PMID- 34462972
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 35
IP  - 10
DP  - 2021 Oct
TI  - HPV infections in retinoblastoma: a systematic review.
PG  - e23981
LID - 10.1002/jcla.23981 [doi]
LID - e23981
AB  - BACKGROUND: Retinoblastoma is the most common primary intraocular malignancy in 
      children less than 4 years. Retinoblastoma (RB) contains about 3%-5% of all 
      childhood cancers. Recent studies demonstrated that interacting between RB tumor 
      suppressor and oncoproteins of DNA tumor viruses such as human papillomavirus 
      (HPV). The objective of the current systematic review study was to present 
      conducted studies in the field of HPV infection and its possible role in 
      retinoblastoma. METHODS: For this systematic review, all relevant original 
      research studies were assessed by searching in electronic databases include 
      PubMed, Embase, Scopus, Google Scholar, and Web of Science by using relevant 
      keywords. The study was designed based on the PRISMA criteria. All publications 
      with English literature and original researches are considered for screening. 
      RESULTS: Conducted search results lead to 4070 studies. The title and abstract 
      screening lead to 11 studies. Data extraction was performed on 8 included 
      studies. The prevalence of the HPV was ranged from 0 to 69%, and HPV genotype 16 
      and 18 were the most detected types. The most used method for the detection of 
      the viruses was PCR, and the most assessed sample was formalin-fixed, 
      paraffin-embedded tissue blocks. CONCLUSION: The association between HPV and 
      retinoblastoma is still inconsistent. The prevalence of the HPV in RB was ranged 
      from 0 to 69%, which indicates a wide range and highlights the importance of 
      further investigation for more accurate statistical of HPV prevalence in RB. 
      Thus, further worldwide studies of larger sample sizes of cohorts should be 
      investigated to clarify this uncertainty.
CI  - (c) 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Soltani, Saber
AU  - Soltani S
AUID- ORCID: 0000-0003-3369-0856
AD  - Department of Virology, School of Public Health, Tehran University of Medical 
      Sciences, Tehran, Iran.
AD  - Research Center for Clinical Virology, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Tabibzadeh, Alireza
AU  - Tabibzadeh A
AD  - Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Yousefi, Parastoo
AU  - Yousefi P
AD  - Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Zandi, Milad
AU  - Zandi M
AD  - Department of Virology, School of Public Health, Tehran University of Medical 
      Sciences, Tehran, Iran.
AD  - Research Center for Clinical Virology, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Zakeri, Armin
AU  - Zakeri A
AD  - Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran.
FAU - Akhavan Rezayat, Sara
AU  - Akhavan Rezayat S
AD  - Department of Management & Health Economics, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Ramezani, Akam
AU  - Ramezani A
AD  - Research Center for Clinical Virology, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Esghaei, Maryam
AU  - Esghaei M
AD  - Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Farahani, Abbas
AU  - Farahani A
AUID- ORCID: 0000-0002-0245-2612
AD  - Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, 
      Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
LA  - eng
GR  - 4000271/Hormozgan University of Medical Sciences/
PT  - Journal Article
PT  - Systematic Review
DEP - 20210830
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
SB  - IM
MH  - Human papillomavirus 16
MH  - Human papillomavirus 18
MH  - Humans
MH  - *Papillomavirus Infections/complications/epidemiology
MH  - Prevalence
MH  - *Retinal Neoplasms/complications/epidemiology
MH  - *Retinoblastoma/epidemiology/virology
PMC - PMC8529131
OTO - NOTNLM
OT  - human papillomavirus
OT  - human papillomavirus 16
OT  - human papillomavirus 18
OT  - retinoblastoma
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/09/01 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/08/30
CRDT- 2021/08/31 06:52
PHST- 2021/08/15 00:00 [revised]
PHST- 2021/07/15 00:00 [received]
PHST- 2021/08/17 00:00 [accepted]
PHST- 2021/09/01 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/08/31 06:52 [entrez]
PHST- 2021/08/30 00:00 [pmc-release]
AID - JCLA23981 [pii]
AID - 10.1002/jcla.23981 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2021 Oct;35(10):e23981. doi: 10.1002/jcla.23981. Epub 2021 Aug 
      30.