PMID- 34466350
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210903
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 9
IP  - 9
DP  - 2021 Sep
TI  - The mucin phenotype does not affect the endoscopic resection outcome of 
      non-ampullary duodenal epithelial tumors.
PG  - E1297-E1302
LID - 10.1055/a-1477-3186 [doi]
AB  - Background and study aims  Some studies have reported an association between 
      clinicopathological features and mucin phenotypes of non-ampullary duodenal 
      epithelial tumors (NADETs). However, the association between clinical outcomes of 
      endoscopic resection (ER) and mucin phenotypes has not been elucidated. The aim 
      of this retrospective study was to analyze clinical outcomes of ER of NADETs with 
      reference to mucin phenotypes. Patients and methods  We retrospectively evaluated 
      the clinical outcomes of ER for NADETs performed from 2006 to 2019 and compared 
      clinicopathological characteristics, ER procedures, and outcomes, including 
      adverse events (AEs) among tumors classified by mucin phenotype. Mucin phenotypes 
      were classified as gastric, gastrointestinal, and intestinal based on 
      immunohistochemical examination. Grade of dysplasia was determined according to 
      the Vienna classification (VCL). Results  The proportion of VCL 4/5 was higher in 
      the gastric type (50 %) compared with that in the gastrointestinal (39.1 %, P 
       = 0.009) and intestinal types (5.4 %, P  = 0.008), respectively. With no 
      statistical difference in tumor size and ER method among the three groups, no 
      significant difference was observed for ER outcomes, i. e., en bloc and R0 
      resection rates. In the gastrointestinal and intestinal types, AEs occurred in 
      four cases treated with ESD, but none developed in the gastric type. Conclusions  
      This study suggests that the mucin phenotype does not affect resection outcome. 
      However, considering high malignant potential and tendency for low AE rates, the 
      gastric type NADETs may be more appropriate for proactive ER than the others.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commercial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Toya, Yosuke
AU  - Toya Y
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Endo, Masaki
AU  - Endo M
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
AD  - Kaiunbashi Endoscopy Clinic, Morioka, Japan.
FAU - Yamada, Shun
AU  - Yamada S
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Oizumi, Tomofumi
AU  - Oizumi T
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Morishita, Toshifumi
AU  - Morishita T
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Akasaka, Risaburo
AU  - Akasaka R
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Yanai, Shunichi
AU  - Yanai S
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Nakamura, Shotaro
AU  - Nakamura S
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Eizuka, Makoto
AU  - Eizuka M
AD  - Division of Molecular Diagnostic Pathology, Department of Pathology, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Uesugi, Noriyuki
AU  - Uesugi N
AD  - Division of Molecular Diagnostic Pathology, Department of Pathology, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Sugai, Tamotsu
AU  - Sugai T
AD  - Division of Molecular Diagnostic Pathology, Department of Pathology, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
FAU - Matsumoto, Takayuki
AU  - Matsumoto T
AD  - Division of Gastroenterology, Department of Internal Medicine, School of 
      Medicine, Iwate Medical University, Yahaba, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210816
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC8367432
COIS- Competing interests The authors declare that they have no conflict of interest.
EDAT- 2021/09/02 06:00
MHDA- 2021/09/02 06:01
PMCR- 2021/08/01
CRDT- 2021/09/01 07:24
PHST- 2020/12/22 00:00 [received]
PHST- 2021/03/08 00:00 [accepted]
PHST- 2021/09/01 07:24 [entrez]
PHST- 2021/09/02 06:00 [pubmed]
PHST- 2021/09/02 06:01 [medline]
PHST- 2021/08/01 00:00 [pmc-release]
AID - 10.1055/a-1477-3186 [doi]
PST - epublish
SO  - Endosc Int Open. 2021 Aug 16;9(9):E1297-E1302. doi: 10.1055/a-1477-3186. 
      eCollection 2021 Sep.