PMID- 34470175
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210903
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 282
DP  - 2021 Nov
TI  - Associations of multiple metals with bone mineral density: A population-based 
      study in US adults.
PG  - 131150
LID - S0045-6535(21)01622-2 [pii]
LID - 10.1016/j.chemosphere.2021.131150 [doi]
AB  - Epidemiologic studies focus on combined effects of multiple metals on bone 
      mineral density (BMD) are scarce. Therefore, this study was conducted to examine 
      associations of multiple metals exposure with BMD. Data of adults aged >/=20 years 
      (n = 2545) from the US National Health and Nutrition Examination Survey (NHANES, 
      2011-2016) were collected and analyzed. Concentrations of metals were measured in 
      blood (cadmium [Cd], lead [Pb], mercury [Hg], and manganese [Mn]) and serum 
      (copper [Cu], selenium [Se], and zinc [Zn]) using inductively coupled plasma mass 
      spectrometry and inductively coupled plasma dynamic reaction cell mass 
      spectrometry, respectively. The weighted quantile sum (WQS) and Bayesian kernel 
      machine regression (BKMR) models were performed to determine the joint effects of 
      multiple metals exposure on lumbar and total BMD. The linear regression analyses 
      showed Pb was negatively associated with BMDs. The WQS regression analyses 
      revealed that the WQS index was inversely related to lumbar (beta = -0.022, 95% CI: 
      -0.036, -0.008) and total BMD (beta = -0.015, 95% CI: -0.024, -0.006), and Se, Mn, 
      and Pb were the main contributors for the combined effects. Additionally, 
      nonlinear dose-response relationships between Pb, Mn, and Se and BMD, as well as 
      a synergistic interaction of Pb and Mn, were found in the BKMR analyses. Our 
      findings suggested co-exposure to Cd, Pb, Hg, Mn, Cu, Se, and Zn (above their 
      50th percentiles) was associated with reduced BMD, and Pb, Mn, and Se were the 
      main contributors driving the overall effects.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Wei, Mu-Hong
AU  - Wei MH
AD  - MOE Key Lab of Environment and Health, Department of Epidemiology and 
      Biostatistics, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Cui, Yuan
AU  - Cui Y
AD  - MOE Key Lab of Environment and Health, Department of Epidemiology and 
      Biostatistics, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Zhou, Hao-Long
AU  - Zhou HL
AD  - MOE Key Lab of Environment and Health, Department of Epidemiology and 
      Biostatistics, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Song, Wen-Jing
AU  - Song WJ
AD  - MOE Key Lab of Environment and Health, Department of Epidemiology and 
      Biostatistics, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Di, Dong-Sheng
AU  - Di DS
AD  - MOE Key Lab of Environment and Health, Department of Epidemiology and 
      Biostatistics, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Zhang, Ru-Yi
AU  - Zhang RY
AD  - MOE Key Lab of Environment and Health, Department of Epidemiology and 
      Biostatistics, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Huang, Qin
AU  - Huang Q
AD  - Department of Rehabilitation Medicine, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430030, China.
FAU - Liu, Jun-An
AU  - Liu JA
AD  - Department of Social Medicine and Health Management, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430030, China. Electronic address: lja10_11@163.com.
FAU - Wang, Qi
AU  - Wang Q
AD  - MOE Key Lab of Environment and Health, Department of Epidemiology and 
      Biostatistics, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China. Electronic address: 
      wangqi_tj@hust.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210611
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Metals)
RN  - 00BH33GNGH (Cadmium)
SB  - IM
MH  - Bayes Theorem
MH  - *Bone Density
MH  - Cadmium
MH  - *Metals
MH  - Nutrition Surveys
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Bone mineral density
OT  - Joint effect
OT  - Multiple metals
OT  - Weighted quantile sum regression
EDAT- 2021/09/03 06:00
MHDA- 2021/09/04 06:00
CRDT- 2021/09/02 01:01
PHST- 2021/03/22 00:00 [received]
PHST- 2021/06/06 00:00 [revised]
PHST- 2021/06/08 00:00 [accepted]
PHST- 2021/09/02 01:01 [entrez]
PHST- 2021/09/03 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
AID - S0045-6535(21)01622-2 [pii]
AID - 10.1016/j.chemosphere.2021.131150 [doi]
PST - ppublish
SO  - Chemosphere. 2021 Nov;282:131150. doi: 10.1016/j.chemosphere.2021.131150. Epub 
      2021 Jun 11.