4
AB  - Tc-99m is a preferred agent for nuclear imaging. Tc-99m tertiary butyl isonitrile 
      (Tc-99m-TBI) is the first of a family of lipophilic cations which allow effective 
      imaging of the human myocardium. Twenty-one patients scheduled for coronary 
      angiography for the investigation of their chest pain were studied after 
      injections of this tracer given during exercise, and on a separate visit, at 
      rest. Despite high uptake in the liver and transiently in the lungs, high quality 
      gated images were obtained allowing the assessment of both myocardial uptake and 
      wall motion. The findings corresponded closely with angiographic and 
      ventriculographic assessment of coronary artery disease and myocardial 
      infarction. Redistribution of Tc-99m-TBI was shown to occur in ischemic 
      myocardium analogous to that occurring with thallium-201 (TI-201). Similar agents 
      with more favourable properties may well replace TI-201 as the myocardial imaging 
      agent of choice in the near future.
FAU - Chatterton, B E
AU  - Chatterton BE
AD  - Royal Adelaide Hospital, SA.
FAU - Baker, R J
AU  - Baker RJ
FAU - Mahar, L J
AU  - Mahar LJ
FAU - Steele, P M
AU  - Steele PM
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust N Z J Med
JT  - Australian and New Zealand journal of medicine
JID - 1264322
RN  - 0 (Nitriles)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (technetium Tc 99m hexakis(tert-butylisonitrile))
RN  - 7440-26-8 (Technetium)
SB  - IM
MH  - Angina Pectoris/*diagnostic imaging
MH  - Coronary Angiography
MH  - Exercise Test
MH  - Female
MH  - Heart/*diagnostic imaging
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nitriles
MH  - *Organometallic Compounds
MH  - *Organotechnetium Compounds
MH  - Radionuclide Imaging
MH  - *Technetium
EDAT- 1987/10/01 00:00
MHDA- 1987/10/01 00:01
CRDT- 1987/10/01 00:00
PHST- 1987/10/01 00:00 [pubmed]
PHST- 1987/10/01 00:01 [medline]
PHST- 1987/10/01 00:00 [entrez]
AID - 10.1111/j.1445-5994.1987.tb00101.x [doi]
PST - ppublish
SO  - Aust N Z J Med. 1987 Oct;17(5):480-4. doi: 10.1111/j.1445-5994.1987.tb00101.x.