PMID- 34466009
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220426
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - Association Between Chinese Visceral Adiposity Index and Incident Type 2 Diabetes 
      Mellitus in Japanese Adults.
PG  - 3743-3751
LID - 10.2147/DMSO.S322935 [doi]
AB  - BACKGROUND: Obesity is a well-known risk factor for type 2 diabetes mellitus 
      (T2DM). Studies have shown that the Chinese visceral adiposity index (CVAI), a 
      novel visceral adiposity indicator, is positive associated with the risk of T2DM 
      in the Chinese population. This study aimed to investigate the correlation 
      between CVAI and incident T2DM in a Japanese population. METHODS: We performed a 
      secondary analysis of open-access data from a retrospective cohort study. This 
      study included 15,464 participants who received regular medical examinations at 
      Murakami Memorial Hospital. All participants underwent a questionnaire survey, 
      physical examination, and blood biochemical testing at baseline. The main outcome 
      was new-onset T2DM during follow-up. Cox regression analysis and Kaplan-Meier 
      analysis were used to analyze the risk of CVAI on T2DM, and we conducted smooth 
      curve fitting. Receiver operating characteristic (ROC) curve analysis was 
      performed to assess the predictive value of CVAI, body mass index (BMI), and 
      waist circumference (WC) for incident T2DM. RESULTS: During a median follow-up 
      time of 5.39 years, 373 new-onset T2DM events were observed. Kaplan-Meier curves 
      showed that the incidence of T2DM increased as the CVAI increased (log-rank chi (2) 
      = 187.1076 and 129.6067 in males and females, respectively, both P <0.001). After 
      adjustment for covariates, per 1 increase of CVAI was associated with a 
      1.0133-fold and 1.0246-fold higher risk of incident T2DM in males and females, 
      respectively (both P <0.001). Those individuals in the top CVAI quartile group 
      had the highest risk of new-onset T2DM (HR = 3.1568 and 5.8415 in males and 
      females, respectively, both P <0.05). A nonlinear relationship was identified by 
      the smooth fitting curve between CVAI and T2DM events in both genders. ROC 
      analysis indicated that CVAI had better predictive power than BMI and WC in both 
      genders. CONCLUSION: Our results demonstrate that CVAI was significantly 
      associated with an increased risk of new-onset T2DM in Japanese adults.
CI  - (c) 2021 Shang et al.
FAU - Shang, Luxiang
AU  - Shang L
AUID- ORCID: 0000-0002-7496-4246
AD  - Department of Cardiology, The First Affiliated Hospital of Shandong First Medical 
      University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and 
      Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, 
      Shandong, People's Republic of China.
FAU - Li, Rui
AU  - Li R
AD  - Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, 
      People's Republic of China.
FAU - Zhao, Yang
AU  - Zhao Y
AD  - Department of Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac 
      Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang, People's Republic of China.
FAU - Sun, Huaxin
AU  - Sun H
AD  - Department of Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac 
      Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang, People's Republic of China.
FAU - Tang, Baopeng
AU  - Tang B
AD  - Department of Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac 
      Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang, People's Republic of China.
FAU - Hou, Yinglong
AU  - Hou Y
AD  - Department of Cardiology, The First Affiliated Hospital of Shandong First Medical 
      University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and 
      Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, 
      Shandong, People's Republic of China.
LA  - eng
SI  - Dryad/10.5061/dryad.8q0p192
PT  - Journal Article
DEP - 20210824
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8402978
OTO - NOTNLM
OT  - Chinese visceral adiposity index
OT  - Japanese adults
OT  - cohort study
OT  - diabetes mellitus
OT  - obesity
OT  - type 2 diabetes mellitus
COIS- All authors report no conflicts of interest related to this manuscript.
EDAT- 2021/09/02 06:00
MHDA- 2021/09/02 06:01
PMCR- 2021/08/24
CRDT- 2021/09/01 07:21
PHST- 2021/06/01 00:00 [received]
PHST- 2021/08/03 00:00 [accepted]
PHST- 2021/09/01 07:21 [entrez]
PHST- 2021/09/02 06:00 [pubmed]
PHST- 2021/09/02 06:01 [medline]
PHST- 2021/08/24 00:00 [pmc-release]
AID - 322935 [pii]
AID - 10.2147/DMSO.S322935 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Aug 24;14:3743-3751. doi: 10.2147/DMSO.S322935. 
      eCollection 2021.