PMID- 34470995
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210903
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 67
IP  - 4
DP  - 2021
TI  - Association between Serum Biotin Levels and Cedar Pollinosis in Japanese 
      Schoolchildren.
PG  - 211-216
LID - 10.3177/jnsv.67.211 [doi]
AB  - Biotin is a water-soluble B complex vitamin and coenzyme of five types of 
      carboxylase and plays crucial roles in fatty acid, glucose, and amino acid 
      metabolism. Nutritional biotin deficiency and defective enzymes essential for 
      biotin metabolism cause inflammatory diseases such as eczema-like dermatitis and 
      Crohn's disease; however, little is known about the pathophysiological roles of 
      biotin. This study investigated the relationship between biotin metabolism and 
      human allergic sensitization and diseases by measuring serum levels of biotin, 
      total immunoglobulin E (IgE) and allergen-specific IgEs in more than 400 Japanese 
      schoolchildren aged 6 to 12. The prevalence of allergic diseases, and 
      environmental and life-style factors were also examined by a questionnaire. Like 
      total IgE, serum biotin levels of children showed a log-normal distribution. 
      Meanwhile, Spearman's rank correlation analysis showed weak but significant 
      positive associations between serum biotin levels and total IgE (rho=0.147, 
      p=0.0029) as well as allergen-specific IgEs against egg whites (rho=0.215, 
      p=0.00013), cedar pollen (rho=0.176, p=0.00036), and cat dander (rho=0.130, 
      p=0.0085). Furthermore, mean serum biotin levels in children with cedar 
      pollinosis, but not with other allergic diseases such as asthma and allergic 
      rhinitis, were significantly higher than in those without (p=0.0015). These 
      results suggest a correlation between serum biotin levels and the development of 
      cedar pollinosis. Further prospective studies are needed to evaluate the causal 
      relationship between biotin metabolism and cedar pollen sensitization and 
      pollinosis development.
FAU - Sakurai-Yageta, Mika
AU  - Sakurai-Yageta M
AD  - Department of Education and Training, Tohoku Medical Megabank Organization, 
      Tohoku University.
FAU - Mashimo, Yoichi
AU  - Mashimo Y
AD  - Department of Public Health, Graduate School of Medicine, Chiba University.
FAU - Kuroishi, Toshinobu
AU  - Kuroishi T
AD  - Division of Oral Immunology, Tohoku University Graduate School of Dentistry, 
      Tohoku University.
FAU - Ishihara, Rino
AU  - Ishihara R
AD  - Department of Education and Training, Tohoku Medical Megabank Organization, 
      Tohoku University.
FAU - Shimojo, Naoki
AU  - Shimojo N
AD  - Department of Pediatrics, Graduate School of Medicine, Chiba University.
AD  - Center for Preventive Medical Sciences, Chiba University.
FAU - Kohno, Yoichi
AU  - Kohno Y
AD  - Department of Pediatrics, Graduate School of Medicine, Chiba University.
AD  - Chiba Rosai Hospital.
FAU - Okamoto, Yoshitaka
AU  - Okamoto Y
AD  - Chiba Rosai Hospital.
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of 
      Medicine, Chiba University.
FAU - Hata, Akira
AU  - Hata A
AD  - Department of Public Health, Graduate School of Medicine, Chiba University.
FAU - Suzuki, Yoichi
AU  - Suzuki Y
AD  - Department of Education and Training, Tohoku Medical Megabank Organization, 
      Tohoku University.
AD  - Department of Public Health, Graduate School of Medicine, Chiba University.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 6SO6U10H04 (Biotin)
SB  - IM
MH  - Allergens
MH  - Biotin
MH  - Child
MH  - Humans
MH  - Immunoglobulin E
MH  - Japan/epidemiology
MH  - Pollen
MH  - *Rhinitis, Allergic, Seasonal/epidemiology
OTO - NOTNLM
OT  - allergic diseases
OT  - allergic sensitization
OT  - cedar pollen-specific IgE
OT  - pediatric allergies
OT  - vitamin B7
EDAT- 2021/09/03 06:00
MHDA- 2021/09/04 06:00
CRDT- 2021/09/02 06:03
PHST- 2021/09/02 06:03 [entrez]
PHST- 2021/09/03 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
AID - 10.3177/jnsv.67.211 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2021;67(4):211-216. doi: 10.3177/jnsv.67.211.