PMID- 34475005
OWN - NLM
STAT- MEDLINE
DCOM- 20220620
LR  - 20221130
IS  - 1995-9133 (Electronic)
IS  - 1684-1182 (Print)
IS  - 1684-1182 (Linking)
VI  - 55
IP  - 3
DP  - 2022 Jun
TI  - Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients.
PG  - 421-427
LID - S1684-1182(21)00183-3 [pii]
LID - 10.1016/j.jmii.2021.08.009 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) plays an important role in immune 
      responses to infections, especially in the development of acquired immunity. 
      Given the high degree of polymorphisms that HLA molecules present, some will be 
      more or less effective in controlling SARS-CoV-2 infection. We wanted to analyze 
      whether certain polymorphisms may be involved in the protection or susceptibility 
      to COVID-19. METHODS: We studied the polymorphisms in HLA class I (HLA-A, -B and 
      -C) and II (HLA-DRB1 and HLA-DQB1) molecules in 450 patients who required 
      hospitalization for COVID-19, creating one of the largest HLA-typed patient 
      cohort to date. RESULTS: Our results show that there is no relationship between 
      HLA polymorphisms or haplotypes and susceptibility or protection to COVID-19. 
      CONCLUSION: Our results may contribute to resolve the contradictory data on the 
      role of HLA polymorphisms in COVID-19 infection.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Gutierrez-Bautista, Juan Francisco
AU  - Gutierrez-Bautista JF
AD  - Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de Las 
      Nieves, Granada, Spain; Programa de Doctorado en Biomedicina, University of 
      Granada, Spain. Electronic address: juanfrety@gmail.com.
FAU - Rodriguez-Nicolas, Antonio
AU  - Rodriguez-Nicolas A
AD  - Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de Las 
      Nieves, Granada, Spain. Electronic address: antoniorn87@gmail.com.
FAU - Rosales-Castillo, Antonio
AU  - Rosales-Castillo A
AD  - Servicio de Medicina Interna, Hospital Universitario Virgen de Las Nieves, 
      Granada, Spain. Electronic address: 
      antonio.rosales.castillo.sspa@juntadeandalucia.es.
FAU - Lopez-Ruz, Miguel Angel
AU  - Lopez-Ruz MA
AD  - Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen de Las 
      Nieves, Granada, Spain; Instituto de Investigacion Biosanitaria de Granada 
      (ibs.GRANADA), Granada, Spain; Departamento de Medicina, University of Granada, 
      Granada, Spain. Electronic address: malruz@ugr.es.
FAU - Martin-Casares, Antonia Maria
AU  - Martin-Casares AM
AD  - Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de Las 
      Nieves, Granada, Spain. Electronic address: tonimartin-63@hotmail.com.
FAU - Fernandez-Rubiales, Alonso
AU  - Fernandez-Rubiales A
AD  - Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de Las 
      Nieves, Granada, Spain. Electronic address: Alonsofdezru@gmail.com.
FAU - Anderson, Per
AU  - Anderson P
AD  - Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de Las 
      Nieves, Granada, Spain; Instituto de Investigacion Biosanitaria de Granada 
      (ibs.GRANADA), Granada, Spain. Electronic address: per.anderson@ibsgranada.es.
FAU - Garrido, Federico
AU  - Garrido F
AD  - Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de Las 
      Nieves, Granada, Spain; Instituto de Investigacion Biosanitaria de Granada 
      (ibs.GRANADA), Granada, Spain; Departamento Bioquimica, Biologia Molecular e 
      Inmunologia III, University of Granada, Granada, Spain. Electronic address: 
      federico.garrido.sspa@juntadeandalucia.es.
FAU - Ruiz-Cabello, Francisco
AU  - Ruiz-Cabello F
AD  - Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de Las 
      Nieves, Granada, Spain; Instituto de Investigacion Biosanitaria de Granada 
      (ibs.GRANADA), Granada, Spain; Departamento Bioquimica, Biologia Molecular e 
      Inmunologia III, University of Granada, Granada, Spain. Electronic address: 
      fruizc@ugr.es.
FAU - Lopez-Nevot, Miguel Angel
AU  - Lopez-Nevot MA
AD  - Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de Las 
      Nieves, Granada, Spain; Instituto de Investigacion Biosanitaria de Granada 
      (ibs.GRANADA), Granada, Spain; Departamento Bioquimica, Biologia Molecular e 
      Inmunologia III, University of Granada, Granada, Spain. Electronic address: 
      manevot@ugr.es.
LA  - eng
PT  - Journal Article
DEP - 20210825
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - *COVID-19/genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-A Antigens/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/genetics
MH  - Humans
MH  - SARS-CoV-2
PMC - PMC8384756
OTO - NOTNLM
OT  - COVID-19
OT  - HLA polymorphisms
OT  - SARS-CoV-2
COIS- Declaration of competing interest The authors declare that the research was 
      conducted in the absence of any commercial or financial relationships that could 
      be construed as a potential conflict of interest.
EDAT- 2021/09/04 06:00
MHDA- 2022/06/22 06:00
PMCR- 2021/08/25
CRDT- 2021/09/03 05:44
PHST- 2021/02/08 00:00 [received]
PHST- 2021/07/29 00:00 [revised]
PHST- 2021/08/05 00:00 [accepted]
PHST- 2021/09/04 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2021/09/03 05:44 [entrez]
PHST- 2021/08/25 00:00 [pmc-release]
AID - S1684-1182(21)00183-3 [pii]
AID - 10.1016/j.jmii.2021.08.009 [doi]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2022 Jun;55(3):421-427. doi: 
      10.1016/j.jmii.2021.08.009. Epub 2021 Aug 25.