PMID- 34470170
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210903
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 282
DP  - 2021 Nov
TI  - Toxicity of amine-functionalized single-carbon nanotube (NH(2) f-SWCNT) to 
      Channel Catfish (Ietalurus Punetaus): Organ pathologies, oxidative stress, 
      inflammation, and apoptosis.
PG  - 131133
LID - S0045-6535(21)01605-2 [pii]
LID - 10.1016/j.chemosphere.2021.131133 [doi]
AB  - The rapid development of carbon nanotubes (CNTs) in the field of fish disease 
      control and prevention raises concerns about the toxicity and safe use in fish. 
      This study was performed to assess the effect on histological changes, oxidative 
      stress related markers in response to various concentrations of 
      amine-functionalized single carbon nanotubes (NH(2) f-SWCNT) (1, 10 and 
      100 mg kg(-1) fish) in Channel Catfish (Ietalurus Punetaus) for up to 10 days. 
      Moreover, pro-inflammatory cytokine genes and apoptotic genes were analyzed to 
      obtain a better understanding of molecular mechanism of NH(2) f-SWCNT induced 
      toxicity. As a result, intraperitoneal (i.p.) administration of NH(2) f-SWCNT 
      caused dose-dependent and time-dependent injuries in the sampled tissues. In 
      comparison with the control groups, decrease of catalase (CAT) activity and 
      superoxide dismutase (SOD), and increase of malondialdehyde (MDA) and lactin 
      dehydrogenase (LDH) were observed in all treatments. Real-time PCR assay showed 
      inflammatory response with dose-dependent increase of tumor necrosis factor alpha 
      (TNFalpha) and transient increase of interleukin 1beta (IL-1beta) in the liver. NH(2) 
      f-SWCNT administration induced increase of p38 as well as caspase-3 in all 
      treatments compared to the control groups, indicating the involvement of p38-MAPK 
      cascade and caspase-3 cascade in liver cell apoptosis. Overall, we conclude that 
      NH(2) f-SWCNT exert effects by direct injury and indirectly oxidative stress, 
      resulting in inflammation and apoptosis, which provides data for understanding of 
      the biological mechanisms underlying the toxicity of CNTs in fish.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Gao, Xiaochan
AU  - Gao X
AD  - School of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471003, China. Electronic address: gaoxiaochansx@163.com.
FAU - Zheng, Xudong
AU  - Zheng X
AD  - School of Physics and Engineering, Henan University of Science and Technology, 
      Luoyang, 471003, China. Electronic address: xd_zheng88@163.com.
FAU - Gao, Shiyang
AU  - Gao S
AD  - School of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471003, China. Electronic address: gaoshiyanggsy@163.com.
FAU - Huang, Yong
AU  - Huang Y
AD  - School of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471003, China. Electronic address: huangyong1979111@126.com.
FAU - Xiong, Jianli
AU  - Xiong J
AD  - School of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471003, China. Electronic address: xjlpanda@126.com.
FAU - Ren, Hongtao
AU  - Ren H
AD  - School of Animal Science and Technology, Henan University of Science and 
      Technology, Luoyang, 471003, China. Electronic address: hthn2012@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210607
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Amines)
RN  - 0 (Nanotubes, Carbon)
SB  - IM
MH  - Amines
MH  - Animals
MH  - Apoptosis
MH  - *Ictaluridae
MH  - Inflammation/chemically induced
MH  - *Nanotubes, Carbon/toxicity
MH  - Oxidative Stress
OTO - NOTNLM
OT  - Carbon nanotube
OT  - Fish
OT  - Intraperitoneal administration
OT  - Nanotoxicology
OT  - Pro-inflammatory cytokines
EDAT- 2021/09/03 06:00
MHDA- 2021/09/04 06:00
CRDT- 2021/09/02 01:01
PHST- 2021/03/10 00:00 [received]
PHST- 2021/06/03 00:00 [revised]
PHST- 2021/06/03 00:00 [accepted]
PHST- 2021/09/02 01:01 [entrez]
PHST- 2021/09/03 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
AID - S0045-6535(21)01605-2 [pii]
AID - 10.1016/j.chemosphere.2021.131133 [doi]
PST - ppublish
SO  - Chemosphere. 2021 Nov;282:131133. doi: 10.1016/j.chemosphere.2021.131133. Epub 
      2021 Jun 7.