PMID- 34471009
OWN - NLM
STAT- MEDLINE
DCOM- 20211231
LR  - 20211231
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 141
IP  - 9
DP  - 2021
TI  - [Design of Synthetic Polymer Nanoparticles That Capture and Neutralize Target 
      Molecules].
PG  - 1079-1086
LID - 10.1248/yakushi.21-00125 [doi]
AB  - Protein affinity reagents that specifically and strongly bind to target molecules 
      are widely used in disease detection, diagnosis, and therapy. Although antibodies 
      and their fragments are the gold standard in protein-protein inhibitors (PPIs), 
      synthetic polymers such as linear polymers, dendrimers, and nanoparticles as 
      cost-effective PPIs have attracted great attention as alternatives to antibodies. 
      These polymers exhibit high affinity to the target by imitating natural 
      protein-protein interactions. However, only a few in vivo applications have been 
      reported. Here, our recent advances in the development of synthetic polymers for 
      in vivo application are reviewed. Poly(N-isopropylacrylamide) (pNIPAm) was used 
      as a model of synthetic affinity reagents. Incorporation of both sulfated 
      carbohydrate and hydrophobic monomers into lightly crosslinked pNIPAm 
      nanoparticles (NPs) captured and neutralized vascular endothelial growth factor 
      (VEGF) and inhibited tumor growth upon intravenous injection into tumor-bearing 
      mice. Modification of a liposome with the pNIPAm-based linear polymer increased 
      the polymer circulation time after intravenous injection and improved the 
      affinity for the target. The pNIPAm-based NPs delivered by oral administration 
      captured the target small molecules and inhibited their absorption from the 
      intestine. Our recent findings provide useful information for the design of 
      synthetic polymers that capture target molecules in vivo.
FAU - Koide, Hiroyuki
AU  - Koide H
AD  - Department of Medical Biochemistry, School of Pharmaceutical Sciences, University 
      of Shizuoka.
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Acrylic Resins)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Liposomes)
RN  - 0 (Polymers)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 25189-55-3 (poly-N-isopropylacrylamide)
SB  - IM
MH  - *Acrylic Resins/administration & dosage/chemistry/metabolism/pharmacology
MH  - Administration, Oral
MH  - Animals
MH  - Drug Design/*methods
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Indicators and Reagents
MH  - Injections, Intravenous
MH  - Liposomes
MH  - Mice
MH  - Molecular Targeted Therapy/*methods
MH  - *Nanoparticles/chemistry
MH  - Neoplasms/drug therapy/pathology
MH  - *Polymers/administration & dosage/chemistry/metabolism/pharmacology
MH  - Vascular Endothelial Growth Factor A/administration & 
      dosage/metabolism/pharmacology
OTO - NOTNLM
OT  - linear polymer
OT  - lipid nanoparticle
OT  - molecular recognition
OT  - polymer nanoparticle
OT  - protein affinity reagent
EDAT- 2021/09/03 06:00
MHDA- 2022/01/01 06:00
CRDT- 2021/09/02 06:03
PHST- 2021/09/02 06:03 [entrez]
PHST- 2021/09/03 06:00 [pubmed]
PHST- 2022/01/01 06:00 [medline]
AID - 10.1248/yakushi.21-00125 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2021;141(9):1079-1086. doi: 10.1248/yakushi.21-00125.