PMID- 34462555 OWN - NLM STAT- MEDLINE DCOM- 20220412 LR - 20230205 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 76 IP - 4 DP - 2022 Apr TI - Prevalence of hyperhomocysteinemia (HHcy) and its major determinants among hypertensive patients over 35 years of age. PG - 616-623 LID - 10.1038/s41430-021-00983-6 [doi] AB - OBJECTIVE: Hyperhomocysteinemia (HHcy) and hypertension are associated with cardiovascular events. However, effects of Hcy-lowing interventions on cardiovascular outcome were conflicting. Serum folate level was proposed to be a possible determinant of efficacy of extra folate supplementation on cardiovascular outcome. The aims of the present study were to describe representative information on the levels of serum homocysteine and folate in hypertensive patients, and to explore the major determinants of HHcy. METHODS: 11,007 participants with hypertension were analyzed in this cross-sectional study. Blood pressure and serum levels of biochemical indicators were measured. Multivariate logistic regression model was used to assess the associated factors of HHcy. RESULTS: Geometric mean of serum total homocysteine was 14.1 (95% CI: 13.9, 14.4) mumol/L and prevalence of HHcy was 36.1 (95% CI: 34.0, 38.1) % in hypertensive patients. HHcy was strongly associated with factors including male sex, older age, elevated serum creatinine (SCr), lower serum folate and vitamin B12, and uncontrolled blood pressure in hypertensive patients. Elevated SCr attributed to HHcy with the etiologic fraction of 0.29. The change of the odds ratio of HHcy associated with folate was significantly higher in patients with elevated SCr compared with that of patients with normal SCr. CONCLUSION: The results suggested the protection of female sex and higher levels of folate and vitamin B12 from HHcy and attribution of older age and elevated SCr to HHcy. Restoring renal function deserved attention for hypertensive patients to benefit from Hcy-lowing measures. CI - (c) 2021. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Cheng, Minna AU - Cheng M AUID- ORCID: 0000-0002-1270-6153 AD - Division of Chronic Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. chengminna@scdc.sh.cn. FAU - Xue, Hong AU - Xue H AD - Shanghai Key Laboratory of Bioactive Small Molecules and Shanghai Key Laboratory of Clinical Geriatric Medicine, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China. FAU - Li, Xinjian AU - Li X AD - Division of Chronic Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. FAU - Yan, Qinghua AU - Yan Q AD - Division of Chronic Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. FAU - Zhu, Dingliang AU - Zhu D AD - Research Center for Hypertension Management and Prevention in Community, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Wang, Yan AU - Wang Y AD - Research Center for Hypertension Management and Prevention in Community, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Shi, Yan AU - Shi Y AD - Division of Chronic Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. shiyan@scdc.sh.cn. AD - National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. shiyan@scdc.sh.cn. FAU - Fu, Chen AU - Fu C AD - Division of Chronic Non-communicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. fuchen@scdc.sh.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210830 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 RN - 0LVT1QZ0BA (Homocysteine) RN - 935E97BOY8 (Folic Acid) RN - P6YC3EG204 (Vitamin B 12) SB - IM MH - Cross-Sectional Studies MH - Female MH - Folic Acid MH - Homocysteine MH - Humans MH - *Hyperhomocysteinemia/complications/epidemiology MH - *Hypertension/epidemiology MH - Male MH - Prevalence MH - Risk Factors MH - Vitamin B 12 EDAT- 2021/09/01 06:00 MHDA- 2022/04/13 06:00 CRDT- 2021/08/31 06:33 PHST- 2020/07/18 00:00 [received] PHST- 2021/07/06 00:00 [accepted] PHST- 2021/06/21 00:00 [revised] PHST- 2021/09/01 06:00 [pubmed] PHST- 2022/04/13 06:00 [medline] PHST- 2021/08/31 06:33 [entrez] AID - 10.1038/s41430-021-00983-6 [pii] AID - 10.1038/s41430-021-00983-6 [doi] PST - ppublish SO - Eur J Clin Nutr. 2022 Apr;76(4):616-623. doi: 10.1038/s41430-021-00983-6. Epub 2021 Aug 30.