PMID- 34474033 OWN - NLM STAT- MEDLINE DCOM- 20220107 LR - 20230308 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 204 IP - Pt A DP - 2022 Mar TI - Monitoring temporal trends of dioxins, organochlorine pesticides and chlorinated paraffins in pooled serum samples collected from Northern Norwegian women: The MISA cohort study. PG - 111980 LID - S0013-9351(21)01275-5 [pii] LID - 10.1016/j.envres.2021.111980 [doi] AB - The ubiquitous presence of legacy and emerging persistent organic pollutants (POPs) in the environmental matrices poses a potential hazard to the humans and creating public health concerns. The present study aimed to evaluate dioxins, dioxin-like polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and chlorinated paraffins (CPs) concentrations in serum of women (postpartum, pregnant and non-pregnant) from Northern Norway to better understand their exposure and contamination status as well as temporal trends across 2007-2009 (MISA 1) to 2019 (MISA 2). Sixty-two blood samples from the MISA 1 cohort and 38 samples from MISA 2 were randomly selected in this study (n = 100). Ninety samples from postpartum (MISA 1) and pregnant women (MISA 2) were randomly combined into 9 pools, with 9-11 individual samples contributing to each pool keeping the groups of pregnant and postpartum women. Remaining 10 samples from non-pregnant women (MISA 2) were allocated into separate group. Geometric mean, minimum and maximum were used to describe the serum concentrations of pooled POPs in MISA cohort. Mann-Whitney U test and independent sample t-test were applied for trend analysis of blood levels of POPs between MISA 1 and MISA 2. We found the serum concentrations of selected POPs in this study to be at lower range. Serum concentrations of dibenzo-p-dioxins (PCDDs) (p = 0.010), polychlorinated dibenzofurans (PCDFs) (p = 0.002), dioxins-like PCBs (p = 0.001), hexachlorobenzene (HCB) (p < 0.001) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) (p = 0.002) were decreased between the studied time. In contrast, the serum concentrations of medium chain chlorinated paraffins showed an increasing trend between 2007 and 2009 and 2019 (p = 0.019). Our findings report a particular concern of emerging contaminant medium chain chlorinated paraffin exposure to humans. Future observational studies with repeated measurements of chlorinated paraffins in general populations worldwide and large sample size are warranted. CI - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Xu, Shanshan AU - Xu S AD - Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, 7491, Norway. FAU - Hansen, Solrunn AU - Hansen S AD - Department of Health and Care Sciences, UiT the Arctic University of Norway, Tromso, 9037, Norway. FAU - Rautio, Arja AU - Rautio A AD - Arctic Health, Faculty of Medicine, University of Oulu, Oulu, Finland; Thule Institute, University of Arctic, University of Oulu, Oulu, Finland. FAU - Jarvelin, Marjo-Riitta AU - Jarvelin MR AD - Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Unit of Primary Care, Oulu University Hospital, Oulu, Finland; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, United Kingdom. FAU - Abass, Khaled AU - Abass K AD - Arctic Health, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Pesticides, Menoufia University, Menoufia, Egypt. FAU - Rysa, Jaana AU - Rysa J AD - Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland. FAU - Palaniswamy, Saranya AU - Palaniswamy S AD - Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. FAU - Huber, Sandra AU - Huber S AD - Department of Laboratory Medicine, University Hospital of North Norway, Sykehusveien 38, Tromso, NO-9038, Norway. FAU - Grimalt, Joan O AU - Grimalt JO AD - Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18, Barcelona, Catalonia, 08034, Spain. FAU - Dumas, Pierre AU - Dumas P AD - Institut Nacional de Sante Publique du Quebec (INSPQ), Quebec City, Canada. FAU - Odland, Jon Oyvind AU - Odland JO AD - Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, 7491, Norway; Department of General Hygiene I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119992, Russia. Electronic address: jon.o.odland@ntnu.no. LA - eng GR - MR/S019669/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210830 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Dibenzofurans, Polychlorinated) RN - 0 (Dioxins) RN - 0 (Environmental Pollutants) RN - 0 (Hydrocarbons, Chlorinated) RN - 0 (Pesticides) RN - 8002-74-2 (Paraffin) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Cohort Studies MH - Dibenzofurans, Polychlorinated MH - *Dioxins/analysis MH - Environmental Monitoring MH - *Environmental Pollutants MH - Female MH - Humans MH - *Hydrocarbons, Chlorinated/analysis MH - Paraffin MH - *Pesticides/analysis MH - *Polychlorinated Biphenyls/analysis MH - Pregnancy OTO - NOTNLM OT - Chlorinated paraffins OT - Dioxins OT - Northern Norway OT - Organochlorine pesticides OT - Polychlorinated biphenyls OT - Pooled sample EDAT- 2021/09/03 06:00 MHDA- 2022/01/08 06:00 CRDT- 2021/09/02 20:12 PHST- 2021/06/24 00:00 [received] PHST- 2021/08/25 00:00 [revised] PHST- 2021/08/25 00:00 [accepted] PHST- 2021/09/03 06:00 [pubmed] PHST- 2022/01/08 06:00 [medline] PHST- 2021/09/02 20:12 [entrez] AID - S0013-9351(21)01275-5 [pii] AID - 10.1016/j.envres.2021.111980 [doi] PST - ppublish SO - Environ Res. 2022 Mar;204(Pt A):111980. doi: 10.1016/j.envres.2021.111980. Epub 2021 Aug 30.