PMID- 34474251
OWN - NLM
STAT- MEDLINE
DCOM- 20211102
LR  - 20211102
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 150
DP  - 2021 Nov
TI  - The medium to long-term effects of two-duct ligation for excessive drooling in 
      neurodisabilities, a cross-sectional study.
PG  - 110894
LID - S0165-5876(21)00287-1 [pii]
LID - 10.1016/j.ijporl.2021.110894 [doi]
AB  - OBJECTIVES: This study aims to evaluate the medium to long-term (1-12 years) 
      effectiveness of two-duct ligation (2-DL) in patients with nonprogressive 
      neurodisabilities. METHODS: Main outcomes included a Visual Analogue Scale (VAS), 
      Drooling Severity (DS) and Drooling Frequency (DF), collected at baseline, 32 
      weeks postintervention and 1-12 years postintervention. Secondary outcomes were 
      adverse events (AEs), and satisfaction. RESULTS: Forty-two patients were analyzed 
      (mean age 17 years, mean baseline VAS 82). VAS decreased significantly from 
      baseline to long-term (n = 30. Mean difference -36.5, CI -47.0 to -26.0, 
      p </= 0.001; -26.1, CI -36.2 to -15.9, p </= 0.001). However, long-term VAS 
      significantly increased compared to VAS at 32 weeks (+10.4, CI 1.0-19.8, 
      p = 0.031). Out of 42 patients, 64% would recommend 2-DL to peers. CONCLUSION: 
      There is a significant subjective 2-DL effect on drooling severity in the medium 
      to long-term as reported by patients and caregivers, but there is also a certain 
      degree of recurrence in this time span, and 33% of the patients required 
      subsequent treatment. However, the majority of patients and/or caregivers would 
      recommend 2-DL to peers.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Bekkers, Stijn
AU  - Bekkers S
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University 
      Medical Center, Nijmegen, the Netherlands. Electronic address: 
      stijn.bekkers@radboudumc.nl.
FAU - de Bock, Sanne
AU  - de Bock S
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University 
      Medical Center, Nijmegen, the Netherlands.
FAU - van Hulst, Karen
AU  - van Hulst K
AD  - Department of Rehabilitation, Radboud University Medical Center, Donders 
      Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
FAU - Kok, Saskia E
AU  - Kok SE
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University 
      Medical Center, Nijmegen, the Netherlands.
FAU - Scheffer, Arthur R T
AU  - Scheffer ART
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University 
      Medical Center, Nijmegen, the Netherlands.
FAU - van den Hoogen, Frank J A
AU  - van den Hoogen FJA
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University 
      Medical Center, Nijmegen, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20210827
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
SB  - IM
MH  - Adolescent
MH  - *Cerebral Palsy
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Neoplasm Recurrence, Local
MH  - *Sialorrhea/etiology/surgery
MH  - Submandibular Gland
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cerebral palsy
OT  - Drooling
OT  - Duct-ligation
OT  - Neurodevelopmental disorder
EDAT- 2021/09/03 06:00
MHDA- 2021/11/03 06:00
CRDT- 2021/09/02 20:19
PHST- 2021/03/09 00:00 [received]
PHST- 2021/05/31 00:00 [revised]
PHST- 2021/08/20 00:00 [accepted]
PHST- 2021/09/03 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/09/02 20:19 [entrez]
AID - S0165-5876(21)00287-1 [pii]
AID - 10.1016/j.ijporl.2021.110894 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2021 Nov;150:110894. doi: 
      10.1016/j.ijporl.2021.110894. Epub 2021 Aug 27.