PMID- 34470791
OWN - NLM
STAT- MEDLINE
DCOM- 20220502
LR  - 20220502
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 49
IP  - 3
DP  - 2022 Mar
TI  - Performance of 3 Composite Measures for Disease Activity in Peripheral 
      Spondyloarthritis.
PG  - 256-264
LID - 10.3899/jrheum.210075 [doi]
AB  - OBJECTIVE: To investigate concurrent validity and discrimination of the Disease 
      Activity Index for Psoriatic Arthritis (DAPSA) score, Psoriatic Arthritis Disease 
      Activity Score (PASDAS), and Ankylosing Spondylitis Disease Activity Score 
      (ASDAS) in peripheral spondyloarthritis (pSpA) in clinical practice. METHODS: 
      Data from a Dutch registry for SpA (SpA-Net) were used. Predefined hypotheses on 
      concurrent validity of the composite measures with 15 other outcome measures of 
      disease activity, physical function, and health-related quality of life were 
      tested. Concurrent validity was considered acceptable if >/= 75% of the hypotheses 
      were confirmed. Discrimination was assessed by stratifying patients in DAPSA, 
      PASDAS, and ASDAS predefined disease activity states and studying mean 
      differences in health outcomes by 1-way ANOVA. Further, the concordance in 
      disease activity states was determined. All analyses were repeated in subgroups 
      with and without psoriasis (PsO). RESULTS: DAPSA, PASDAS, and ASDAS scores were 
      available for 191, 139, and 279 patients with pSpA, respectively. The concurrent 
      validity and discrimination of all composite measures were acceptable, as the 
      strength of correlations were as hypothesized in >/= 75% of the studied 
      correlations. With increasing disease activity states, scores in nearly all 
      outcome measures worsened significantly. The DAPSA, PASDAS, and ASDAS classified 
      22%, 56%, and 48% of the patients, respectively, in the 2 highest disease 
      activity states. Stratified analyses for concomitant PsO revealed no relevant 
      subgroup differences. CONCLUSION: The performance of DAPSA, PASDAS, and ASDAS in 
      pSpA was acceptable, and independent of concomitant PsO. Due to discrepancy in 
      classification, the validity of existing thresholds for disease activity states 
      warrants further study in pSpA.
CI  - Copyright (c) 2022 by the Journal of Rheumatology.
FAU - Beckers, Esther
AU  - Beckers E
AUID- ORCID: 0000-0003-1098-8908
AD  - E. Beckers, MSc, M. Been, MD, C. Webers, MD, PhD, A. Boonen, MD, PhD, Professor, 
      A. van Tubergen, MD, PhD, Professor, Department of Internal Medicine, Division of 
      Rheumatology, Maastricht University Medical Center, and Care and Public Health 
      Research Institute (CAPHRI), Maastricht University, Maastricht; 
      esther.beckers@mumc.nl.
FAU - Been, Marin
AU  - Been M
AUID- ORCID: 0000-0002-0603-1102
AD  - E. Beckers, MSc, M. Been, MD, C. Webers, MD, PhD, A. Boonen, MD, PhD, Professor, 
      A. van Tubergen, MD, PhD, Professor, Department of Internal Medicine, Division of 
      Rheumatology, Maastricht University Medical Center, and Care and Public Health 
      Research Institute (CAPHRI), Maastricht University, Maastricht.
FAU - Webers, Casper
AU  - Webers C
AUID- ORCID: 0000-0003-3011-8547
AD  - E. Beckers, MSc, M. Been, MD, C. Webers, MD, PhD, A. Boonen, MD, PhD, Professor, 
      A. van Tubergen, MD, PhD, Professor, Department of Internal Medicine, Division of 
      Rheumatology, Maastricht University Medical Center, and Care and Public Health 
      Research Institute (CAPHRI), Maastricht University, Maastricht.
FAU - Boonen, Annelies
AU  - Boonen A
AD  - E. Beckers, MSc, M. Been, MD, C. Webers, MD, PhD, A. Boonen, MD, PhD, Professor, 
      A. van Tubergen, MD, PhD, Professor, Department of Internal Medicine, Division of 
      Rheumatology, Maastricht University Medical Center, and Care and Public Health 
      Research Institute (CAPHRI), Maastricht University, Maastricht.
FAU - Ten Klooster, Peter M
AU  - Ten Klooster PM
AUID- ORCID: 0000-0002-2565-5439
AD  - P.M. ten Klooster, PhD, Department of Psychology, Health & Technology, University 
      of Twente, Enschede.
FAU - Vonkeman, Harald E
AU  - Vonkeman HE
AUID- ORCID: 0000-0003-3792-7718
AD  - H.E. Vonkeman, MD, PhD, Department of Psychology, Health & Technology, University 
      of Twente, Enschede, and Department of Rheumatology, Medisch Spectrum Twente, 
      Enschede, the Netherlands.
FAU - van Tubergen, Astrid
AU  - van Tubergen A
AUID- ORCID: 0000-0001-8477-0683
AD  - E. Beckers, MSc, M. Been, MD, C. Webers, MD, PhD, A. Boonen, MD, PhD, Professor, 
      A. van Tubergen, MD, PhD, Professor, Department of Internal Medicine, Division of 
      Rheumatology, Maastricht University Medical Center, and Care and Public Health 
      Research Institute (CAPHRI), Maastricht University, Maastricht.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210901
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
SB  - IM
MH  - *Arthritis, Psoriatic/diagnosis
MH  - Humans
MH  - Outcome Assessment, Health Care
MH  - Quality of Life
MH  - Severity of Illness Index
MH  - *Spondylitis, Ankylosing
OTO - NOTNLM
OT  - disease activity score
OT  - outcome assessment
OT  - psoriatic arthritis
OT  - spondyloarthropathy
EDAT- 2021/09/03 06:00
MHDA- 2022/05/03 06:00
CRDT- 2021/09/02 06:00
PHST- 2021/08/13 00:00 [accepted]
PHST- 2021/09/03 06:00 [pubmed]
PHST- 2022/05/03 06:00 [medline]
PHST- 2021/09/02 06:00 [entrez]
AID - jrheum.210075 [pii]
AID - 10.3899/jrheum.210075 [doi]
PST - ppublish
SO  - J Rheumatol. 2022 Mar;49(3):256-264. doi: 10.3899/jrheum.210075. Epub 2021 Sep 1.