PMID- 34467577
OWN - NLM
STAT- MEDLINE
DCOM- 20211224
LR  - 20221207
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 35
IP  - 12
DP  - 2021 Dec
TI  - The effect of Gymnema sylvestre supplementation on glycemic control in type 2 
      diabetes patients: A systematic review and meta-analysis.
PG  - 6802-6812
LID - 10.1002/ptr.7265 [doi]
AB  - This systematic review and meta-analysis aims to find the effect of Gymnema 
      sylvestre (GS) supplementation on glycemic control in type-2 diabetes mellitus 
      (T2DM). PubMed, Cochrane library, Google Scholar, and Science Direct were 
      searched from inception to June 2020 to identify the studies that reported GS 
      supplementation on glycemic parameters. Standardized mean difference (SMD) was 
      calculated by comparing the post-intervention data with baseline data. SMDs with 
      95% confidence intervals (CIs) were pooled using a random-effects model. Our 
      meta-analysis consisting of 10 studies with a total of 419 participants showed 
      that GS supplementation significantly reduces fasting blood glucose (FBG) (SMD 
      1.57 mg/dl, 95% CI 2.22 to -0.93, p < .0001, I(2) 90%), postprandial blood 
      glucose (PPBG) (SMD 1.04 mg/dl, 95% CI 1.53 to -0.54, p < .0001, I(2) 80%), and 
      glycated haemoglobin (HbA1c) (SMD 3.91, 95% CI 7.35 to -0.16%, p < .0001, I(2) 
      99%) compared to baseline. Further, our study also found that GS significantly 
      reduces triglycerides (SMD 1.81 mg/dl, 95% CI 2.95 to -0.66, p < .0001, I(2) : 
      96%), and total cholesterol (SMD 4.10 mg/dl, 95% CI 7.21 to -0.99, p < .0001, 
      I(2) : 98%) compared to baseline. Our study shows that GS supplementation is 
      effective in improving glycemic control and reducing lipid levels in T2DM 
      patients and suggests that such supplementation might be used as an effective 
      therapy for the management of T2DM and its associated complications to an extent.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Devangan, Suneel
AU  - Devangan S
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research-Guwahati, Guwahati, Assam, India.
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research-Hajipur, Hajipur, Bihar, India.
FAU - Varghese, Bincy
AU  - Varghese B
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research-Guwahati, Guwahati, Assam, India.
FAU - Johny, Ebin
AU  - Johny E
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research-Guwahati, Guwahati, Assam, India.
FAU - Gurram, Surender
AU  - Gurram S
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research-Guwahati, Guwahati, Assam, India.
FAU - Adela, Ramu
AU  - Adela R
AUID- ORCID: 0000-0003-0909-2557
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research-Guwahati, Guwahati, Assam, India.
LA  - eng
GR  - Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, Govt. 
      of India/
GR  - NIPER-Guwahati/
GR  - Institutional Core Grant/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20210901
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Dietary Supplements
MH  - Glycated Hemoglobin/analysis
MH  - Glycemic Control
MH  - *Gymnema sylvestre
MH  - Humans
OTO - NOTNLM
OT  - Gymnema sylvestre
OT  - glycemic control
OT  - lipid profile
OT  - meta-analysis
OT  - systematic review
OT  - type-2 DM
EDAT- 2021/09/02 06:00
MHDA- 2021/12/25 06:00
CRDT- 2021/09/01 07:43
PHST- 2021/06/15 00:00 [revised]
PHST- 2021/04/02 00:00 [received]
PHST- 2021/08/14 00:00 [accepted]
PHST- 2021/09/02 06:00 [pubmed]
PHST- 2021/12/25 06:00 [medline]
PHST- 2021/09/01 07:43 [entrez]
AID - 10.1002/ptr.7265 [doi]
PST - ppublish
SO  - Phytother Res. 2021 Dec;35(12):6802-6812. doi: 10.1002/ptr.7265. Epub 2021 Sep 1.