PMID- 34462936 OWN - NLM STAT- MEDLINE DCOM- 20220215 LR - 20220215 IS - 1099-1263 (Electronic) IS - 0260-437X (Linking) VI - 42 IP - 2 DP - 2022 Feb TI - The effects of thirdhand smoke on reproductive health. PG - 172-179 LID - 10.1002/jat.4227 [doi] AB - Tobacco smoke is an environmental pollutant that can cause follicle destruction and oocyte dysfunction. Thirdhand smoke (THS) is residual tobacco smoke existing in the environment long after cigarettes have been extinguished, which can react with other environmental compounds to produce secondary pollutants. THS contains a variety of toxic and harmful chemicals, such as nicotine and 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA), a logical biomarker of THS exposure. The health hazards of THS exposure and its components have been researched in recent years. In this review, we have summarized research progress on the effects of THS exposure on organs in mice and humans especially on the reproductive system. This review may help evaluate the health risks of THS, in particular reproduction and offspring health. We hope this review will guide public health education on the dangers of THS exposure and promotion of healthy living habits. CI - (c) 2021 John Wiley & Sons, Ltd. FAU - Liu, Huage AU - Liu H AUID- ORCID: 0000-0002-0813-4869 AD - Institute of Reproductive Medicine, Nantong University, Nantong, China. FAU - Chen, Hao AU - Chen H AD - Institute of Reproductive Medicine, Nantong University, Nantong, China. LA - eng PT - Journal Article PT - Review DEP - 20210830 PL - England TA - J Appl Toxicol JT - Journal of applied toxicology : JAT JID - 8109495 RN - 0 (Air Pollutants) RN - 0 (Tobacco Smoke Pollution) SB - IM MH - Air Pollutants/*toxicity MH - Animals MH - Female MH - Humans MH - Male MH - Mice MH - Rats MH - Reproduction/*drug effects MH - *Reproductive Health MH - Tobacco Smoke Pollution/*adverse effects OTO - NOTNLM OT - NNA OT - offspring OT - organ OT - reproduction OT - thirdhand smoke EDAT- 2021/09/01 06:00 MHDA- 2022/02/16 06:00 CRDT- 2021/08/31 06:49 PHST- 2021/07/26 00:00 [revised] PHST- 2021/07/01 00:00 [received] PHST- 2021/07/28 00:00 [accepted] PHST- 2021/09/01 06:00 [pubmed] PHST- 2022/02/16 06:00 [medline] PHST- 2021/08/31 06:49 [entrez] AID - 10.1002/jat.4227 [doi] PST - ppublish SO - J Appl Toxicol. 2022 Feb;42(2):172-179. doi: 10.1002/jat.4227. Epub 2021 Aug 30.